Blood Cells (eBook)

A Practical Guide

Barbara J. Bain, Mike Leach (Autoren)

eBook Download: EPUB

2025 | 7. Auflage
2004 Seiten
Wiley (Verlag)
9781394332069 (ISBN)

Infos

A comprehensive guide to blood cell morphology and interpretation, fully updated throughout

Understanding blood cell morphology and interpreting blood counts accurately is essential for both haematologists and biomedical scientists. This meticulously updated and comprehensive seventh edition of Blood Cells: A Practical Guide combines expert guidance with high-quality imaging. This edition introduces new clinical images to enhance the contextual understanding of haematological findings, alongside the latest WHO and International Consensus classifications of haematological neoplasms.

Blood Cells: A Practical Guide bridges the gap between laboratory science and clinical application, covering essential techniques such as specimen collection, blood film preparation and staining. The authors also discuss the principles of manual and automated blood counts, as well as abnormalities in blood counts and films within a clinical context. With up-to-date advice on additional tests to aid diagnosis, this new edition reinforces the importance of microscopy whilst addressing the evolving demands of laboratory and clinical haematology.

Designed as both a reference for practising haematologists and a bench manual for trainees, Blood Cells: A Practical Guide:

• Features new high-quality clinical and morphological images to enhance blood cell identification and interpretation
• Highlights potential pitfalls and spurious results in haematological analysis to improve diagnostic accuracy
• Offers a self-assessment component with multiple choice questions (MCQs) and extended matching questions (EMQs) available online
• Is written by leading experts with decades of experience in diagnostic haematology and blood cell morphology

Blood Cells: A Practical Guide remains an indispensable resource for those dedicated to the study and practice of haematology, such as haematologists, clinical scientists, and biomedical scientists at all levels. It also serves as a valuable reference for diagnostic haematology courses and laboratory training programmes in medical and biomedical science degrees.

Barbara J. Bain is a renowned haematologist with over 50 years of experience in clinical and laboratory haematology. She is Professor Emerita of Diagnostic Haematology at Imperial College London and Honorary Consultant Haematologist at St Mary's Hospital, London. She has contributed to the WHO Classification of Tumours of Haemopoietic and Lymphoid Tissues and has authored numerous influential publications in the field.

Mike Leach is a Consultant Haematologist at the Beatson West of Scotland Cancer Centre and Gartnavel General Hospital. With a strong focus on diagnostic haematopathology, he has extensive expertise in blood film morphology and haematological disease. As an Honorary Senior Lecturer, he is actively involved in the education and training of future haematologists and laboratory scientists.

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List of abbreviations

aCML

atypical chronic myeloid leukaemia

ACTH

adrenocorticotropic hormone

AD

autosomal dominant

AE1

anion exchanger 1

AIDS

acquired immune deficiency syndrome

AIHA

autoimmune haemolytic anaemia

ALL

acute lymphoblastic leukaemia

AML

acute myeloid leukaemia

ANAE

α‐naphthyl acetate esterase

ANBE

α‐naphthyl butyrate esterase

APAAP

alkaline phosphatase anti‐alkaline phosphatase (technique)

AR

autosomal recessive

ATLL

adult T‐cell leukaemia/lymphoma

ATP

adenosine triphosphate

BCSH

British Committee for Standards in Haematology

B‐PLL

B‐lineage prolymphocytic leukaemia

CAE

chloroacetate esterase

CAR‐T

chimaeric antigen receptor T‐cell (therapy)

CBC

complete blood count

CD

cluster of differentiation

CDA

congenital dyserythropoietic anaemia

CDC

Centers for Disease Control

CEL

chronic eosinophilic leukaemia

CGH

comparative genomic hybridisation

CHCM

cellular haemoglobin concentration mean

CLL

chronic lymphocytic leukaemia

CLL/PL

CLL, mixed cell type

CLSI

Clinical & Laboratory Standards Institute

CML

chronic myeloid leukaemia

CMML

chronic myelomonocytic leukaemia

CMV

cytomegalovirus

CPD

cell population data

CRP

C‐reactive protein

CV

coefficient of variation

2,3‐DPG

2,3‐diphosphoglycerate

DDAVP

1‐deamino‐8‐D‐arginine vasopressin

DIC

disseminated intravascular coagulation

DNA

deoxyribonucleic acid

EBV

Epstein–Barr virus

EDTA

ethylenediaminetetra‐acetic acid

EMA

eosin‐5‐maleimide

ESR

erythrocyte sedimentation rate

ET

essential thrombocythaemia

FAB

French–American–British (classification)

FBC

full blood count

FDA

Food and Drug Administration

FISH

fluorescence in situ hybridisation

FITC

fluorescein isothiocyanate

FLAER

fluorescein‐labelled proaerolysin

FRC

red cell fragments

G6PD

glucose‐6‐phosphate dehydrogenase

G‐CSF

granulocyte colony‐stimulating factor

GM‐CSF

granulocyte‐macrophage colony‐stimulating factor

GPI

glycosylphosphatidylinositol

HAART

highly active antiretroviral therapy

Hb

haemoglobin concentration

Hct

haematocrit

HDW

haemoglobin distribution width

HELLP

haemolysis, elevated liver enzymes and low platelet count (syndrome)

HEMPAS

hereditary erythroid multinuclearity with positive acidified serum test

HES

hypereosinophilic syndrome

HHV6

human herpesvirus 6

HIV

human immunodeficiency virus

HLA

histocompatibility locus antigen

HPC

haemopoietic progenitor cells

HPFH

hereditary persistence of fetal haemoglobin

HPLC

high‐performance liquid chromatography

HTLV‐1

human T‐cell lymphotropic virus 1

ICC

International Consensus Classification

ICSH

International Council for Standardization on Haematology

ICUS

idiopathic cytopenia of undetermined significance

Ig

immunoglobulin

IL

interleukin

IRIDA

iron‐refractory iron deficiency anaemia

ITP

immune (autoimmune) thrombocytopenic purpura

JMML

juvenile myelomonocytic leukaemia

LCAT

lecithin‐cholesterol acyltransferase

LDH

lactate dehydrogenase

LE

lupus erythematosus

LUC

large unstained (peroxidase‐negative) cell

MCH

mean cell haemoglobin

MCHC

mean cell haemoglobin concentration

M‐CSF

macrophage colony‐stimulating factor

MCV

mean cell volume

MDS

myelodysplastic neoplasm/syndrome/s

MDS/MPN

myelodysplastic/myeloproliferative neoplasm

MDW

monocyte distribution width

MGG

May–Grünwald–Giemsa (stain)

MIRL

membrane inhibitor of reactive lysis

MLV

mean lymphocyte volume

MMV

mean monocyte volume

MNV

mean neutrophil volume

MPAL

mixed phenotype acute leukaemia

MPC

mean platelet component concentration

MPM

mean platelet mass

MPO

myeloperoxidase

MPV

mean platelet volume

MPXI

mean peroxidase index

MRV

mean reticulocyte volume

MSCV

mean sphered cell volume

NAP

neutrophil alkaline phosphatase

NASA

naphthol AS acetate esterase

NASDA

naphthol AS‐D acetate esterase

NDW

neutrophil distribution width

NK

natural killer (cell)

NRBC

nucleated red blood cell

PAS

periodic acid–Schiff (reaction)

PCDW

platelet component distribution width

PCH

paroxysmal cold haemoglobinuria

PCR

polymerase chain reaction

Pct/PCT

plateletcrit

PCV

packed cell volume

PDW

platelet distribution width

Peg‐rHuMGDF

polyethylene glycol recombination human megakaryocyte growth and development factor

PHA

phytohaemagglutinin

P‐LCR

platelet large cell ratio

PLL

prolymphocytic leukaemia

PMDW

platelet mass distribution width

PNH

paroxysmal nocturnal haemoglobinuria

POEMS

polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (syndrome)

PV

polycythaemia vera

RAEB

refractory anaemia with excess of blasts

RARS

refractory anaemia with ring sideroblasts

RBC

red blood cell count

RCMD

refractory cytopenia with multilineage dysplasia

RCUD

refractory cytopenia with unilineage dysplasia

RDW

red cell distribution width

RNA

ribonucleic acid

...

Produkt-Details

• Erscheint lt. Verlag: 18.7.2025
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Schlagworte: blood cell morphology • blood count interpretation • blood film analysis • diagnostic haematology • haematological diagnosis reference • haematological neoplasms • haematology bench manual • haematology guide • haematology reference • Haematopathology
• ISBN-13: 9781394332069 / 9781394332069