Cancer Metabolism

From Molecules to Medicine

Gautam Sethi, Arun Kumar Singh, Hitesh Chopra, Milad Ashrafizadeh, AMIR REZA AREF (Autoren)

Buch | Softcover

325 Seiten

2026
Academic Press Inc (Verlag)
9780443336690 (ISBN)

Infos

Cancer Metabolism: From Molecules to Medicine delivers groundbreaking insights and the latest research into the pivotal role of cancer metabolism in oncology and therapeutic strategies. This book underscores cancer metabolism as a foundational element of cancer biology, predating even the identification of oncogenes and tumor suppressors. It reveals how, unlike normal cells, cancerous cells modify their metabolic pathways to support malignancy, providing new avenues for therapeutic intervention. This book is divided into 16 chapters, delving into the core topics of cancer cell metabolism, metabolic disorders, and autophagy's role in tumor cell metabolism. These subjects illustrate the cellular fitness enhancement via metabolic reprogramming, offering tumors a selective edge through enhanced biosynthesis, altered bioenergetics, and redox balance. This book provides a thorough exploration of how these reprogrammed metabolic processes not only support cancer cell survival and proliferation but also present viable targets for innovative cancer treatments. “Cancer Metabolism: From Molecules to Medicine” serves as an essential resource for scientists and researchers seeking an in-depth understanding of the molecular mechanisms at play in cancer metabolism and its implications for therapy. Additionally, clinicians will find value in the comprehensive coverage of how these metabolic insights translate into novel treatment strategies, bridging the gap between basic research and clinical application. The book's focus on metabolic pathways as therapeutic targets offers practitioners new tools for combating cancer, making it a must-read for both the scientific and medical communities aiming to advance their knowledge and therapeutic capabilities in the dynamic field of cancer metabolism.

Autor

Dr. Gautam Sethi is a tenured Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism(s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted several publications in high impact factor peer reviewed journals and many international awards. He also serves as an editorial board member for over more than 15 international journals Arun Kumar Singh completed his Master of Pharmacy (M. Pharm) in Pharmaceutics from Galgotias University, Greater Noida, India. He is currently an Assistant Professor in the Department of Pharmacy at Vivekanand Global University, where he is actively engaged in teaching and research. His research interests encompass various emerging and interdisciplinary fields, including nano-formulation, blockchain technology, the Internet of Things (IoT), machine learning, cancer biology, artificial intelligence, big data analytics, and neuroscience. Demonstrating a strong commitment to academic excellence, Mr. Singh has made significant contributions to the scientific community. Dr. Hitesh Chopra, PhD currently at Saveetha School of Engineering is working in primarily area of interest includes nanoformulations, natural polymers, cancer, and wound healing and metabolic disorders. He has authored several papers in high-repute journals with total impact factor more than 1000 Dr Milad Ashrafizadeh is a researcher in Sabanci university, Turkey and obtained his degree in field of Veterinary Medicine in 2020. He is an invited scholar in University of Electronic Science & Technology of China. Currently, Milad is an Editorial Board in journal of nanostructure in chemistry (IF= 6.39) and is a review editor in Frontiers journals. He has published review and research articles in international and famous journals in world. Milad has also 4 book chapters. He has published articles in high quality journals including Nanotoday, Coordination Chemistry Reviews, Advanced Science, Carbohydrate Polymers, Journal of Controlled Release and Advances in Colloid and Interface Science, among others. His interests include nanomedicine, application of nanoparticles for drug and gene delivery, targeted cancer therapy, non-coding RNAs in cancer and development of biosensors. Dr. Amir Reza Aref is a scientist at the Belfer Center of Applied Cancer Science, within the Dana-Farber Cancer Institute at Harvard Medical School. He made the important discovery in that it is possible to culture primary tumors in a novel 3D microfluidic system, by digesting them with collagenase and capturing spheroids that are composed of a mixture of tumor and immune cells. In addition, he has demonstrated the ability to treat these tumor spheroids with small molecule inhibitors and measure cytokine responses by collecting conditioned media from the device. This innovative technology is a major advance upon traditional 2D cell line culture and even organoid systems, which require time to establish and lack the immune microenvironment. Furthermore, it enables tumor cytokine profiling in a way not previously possible. Prior to joining the Belfer, he was an Instructor and a research fellow in the Medical Oncology Division at Harvard Medical School, where he characterized Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit in lung tumorigenesis which was resulted to start a new clinical trial at DFCI under supervision of Dr. David Barbie in 2015. He has also completed his post-doctoral in the Biological Engineering Department at MIT between 2009 and 11.

Inhalt

1. An introduction to cancer metabolism
2. Cancer development and metabolic disorders: Potential Role of metabolic disorders in cancer progression.
3. The New Metabolic Therapy: A Key to a Revolutionary Approach to Cancer Treatment
4. The changing molecular nature of autophagy in cancer metabolism
5. Autophagy and tumor cell metabolism as potential treatment approaches
6. The role of autophagy in the control of cancer and its therapeutic applications at the present time
7. Cancer-associated fibroblasts and autophagy: biology and targeting
8. Mechanisms of signal transduction in solid tumor metabolic dysregulation
9. Cancer medication development based on autophagy and metabolic control
10. Involvement of mitophagy in metabolic reprogramming in tumors and cancer stem cells
11. Changes in Glycolysis and Lipid Metabolism as Molecular Properties of Cancer Cells
12. Cancer metabolism molecules and pathways elucidated and therapeutic implications
13. Molecular understanding of cancer metabolism: Metabolic interactions within tumor microenvironments, and therapeutic implications
14. Targeting cancer metabolism as a potential therapeutic strategy
15. Metabolic Pathways in Cancer: Phenotype, Signalling, and Potential Therapeutic Agents
16. Cancer Metabolism: Immune System Regulation and Metabolism Mechanisms in Cancer Development

Produkt-Details

• Erscheint lt. Verlag: 5.1.2026
• Verlagsort: San Diego
• Sprache: englisch
• Maße: 191 x 235 mm
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• ISBN-13: 9780443336690 / 9780443336690
• Zustand: Neuware