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Challenges and Elucidation of Drug Solubility

Pragya Baghel, Monika Bhairam, Sanjib Bahadur (Herausgeber)

Buch | Hardcover

249 Seiten

2025 | Unabridged edition
Cambridge Scholars Publishing (Verlag)
978-1-0364-4780-9 (ISBN)

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Solubility is a pivotal parameter in the pharmaceutical industry, as it directly influences the bioavailability and efficacy of drug molecules. Approximately 40% of new drug candidates exhibit poor aqueous solubility, which can result in diminished therapeutic effects and the need for higher dosages. To address this challenge, researchers have explored various techniques to enhance the solubility of poorly soluble drugs.This comprehensive guide delves into the underlying causes of poor solubility, such as the increasing hydrophobicity and low water-solubility of lead compounds and marketed drugs. The book then systematically explores a range of solubilization approaches, including salt formation, particle size reduction, solid dispersions, and the use of drug nanoparticles. Each method is thoroughly examined, with detailed discussions on the theoretical basis, practical implementation, and the advantages and limitations of each technique.By delving into the fundamental principles and the latest advancements in solubility enhancement, this book offers a valuable resource for pharmaceutical scientists, researchers, and industry professionals seeking to overcome the solubility hurdle and drive the development of more effective and patient-centric drug products.

Dr Pragya Baghel was awarded her PhD in 2022 from Chhattisgarh Swami Vivekananda Technical University, India. Her specific area of research is in pharmaceutical sciences, nanoformulations, enhancing solubility and bioavailability of poorly aqueous soluble drugs. She is a life member of many National and International organizations, like the Association of Pharmaceutical Teachers of India.Dr Monika Bhairam was awarded her PhD from Chhattisgarh Swami Vivekananda Technical University, India. She secured a gold medal in MPharm. Her specific area of research is pharmaceutical sciences. Dr Sanjib Bahadur completed his PhD from Chhattisgarh Swami Vivekananda Technical University, India. His research interests are formulation and development, NDDS and CRDDS and has more than 16 years of Teaching and Research Experience. Dr Shekhar Verma has a doctorate degree from University Teaching Department, Guru Ghasidas Central University, BilaspurIndia. Presently he is working as Professor. He is a Task Force Member of the planning commission of Chhattisgarh State, India andcultural coordinator for the Association of Indian Universities (AIU), New Delhi.

Erscheinungsdatum	03.06.2025
Verlagsort	Newcastle upon Tyne
Sprache	englisch
Maße	148 x 212 mm
Themenwelt	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Technik
ISBN-10	1-0364-4780-4 / 1036447804
ISBN-13	978-1-0364-4780-9 / 9781036447809
Zustand	Neuware