LIVER CANCER AND PHYTOMEDICINE (eBook)

Chemoprevention, Chemo Sensitization and Chemotherapy Strategies

Lekshmi R Nath, Gautam Sethi, B S Vinod (Herausgeber)

eBook Download: EPUB

2025
648 Seiten
World Scientific Publishing Company (Verlag)
978-981-12-9333-7 (ISBN)

Infos

Liver Cancer and Phytomedicine systematically explores the potential of phytomedicines across three fundamental aspects of cancer management: prevention, sensitization, and therapy. This comprehensive book provides an extensive overview of the potential of important phytomedicines in managing liver cancer, encompassing areas such as prevention, sensitization therapy, modulation of gut microbiota, immunotherapy, and the emergence of phytonanomedicine. It serves as an invaluable resource for researchers and students in life sciences, biotechnology, and pharmaceutical sciences, offering insights into plant-derived therapeutics for liver cancer. The book explores the impact of phytomedicines on various facets of liver cancer biology, ranging from the tumor microenvironment to drug resistance pathways. Additionally, it discusses various clinical challenges and proposes strategies for transitioning to phytonanomedicine, providing valuable insights for researchers and clinicians engaged in developing liver cancer therapeutics.

Contents:

• Phytochemicals Targeting Tumor Microenvironment in Hepatocellular Carcinoma (Sruti C and Chithra JS)
• Phytochemicals in Liver Cancer Prevention (Shelmi Antony, Nisha N C and Jayesh Antony)
• Role of Dietary Supplementation in the Management of Liver Disease (KL Ajee and KT Moly)
• Therapeutic Potential of Phytochemicals: Preclinical Insights in Hepatocellular Carcinoma (Anisha Vadakkepatt and Rafia Islam)
• Phytochemicals to Target Sorafenib Resistance Pathways in Liver Cancer (Shreyas Hulusemane Karunakara, Varsha Dilip Shiragannavar, Nirmala Gollarahalli Sannappagowda, Shama Prasada Kabekkodu, Divya Prasanna Kumar and Prasanna Kumar Santhekadur)
• Phytochemicals as Chemosensitizers in the Management of Hepatocellular Carcinoma (Silpa Prabha, Anju Jose, Aleena Mariya Davis and Kanjoormana Aryan Manu)
• Phytomedicine in the Battle Against Liver Cancer: The Impact of Phytochemical mTOR Inhibition (Srishti Bhargav, Sumitra Patel, Shweta Shrivastava, Rajan Swami, and Manish Kumar Jeengar)
• Therapeutic Role of Phytochemicals in Angiogenesis and Metastasis of Liver Cancer (Dr. Shweta Kumar)
• Cucurbitacin B: A Potential Therapeutic Agent Against Liver Cancer (A Amrutha Nisthul, US Aiswarya, MA Faisal and VB Smitha)
• Critical Role of Phytochemicals in Gut-Microbiota-Associated Liver Cancer (Sancharan Acharya and Chinnasamy Thirunavukkarasu)
• Emerging Role of Plant-Derived Products in Immunotherapy: Plausible Exposition for HCC Treatment (Ayana R Kumar, SA Ajay, K Anusha, Bhagyalakshmi Nair, Aswathy R Devan, Gautam Sethi, and Lekshmi R Nath)
• Overview of the Clinical Significance of Phytomolecules in Liver Cancer (PR Roshni, Bilha Baby and Shine Sadasivan)
• Phytochemicals in Liver Cancer-Translational Limitations and Strategies (Akhila S and Remya K)
• Clinical Trials Using Phytochemicals in Liver Cancer Treatment: How Far is the Research? (Chameli Ratan and Uday Kumar R)
• The Emerging Role of Phytochemicals in Nanotechnology for Targeting Liver Cancer (Deiviga Murugan, Sweata Hanson, Jinsha P V, Raja Biswas, Bipin G Nair, Sankarprasad Bhuniya, and Nandita Mishra)

Readership: Post graduate and PhD students in the field of Ayurveda, Pharmaceutical Science, Naturopathy. Researchers and practitioners in the field of Oncology, Phytotherapy and Cancer Drug development.

Dr Lekshmi R Nath is an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Trivandrum, Kerala, an autonomous Research Institution under DBT, Govt: of India. Her Ph.D. findings on Hepatocellular carcinoma recently received four international patents US, Canada, Japan & South Korea (WO 2017208254 A1, 'Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma'). The USFDA has recently granted an Orphan drug designation to the small molecule chemotherapeutic Uttroside–B against hepatocellular carcinoma. MOU signed by RGCB with Oklahoma Medical Research Foundation, USA, for the clinical translation of Uttroside B in liver cancer patients and technology transfer carried out with a multi-national company, Q Biomed. She has more than 45 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemosensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for various infectious diseases, their mechanism of action and validation through pre-clinical models.Dr Gautam Sethi is an Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism (s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted in more than four hundred scientific publications in high impact factor peer reviewed journals and several international awards. He also serves as an editorial board member for several international journals including Antioxidants & Redox Signaling, Cancer Letters, Pharmacological Research, Scientific Reports, International Journal of Cancer, BMC Cancer, Cells, Frontiers in Pharmacology, International Journal of Biological Sciences, International Journal of Oncology, International Journal of Cancer, Journal of Functional Foods, PLOS One, and ad-hoc reviewer for several other prestigious international journals. He is currently also ranked among the world's most highly cited scientists according to the list of Highly Cited ResearchersTM released in both 2020 and 2021 by Clarivate.Dr Vinod B S is an Assistant professor at the Department of Biochemistry, Sree Narayana College, Kollam, Affiliated to University of Kerala, India. His research areas include chemosensitization, elucidation of chemoresistance pathways and bioprospecting. He has a PhD in Biochemistry from Rajiv Gandhi Centre for Biotechnology, India. He has published 10 peer-reviewed journal articles in prestigious journals and is a reviewer for several international journals. At the college level he is the coordinator of Star College Scheme for Strengthening of Science Education and Training at Undergraduate Level launched by the Department of Biotechnology, Govt of India. He is an active member in several committees and academic bodies both at the college and at the University Level.

Produkt-Details

• Erscheint lt. Verlag: 27.2.2025
• Verlagsort: Singapore
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie
• ISBN-10: 981-12-9333-3 / 9811293333
• ISBN-13: 978-981-12-9333-7 / 9789811293337