Platelets

Alan D. Michelson (Autor)

Buch | Hardcover

1376 Seiten

2006 | 2nd edition
Academic Press Inc (Verlag)
978-0-12-369367-9 (ISBN)

Infos

Provides knowledge about platelets and covers the field of platelet biology, pathophysiology, and clinical medicine. This book also features chapters on platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias.

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Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

Autor

Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children’s Hospital, Brigham and Women’s Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews – nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.

Inhalt

Part One: Platelet Biology
1. The Evolution of Mammalian Platelets
2. Megakaryocyte Development and Platelet Formation
3. Platelet Structure
4. The Platelet Cytoskeleton
5. Platelet Genomics and Proteomics
6. Platelet Receptors
7. The Glycoprotein Ib-IX-V Complex
8. Integrin αIIbβ3
9. Thrombin Receptors
10. The Platelet P2 Receptors
11. PECAM-1
12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium
13. Inhibition of Platelet Function by the Endothelium
14. Platelet Polymorphisms
15. Platelet Secretion
16. Signal Transduction During the Platelet Plug Formation
17. Outside-in Signaling By Integrin αIIbβ3
18. Platelet Thrombus Formation in Flowing Blood
19. Interactions Between Platelets and the Coagulation System
20. Platelet-Derived Microparticles
21. The Role of Platelets in Fibrinolysis
22. Platelet Function in the Newborn

Part Two: Tests of Platelet Function
23. Clinical Tests of Platelet Function
24. Platelet Counting
25. The Bleeding Time
26. Platelet Aggregation
27. The VerifyNow System
28. Platelet Function Analyzer (PFA)-100
29. Impact Cone and Plate(let) Analyzer
30. Flow Cytometry
31. Thromboxane Generation
32. Perfusion Chambers
33. Animal Models
34. Real Time In Vivo Imaging of Platelets During Thrombus Formation

Part Three: The Role of Platelets in Disease
35. Atherothrombosis and Coronary Artery Disease
36. Central Nervous System Ischemia
37. Peripheral Vascular Disease
38. Diabetes Mellitus
39. Inflammation
40. Antimicrobial Host Defense
41. Angiogenesis
42. Tumor Growth and Metastasis
43. Alzheimer’s Disease
44. Psychiatric Disorders

Part Four: Disorders of Platelet Number and Function
45. The Clinical Approach to Disorders of Platelet Number and Function
46. Immune Thrombocytopenic Purpura
47. HIV-1-related Thrombocytopenia
48. Heparin-induced Thrombocytopenia
49. Drug-induced Thrombocytopenia
50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome
51. Thrombocytopenia in Pregnancy
52. Thrombocytopenia in the Newborn
53. Alloimmune Thrombocytopenia
54. Inherited Thrombocytopenias
55. Pseudothrombocytopenia
56. Thrombocytosis and Essential Thrombocythemia
57. Inherited Disorders of Platelet Function
58. Acquired Disorders of Platelet Function
59. Cardiopulmonary Bypass

Part Five: Pharmacology: Antiplatelet Therapy
60. Aspirin
61. ADP Receptor Antagonists
62. αIIbβ3 (GPIIb-IIIa) Antagonists
63. Dipyridamole
64. Cilostazol
65. Experimental Antiplatelet Therapy

Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function
66. Platelet Growth Factors
67. Desmopressin (DDAVP)
68. Factor VIIa

Part Seven: Platelet Transfusion Medicine
69. Platelet Storage and Transfusion
70. Platelet Substitutes and Novel Methods of Platelet Preservation

Part Eight: Gene Therapy for Platelet Disorders
71. Gene Therapy for Platelet Disorders

Produkt-Details

• Erscheint lt. Verlag: 13.11.2006
• Verlagsort: San Diego
• Sprache: englisch
• Maße: 216 x 279 mm
• Gewicht: 2960 g
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• ISBN-10: 0-12-369367-5 / 0123693675
• ISBN-13: 978-0-12-369367-9 / 9780123693679
• Zustand: Neuware