Transdermal Fentanyl

A New Approach to Prolonged Pain Control

Klaus A. Lehmann, Detlev Zech (Herausgeber)

Buch | Softcover

XIII, 203 Seiten

1991
Springer Berlin (Verlag)
978-3-540-54440-1 (ISBN)

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That pain is a serious clinical problem, which requiresconsiderable effortsby physicians and the nursing staff,has been stressed in numerous publications. Transdermalapplication is well known for a variety of drugs, includingcardiovascular drugs, antiemetics and hormones. Some yearsago, first experience was also made with transdermallyadministered opiates from which the transdermal therapeuticsystem (TTS) fentanyl has now been approved by the AmericanFood and Drug Administration.The book presents the results of the first internationalworkshop "Transdermal Fentanyl", held September 27 -28,1990 in Cologne, FRG. This workshop was intended tofacilitate a critical evaluation of theoretical and clinicalstudies with the new, non-invasive fentanyl application andto provide an opportunity for an exchange of ideas about itsvalue for pain management, anaesthesiology and futureinvestigations in this field. Topics covered by the book arephysiology of transdermal permeation, experience with othertransdermal systems, the present state of acute and chronicpain management and experimental and clinical studies withtransdermal fentanyl, with special concern to analgesicefficacy and side effects.Readers will easily find out that the experts appreciatedtransdermal analgesia but also warned against an uncriticaloptimism. TTS fentanyl can be a valuable tool in theclinicians' armentarium against pain. It should be kept inmind, however, that it represents a new administration mode,not a new drug, and that the sustained, non-invasiveapplication requires well reflected diagnosis and goodgeneral standards of pain management.

I Transdermal Therapeutic Systems - An Introduction.- Transdermal Permeation: Physiological and Physicochemical Aspects.- Transdermal Therapeutic Systems in Clinical Use: Development and Applications.- II Current Aspects of Pain Management.- Postoperative Pain.- Cancer Pain.- Pain Management and Quality of Life in Cancer Patients.- Opioid Analgesia for Chronic, Nonmalignant Pain.- III Noninvasive Fentanyl Application.- Pharmacokinetics of Fentanyl.- Premedication and Pain Management with Oral Transmucosal Fentanyl.- Transdermal Fentanyl: an Overview of Pharmacokinetics, Efficacy and Safety.- IV Postoperative Pain Management with TTS Fentanyl.- Pharmacokinetics and Pharmacodynamics.- Clinical Experience.- Respiratory Safety.- TTS Fentanyl in Combination with Patient-Controlled Analgesia.- V Cancer Pain Management with TTS Fentanyl.- Clinical Experience.- VI Other Transdermal Therapeutic Systems for Anesthesia and Pain Management.- Local Anesthetics: Eutectic Mixture of Local Anesthetics.- Scopolamine.

Erscheint lt. Verlag	31.10.1991
Zusatzinfo	XIII, 203 p. 14 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	360 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Anästhesie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Schmerztherapie
Schlagworte	acute and chronic • Analgesie • fentanyl Non-invasive administration • Opiate • Opiate analgesics • Opioid • Physiology • Schmerzbekämpfung • transdermal Pain management
ISBN-10	3-540-54440-2 / 3540544402
ISBN-13	978-3-540-54440-1 / 9783540544401
Zustand	Neuware