Neutron Capture Therapy
Springer International Publishing (Verlag)
9783031825903 (ISBN)
This book, now in a revised and updated second edition, provides a comprehensive summary of recent progress in boron neutron capture therapy (BNCT). BNCT is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and to release instantaneously two heavy particles with a path length of one cell diameter or less. This in principle allows for tumor cell-selective high-LET particle radiotherapy. In the past BNCT depended solely on fission reactor-based irradiation facilities, but the appearance of accelerator-based neutron sources placed in hospitals has opened a new chapter for BNCT.
This edition covers all the important aspects of BNCT, including neutron sources, boron chemistry, drugs for BNCT, boron analysis and imaging, dosimetry, and radiation biology. The use of BNCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. BNCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in a language that will be readily understood by all participating disciplines.
Prof. Dr. Wolfgang Sauerwein, MD, completed his medical studies in Limoges, France, and Essen, Germany. He is a board-certified radiologist and radiation oncologist and a retired professor from the Medical Faculty of the University Duisburg-Essen. Dr. Sauerwein is currently affiliated with MedAustron as a radiation oncologist and serves as a visiting professor at the Neutron Therapy Research Center of Okayama University. He is the editor-in-chief of Particles, the newsletter for the Particle Therapy Co-operative Group (PTCOG). His research has a primary focus on particle-based cancer therapies, including protons, neutrons, carbon ions, and Boron Neutron Capture Therapy (BNCT). From 1997 to 2003, he led the EORTC BNCT Group (European Organization for Research and Treatment of Cancer) and served as president of the International Society for Neutron Capture Therapy (ISNCT) from 2000 to 2002. Currently, he presides over the German BNCT Society (DGBNCT) and has been a founding member and co-chair of the PTCOG BNCT Subcommittee until 2023.
In 2021, Dr. Sauerwein founded BNCT Global GmbH to advance BNCT as a treatment modality. His clinical expertise also extends to radiation therapy for ocular tumors, applying both brachytherapy and advanced external beam radiation techniques using photons, electrons, and protons. A key focus of his practice is providing optimal, individualized particle beam therapy through international collaborations, ensuring efficient use of high-cost particle therapy facilities. Dr. Sauerwein's significant contributions have been recognized with several honors, including the Hatanaka Award from ISNCT in 2006 and Japan's "Order of the Rising Sun, Gold Rays with Neck Ribbon" ( ) in 2020, awarded by the Imperial House of Japan.
Prof. Dr. med. Andrea Wittig completed her medical studies in Essen (Germany). She is Head of the Department of Radiotherapy and Radiation Oncology at the University Hospital Würzburg and Professor of the Julius-Maximilians-Universität Würzburg (Germany). She serves as Member of the Board of Directors of the Comprehensive Cancer Center MainFranken, National Center for Tumor Disease.
As PhD student, she participated in the BNCT trials in Brookhaven and was later clinical investigator for the EORTC trials at the HFR High Flux Research Reactor of the European Commission in Petten. She has a broad experience in hadron therapy, including charged particles, as well as neutrons. Her research focus is on biologically individualized, high precision radiotherapy, which involves the investigation of the radiobiological and molecular basis of radiation oncology, as well as molecular targeting and translation of such basic approaches to in vivo and in-clinical studies. She is laureate of the Hermann-Holthusen Prize of the German Society for Radiation Oncology (2012) and of the Langendorff Prize of the German Society for Medical Physics and Hanns-Langendorff Foundation (2013).
Dr. Raymond Moss graduated and specialised (Ph.D. 1975) in Applied mathematics from the Universities of Hull, Sheffield and Nottingham (UK). He started work soon after in the nuclear field at the UK Atomic Energy Authority, followed by a brief spell in the petro-chemical industry, and since 1983 returned to nuclear research at the High Flux Reactor (HFR) of the Joint Research Centre of the European Commission at Petten in The Netherlands, where he project managed various research activities into the nuclear applications of neutrons. From 1988 to 2008, he was project manager of research activities into BNCT, leading ultimately to the start of the first clinical trials of BNCT in Europe, under the medical supervision of Prof. Dr. Med. Wolfgang Sauerwein. During this period, he was an active member of the Project Management Group of the European Collaboration on BNCT, the Project Coordination Committee on
1. Principles of Neutron Capture Therapy.- 2. History of Boron Neutron Capture Therapy.- 3. Fission reactor-based neutron irradiation facilities for BNCT.- 4. Neutron sources: accelerators (principles).- 5. Compact Neutron Generator for BNCT.- 6. Cyclotron-based neutron source, Sumitomo BNCT system, NeuCure .- 7. The accelerator-based BNCT system at the National Cancer Center Hospital (NCCH), Tokyo, Japan..- 8. iBNCT, a linac-based neutron source for boron neutron capture therapy, developed by the Tsukuba group.- 9. Dedicated solutions: Neutron Therapeutics .- 10. Dedicated solutions: DC tandem accelerator.- 11. Project of Proton Linac based BNCT system (A-BNCT) in Korea.- 12. A new neutron irradiation system Fukushima SiC.- 13. Neutron capture enhanced fast neutron therapy.- 14. Boron chemistry.- 15. Basic Information on Drug Development and Specific Requirements in the Case of BNCT.- 16. Basics of pharmacokinetics and pharmacodynamics.- 17. Drugs for BNCT: BSH and BPA.- 18. A commercially available BNCT Drug: Steboronine® from Stella Pharma.- 19. Boron Compounds: New Candidates for Boron Carriers in BNCT.- 20. Boron Analysis and Boron Imaging in BNCT.- 21. Proteomic Investigations for BNCT.- 22. Boron Imaging macroscopic: PET.- 23. Boron Imaging: Localized quantitative detection and imaging of Boron by Magnetic Resonance.- 24. In vivo dose distribution imaging.- 25. Physical Dosimetry and Spectral Characterization of Neutron Sources for Neutron Capture Therapy.- 26. The Clinical Commissioning of Beams for Neutron Capture Therapy.- 27. Commissioning of an accelerator-based BNCT facility for clinical purposes.- 28. Treatment Planning.- 29. Prescribing and reporting in BNCT.- 30. Boron Neutron Capture Therapy (BNCT) Radiobiology.- 31. The Tolerance of BNCT.- 32. BNCT of oral cavity melanoma in dogs.- 33. Latest research on radiobiology studies for the application of BNCT to thyroid cancer.- 34. Clinical trial design and strategies for the implementation of BNCT into clinical practice.- 35. External Beam BNCT for Glioblastoma Multiforme .- 36. BNCT, a Useful Modality to Treat Recurrent Malignant Gliomas.- 37. Boron neutron capture therapy for high-grade meningiomas.- 38. Malignant Melanoma.- 39. Head And Neck Squamous Cell Carcinoma: The Helsinki Clinical Trials.- 40. Clinical results: patients with head and neck squamous cell carcinoma who have no other treatment option.- 41. Clinical results: salivary gland cancer.- 42. BNCT for malignant pleural mesothelioma.- 43. BNCT for multiple or disseminated pleural tumors.- 44. BNCT for multiple liver metastases.- 45. Clinical results: Genital tumor.- 46. Boron Neutron Capture Therapy (BNCT) for soft tissue sarcoma.- 47. Boron Neutron Capture Therapy for Children with Malignant Brain Tumors.- 48. Application of Neutron Capture Therapy for Local Recurrent Breast Cancer .- 49. Boron Neutron Capture Synovectomy.- 50. Clinical BNCT facilities in Japan.- 51. Radiation Protection.- 52. Regulatory aspects and licensing of BNCT facilities.
| Erscheinungsdatum | 01.06.2025 |
|---|---|
| Zusatzinfo | XI, 806 p. 287 illus., 203 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren |
| Schlagworte | Boron • Boron Analysis and Imaging • : Boron neutron capture synovectomy • Californium-252 • Clinical Dosimetry • Clinical Trials • Neutron Capture Therapy (NCT) • Particle Therapy • Prompt gamma ray spectroscopy • radiation oncology • Radiation protection • Targeted therapies • Treatment Planning |
| ISBN-13 | 9783031825903 / 9783031825903 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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