Telomeres

Biomarkers of a Healthy Life and Successful Aging

Buch | Hardcover

716 Seiten

2025
Jenny Stanford Publishing (Verlag)
9789815129496 (ISBN)

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This book provides a comprehensive overview of aging and its mechanisms through the prism of telomere length and its link to lifestyle parameters and environmental pollutants, diseases where telomere length attrition is prominent, and therapeutic approaches to slow down or prevent the process of telomere length reduction. It also provides an extensive comparison of the methodology for telomere length determination and characterization. The book will help researchers in any discipline to obtain an in-depth and broad knowledge of the most recent advances in telomere research written by specialists in the field. It is also addressed to the readers interested in gaining an insight into the processes of aging and those factors that affect “graceful” aging, enabling them to extract even useful tips in improving their everyday habits.

Aristidis Tsatsakis is the director of the Department of Toxicology and Forensic Sciences at the Medical School of the University of Crete and the University Hospital of Heraklion, Greece. He is the founder and chief scientific leader of the University of Crete spinoff company ToxPlus S.A. and the startup LifePlus. Prof. Tsatsakis’ motivation logo “Toxicology addresses society’s real-life risks for sustainable health and wellbeing” is indicated on the EUROTOX 2025 website.

PART I AGING

1 Aging

PART II TELOMERE LENGTH

2 Telomere Length as a Marker of Biological Age

3 Computational Tools for Telomere Length Measurement

PART III LIFESTYLE

4 The Impact of the First 1000 Days of Human Life on Telomere Length

5 Diet as a Strategy to Lengthen Life Expectancy

6 The First Steps toward Balanced Eating

7 Fasting and Telomeres

8 The Impact of Exercise on Telomere Length

9 Telomere Shortening: A Link between Substances of Abuse and Accelerated Senescence

10 Telomere Length as Potential Metal Exposure Biomarker: State of the Art and Perspectives

PART IV DISEASES

11 Telomere’s Association with Diseases

12 Telomere Length and Metabolomics in Autoimmune Diseases

13 Osteoarthritis

14 Microbiome

15 Intestinal Microbiota and Human Telomere Length: A Dynamic Crosstalk between Two Worlds

16 Cardiovascular Diseases and Telomeres

17 Decelerating Cardiovascular Aging: Diet, Exercise, and Medication

18 Male and Female Infertility

19 Telomere Length and Human Carcinogenesis: Liable or Random Finding?

20 Telomere Length Biology in Blood Disorders and Childhood Cancer

21 Skin Aging

PART V THERAPEUTIC APPROACHES

22 Telomeres, Telomerase, and Shelterin Complex: Promising Drug Targets for Longevity, Age-Related Diseases, and Cancer

23 Therapeutic Targeting of Telomerase

Erscheinungsdatum	07.12.2024
Zusatzinfo	68 Line drawings, color; 8 Line drawings, black and white; 11 Halftones, color; 1 Halftones, black and white; 79 Illustrations, color; 9 Illustrations, black and white
Sprache	englisch
Maße	152 x 229 mm
Gewicht	1570 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
	Sozialwissenschaften ► Ethnologie
	Sozialwissenschaften ► Soziologie
ISBN-13	9789815129496 / 9789815129496
Zustand	Neuware