DNA-encoded Library Technology for Drug Discovery
Royal Society of Chemistry (Verlag)
9781788014878 (ISBN)
DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.
This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.
A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.
Purdue University, USA Dr Jin Li has over 30 years biopharmaceutical experience (at Protherics and AstraZeneca), with senior scientific and leadership roles in early stage research; as well as experience in initiating and leading major collaboration, research and outsourcing programmes. Before founding HitGen, he held Global Director positions of Compound Sciences and Computational Sciences at AstraZeneca. This included responsibility for computational chemistry, computational biology and compound collection enhancement. Dr Li completed his BSc at Sichuan University, and PhD in macromolecular sciences at Aston University. He then completed post-doctoral research in theoretical biochemistry at Manchester University, UK. Dr Li is also a Fellow of the Royal Society of Chemistry.
Overview of Affinity-based DEL Selections with Select Target Types and Achievements
Machine Learning with DEL Selection Data and for DEL design
One bead one compound (OBOC) DELs for Biochemical Screens
Live cell-based DEL Selections
On-DNA Medicinal Chemistry: Focused libraries, fragment expansion, and hit optimization
DELs with Covalent Warheads
Application of DELs for E3 Ligase Ligand and PROTAC development
| Erscheinungsdatum | 11.03.2025 |
|---|---|
| Reihe/Serie | Drug Discovery Series ; Volume 85 |
| Verlagsort | Cambridge |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 427 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| ISBN-13 | 9781788014878 / 9781788014878 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
