Targeting the DNA Damage Response for Cancer Therapy (eBook)

Timothy A. Yap, Geoffrey I. Shapiro (Herausgeber)

eBook Download: PDF

2023
328 Seiten
Springer International Publishing (Verlag)
978-3-031-30065-3 (ISBN)

Infos

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic.

Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.

Produkt-Details

• Erscheint lt. Verlag: 17.11.2023
• Reihe/Serie: Cancer Treatment and Research
• Reihe/Serie: Cancer Treatment and Research
• Zusatzinfo: X, 328 p. 30 illus., 27 illus. in color.
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Schlagworte: BRCA mutant cancers • castration-resistant prostate cancer • DNA repair pathways • Homologous recombination • Inhibition • PARP trapping • Poly (ADP-ribose) polymerase • radiosensitization • Resistance mechanisms
• ISBN-10: 3-031-30065-3 / 3031300653
• ISBN-13: 978-3-031-30065-3 / 9783031300653