The Pathogenesis of Pancreatitis
Manchester University Press (Verlag)
978-0-7190-3480-0 (ISBN)
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The second half of this century has been marked by the evolution of specialities in some branches of medicine, of which gastro-enterology has proved one of the more vigorous and successful. The development of intricate diagnostic and therapeutic techniques has fostered a tendency to overspecialization. In the past decade there has been a move to broaden the outlook. Workers who study the exocrine pancreas, both scientific and clinical, are now concerned not only with the endocrine pancreas but the liver and biliary tract as well because of the close embryological, anatomical and physiological relationships of the pancreas with these organs. In this volume, the concept of the secretory polarity of the acinar cell is reviewed and the concept of exit-block and the alternative non-regulated pathway via the basolateral membrane in pancreatitis is discussed. The possible validity of the role that oxygen-free radicals play in initiating attacks of acute pancreatitis and relapses of chronic pancreatitis is followed by reports of the Manchester preliminary trials of dietary modifications and the use of anti-oxidant supplements to reduce oxidative stress in these diseases.
The part played by leucocytes is reviewed in relation to haemorrhagic pancreatitis and cystic fibrosis of the pancreas.
Part 1 Definitions and concepts: the pathology of pancreatitis, D.S.Longnecker; the evolution of pancreatitis, J.M.Braganza; secretory polarity, O.A.Musa and R.M.Case; biological free radicals - a personal approach, T.L.Dormandy. Part 2 Initiators of acute pancreatic injury: oxygen-free radicals in experimental pancreatitis, H.Sanfey; toxicology of the pancreas, J.M.Braganza; acute mecrotizing pancreatitis and its complications - an excessive reaction of natural defence mechanisms?, H.Rinderknecht. Part 3 Effectors of chronic pancreatic damage: cytochromes P450 in chronic pancreatitis, J.B.Houston; zenobiotics in tropical chronic pancreatitis, V.Mohan and J.M.Braganza; pancreatitis in cystic fibrosis, J.A.Dodge; the exocrine pancreas in severe malnutrition, M.H.N.Golden. Part 4 Potential therapy for pancreatic disease: antioxidants in vitro and in vivo, G.Scott; antioxidant therapy of pancreatitis - clinical experience, J.M.Braganza; role of enzyme inhibitors in acute pancreatitis and rationale for their therapeutic use, K.Ohlsson and S.Genell; overview and horizons, J.M.Braganza.
| Erscheint lt. Verlag | 15.8.1991 |
|---|---|
| Vorwort | Henry T. Howat |
| Zusatzinfo | index |
| Verlagsort | Manchester |
| Sprache | englisch |
| Maße | 134 x 216 mm |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| ISBN-10 | 0-7190-3480-9 / 0719034809 |
| ISBN-13 | 978-0-7190-3480-0 / 9780719034800 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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