Molecular Mechanisms of Werner’s Syndrome

Michel Lebel (Autor)

Buch | Hardcover

156 Seiten

2004 | 2004 ed.
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-48233-5 (ISBN)

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During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.

1. Clinical Aspects of Werner’s Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner’s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner’s Syndrome.

Erscheint lt. Verlag	14.9.2004
Zusatzinfo	X, 156 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
ISBN-10	0-306-48233-9 / 0306482339
ISBN-13	978-0-306-48233-5 / 9780306482335
Zustand	Neuware