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The Maudsley Prescribing Guidelines in Psychiatry (eBook)

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2021 | 14. Auflage
John Wiley & Sons (Verlag)
978-1-119-77223-1 (ISBN)

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The Maudsley Prescribing Guidelines in Psychiatry - David M. Taylor, Thomas R. E. Barnes, Allan H. Young
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The Maudsley® Prescribing Guidelines in Psychiatry

The new edition of the world-renowned reference guide on the use of medications for patients presenting with mental health problems

The Maudsley Prescribing Guidelines in Psychiatry is the essential evidence-based handbook on the safe and effective prescribing of psychotropic agents. Covering both common and complex prescribing situations encountered in day-to-day clinical practice, this comprehensive resource provides expert guidance on drug choice, minimum and maximum doses, adverse effects, switching medications, prescribing for special patient groups, and more. Each clear and concise chapter includes an up-to-date reference list providing easy access to the evidence on which the guidance is based.

The fourteenth edition has been fully updated to incorporate the latest available research, the most recent psychotropic drug introductions, and all psychotropic drugs currently used in the UK, USA, Canada, Australia, New Zealand, and Japan. Several new sections cover topics such as deprescribing of major psychiatric drugs, prescribing psychotropics at the end of life, the treatment of agitated delirium, the genetics of clozapine prescribing, the use of weekly penfluridol, and the treatment of psychotropic withdrawal. Featuring contributions by an experienced team of psychiatrists and specialist pharmacists, the new edition of The Maudsley Prescribing Guidelines in Psychiatry:

  • Provides succinct coverage of drug treatment of psychiatric conditions and formulating prescribing policy in mental health
  • Covers a wide range of psychiatric conditions including schizophrenia, bipolar disorder, depression and anxiety, borderline personality, eating disorders, and many others
  • Provides advice on prescribing for children and adolescents, older people, pregnant women, and other special patient groups
  • Offers new sections on genetic prescribing, long-acting injectable formulations, ketamine administration and uses, and dopamine super-sensitivity
  • Includes referenced information on off-label prescribing, potential interactions with other substances such as alcohol, tobacco, and caffeine, and treating patients with comorbid physical conditions

Whether in the doctor's office, in the clinic, or on the ward, The Maudsley Prescribing Guidelines in Psychiatry, Fourteenth Edition is a must-have for psychiatrists, pharmacists, neuropharmacologists, clinical psychologists, nurses, and other healthcare professionals working in mental health, as well as trainees and students in medicine, pharmacy, and nursing.



David M. Taylor, BSc, MSc, PhD, FFRPS, FRPharmS, FRCPsych (Hon) is Director of Pharmacy and Pathology at the Maudsley Hospital and Professor of Psychopharmacology at King's College, London.

Thomas R. E. Barnes, MBBS, MD, FRCPsych, DSc, is Emeritus Professor of Clinical Psychiatry at Imperial College London and joint-head of the Prescribing Observatory for Mental Health at the Royal College of Psychiatrists' Centre for Quality Improvement.

Allan H. Young, MB, ChB, MPhil, PhD, FRCPC, FRCPsych, is Chair of Mood Disorders and is Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry at King's College London, UK.

David M. Taylor, BSc, MSc, PhD, FFRPS, FRPharmS, FRCPsych (Hon) is Director of Pharmacy and Pathology at the Maudsley Hospital and Professor of Psychopharmacology at King's College, London. Thomas R. E. Barnes, MBBS, MD, FRCPsych, DSc, is Emeritus Professor of Clinical Psychiatry at Imperial College London and joint-head of the Prescribing Observatory for Mental Health at the Royal College of Psychiatrists' Centre for Quality Improvement. Allan H. Young, MB, ChB, MPhil, PhD, FRCPC, FRCPsych, is Chair of Mood Disorders and is Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry at King's College London, UK.

Preface xi

Acknowledgments xii

Notes on using The Maudsley Prescribing Guidelines in Psychiatry xiii

List of abbreviations xv

Part 1 Drug treatment of major psychiatric conditions 1

Chapter 1 Schizophrenia and related psychoses 3

ANTIPSYCHOTIC DRUGS 3

ANTIPSYCHOTIC ADVERSE EFFECTS 109

REFRACTORY SCHIZOPHRENIA AND CLOZAPINE 190

CLOZAPINE ADVERSE EFFECTS 212

Chapter 2 Bipolar disorder 247

Chapter 3 Depression and anxiety disorders 305

Chapter 4 Addictions and substance misuse 451

Part 2 Drug treatment of special patient groups 537

Chapter 5 Children and adolescents 539

Chapter 6 Prescribing in older people 601

Chapter 7 Pregnancy and breastfeeding 679

Chapter 8 Hepatic and renal impairment 723

Part 3 Prescribing in specialist conditions 755

Chapter 9 Drug treatment of other psychiatric conditions 757

Chapter 10 Drug treatment of psychiatric symptoms occurring in the context of other disorders 777

Part 4 Other aspects of psychotropic drug use 831

Chapter 11 Pharmacokinetics 833

Chapter 12 Other substances 865

Chapter 13 Psychotropic drugs in special conditions 875

Chapter 14 Miscellany 897

Index 943

List of abbreviations


AACAP American Academy of Child and Adolescent Psychiatry
ACE angiotensin‐converting enzyme
ACh acetylcholine
AChE acetylcholinesterase
AChE‐I acetylcholinesterase inhibitor
ACR albumin: creatinine ratio
AD Alzheimer’s disease
ADAS‐cog Alzheimer’s Disease Assessment Scale – cognitive subscale
ADH alcohol dehydrogenase
ADHD attention deficit hyperactivity disorder
ADIS Anxiety Disorders Interview Schedule
ADL activities of daily living
ADR adverse drug reaction
AF atrial fibrillation
AIDS acquired immune deficiency syndrome
AIMS Abnormal Involuntary Movement Scale
ALP alkaline phosphatase
ALT alanine transaminase/aminotransferase
ANC absolute neutrophil count
ANNSERS Antipsychotic Non‐Neurological Side‐Effects Rating Scale
APA American Psychological Association
ARB angiotensin II receptor blocker
ASD autism spectrum disorders
ASEX Arizona Sexual Experience Scale
AST aspartate aminotransferase
AUDIT Alcohol Use Disorders Identification Test
BAC blood alcohol concentration
BAP British Association for Psychopharmacology
BBB blood–brain barrier
bd bis die (twice a day)
BDD body dysmorphic disorder
BDI Beck Depression Inventory
BDNF brain‐derived neurotrophic factor
BED binge eating disorder
BEN benign ethnic neutropenia
BMI body mass index
BN bulimia nervosa
BP blood pressure
BPD borderline personality disorder
BPSD behavioural and psychological symptoms of dementia
BuChE butyrylcholinesterase
CAM Confusion Assessment Method
CAMS Childhood Anxiety Multimodal Study
CATIE Clinical Antipsychotic Trials of Intervention Effectiveness
CBT cognitive behavioural therapy
CBZ carbamazepine
CDRS Children’s Depression Rating Scale
CDT carbohydrate‐deficient transferrin
CES‐D Centre for Epidemiological Studies Depression scale
CGAS Children’s Global Assessment Scale
CGI Clinical Global Impression scales
CI confidence interval
CIBIC‐Plus Clinician’s Interview‐Based Impression of Change
CIGH clozapine‐induced gastrointestinal hypomotility
CIWA‐Ar Clinical Institute Withdrawal Assessment of Alcohol scale revised
CK creatine kinase
CKD chronic kidney disease
CKD‐EPI Chronic Kidney Disease Epidemiology Collaboration
CNS central nervous system
COMT catechol‐O‐methyltransferase
COPD chronic obstructive pulmonary disease
COX cyclo‐oxygenase
CPK creatinine phosphokinase
CPP child–parent psychotherapy
CPSS Child PTSD Symptom Scale
CrCl creatinine clearance
CREB cAMP response element‐binding protein
CRP C‐reactive protein
CUtLASS Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study
CVA cerebrovascular accident
CY‐BOCS Children’s Yale‐Brown Obsessive Compulsive Scale
CYP cytochrome P
DAI drug attitude inventory
DESS Discontinuation–Emergent Signs and Symptoms scale
DEXA dual‐energy X‐ray absorptiometry
DHEA dehydroepiandrosterone
DIVA Diagnostic Interview for DSM‐IV ADHD
DLB dementia with Lewy bodies
DMDD disruptive mood dysregulation disorder
DOAC direct‐acting oral anticoagulant
DoLS Deprivation of Liberty Safeguards
DSM Diagnostic and Statistical Manual of Mental Disorders
DVLA Driver and Vehicle Licensing Agency
EAD early after depolarisation
ECG electrocardiogram
ECT electroconvulsive therapy
EDTA ethylenediaminetetraacetic acid
EEG electroencephalogram
eGFR estimated glomerular filtration rate
EMDR eye movement desensitisation and reprocessing
EOSS early‐onset schizophrenia‐spectrum
EPA eicosapentanoic acid
EPS extrapyramidal symptoms
ER extended release
ERK extracellular signal‐regulated kinase
ERP exposure and response prevention
ES effect size
ESR erythrocyte sedimentation rate
FAST functional assessment staging
FBC full blood count
FDA Food and Drug Administration (USA)
FGA first‐generation antipsychotic
FPG fasting plasma glucose
FTI Fatal Toxicity Index
GABA γ‐aminobutyric acid
GAD generalised anxiety disorder
GASS Glasgow Antipsychotic Side‐effect Scale
GBL gamma-butyrolactone
G‐CSF granulocyte colony‐stimulating factor
GFR glomerular filtration rate
GGT γ‐glutamyl transferase
GHB γ‐hydroxybutyrate
GI gastrointestinal
GM‐CSF granulocyte‐macrophage colony-stimulating factor
GSK3 glycogen synthase kinase 3
HADS Hospital Anxiety and Depression Scale
HAMA Hamilton Anxiety Rating Scale
HAND HIV‐associated neurocognitive disorders
HD Huntington’s disease
HDL high‐density lipoprotein
HDRS Hamilton Depression Rating...

Erscheint lt. Verlag 13.7.2021
Reihe/Serie The Maudsley Prescribing Guidelines Series
The Maudsley Prescribing Guidelines Series
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Medizinische Fachgebiete Psychiatrie / Psychotherapie
Schlagworte Clinical psychology • Klinische Psychologie • Medical Science • Medizin • Pharmacy • Pharmazie • psychiatric drug treatment • psychiatric prescribing guide • Psychiatrie • Psychiatry • psychiatry prescribing • psychiatry prescribing handbook • psychiatry prescribing reference • Psychologie • Psychology • psychotropic drug adverse effects • psychotropic drug interactions • psychotropic prescribing
ISBN-10 1-119-77223-0 / 1119772230
ISBN-13 978-1-119-77223-1 / 9781119772231
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