Free Radicals and Inhalation Pathology

Respiratory System, Mononuclear Phagocyte System - Hypoxia and Reoxygenation - Pneumoconioses and other Granulomatoses - Cancer

Erich Schiller (Autor)

Media-Kombination

XXI, 773 Seiten

2003 | 1., Aufl.
Springer Berlin
978-3-540-00201-7 (ISBN)

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This book summarizes highlights in the field of free radicals in medicine and biology, with a detailed analysis of the extensive recent literature. It describes results from experimental research work on dust inhalation, hypoxia, and environmental toxicology that uses morphologic methods such as electron microscopy, interference microscopy and time-lapse techniques in tissue cultures. The volume discusses free radical reactions that are probably involved in the pathogenesis of both physical and chemical environmental hazards. It lists radical scavengers that function as useful prophylactic agents in case of unavoidable exposure. A short history of dust diseases that have challenged mankind since prehistoric times serves as an introduction to this comprehensive treatise. It is hoped that by covering this field in one monograph the increasingly recognized and important role of both oxygen- and nitrogen-centred radicals in disease pathogenesis will become clearer. The enclosed CD includes nearly 25.000 literature citations useful as a reference source for researchers, clinicians and students.

Part I History and Scientific Background: Introduction.- Protagonists of Industrial Medicine.- Aetiopathogenesis of Pulmonary Fibrosis and Malignancy.- Formulation of the Problems.- Material and Methods.- Reactive Oxygen and Nitrogen Species.- Part II Respiratory System: Orthology and Pathology: Tracheo-bronchial Epithelium.- Pneumocytes.- Alveolar Macrophages.- Interstice.- Pulmonary Blood Vessels.- Pulmonary Lymphatic Vessels.- Pulmonary Nerves.- Radical-Mediated Pulmonary Lesions.- Part III Extrapulmonary Targets: Radical Damage in Nonrespiratory Organ Systems.- Part IV Ageing: Molecular Ageing.- Ageing of Organs.- Possible Strategies to Prevent and Reverse Manifestations of Ageing.- Part V Cancer: Tumour Proliferation and Metastasis.- Antitumour Drug Therapy.- Epilogue.- Subject Index

Vorwort	W. Kriz, H. Bartsch
Zusatzinfo	mit 1 CD-ROM
Sprache	englisch
Maße	193 x 270 mm
Gewicht	2295 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Schlagworte	Environmental pathology • Granulomas • HC/Medizin/Klinische Fächer • Histobiology • inflammation • Lung • Pathologie • Reactive oxygen and nitrogen species
ISBN-10	3-540-00201-4 / 3540002014
ISBN-13	978-3-540-00201-7 / 9783540002017
Zustand	Neuware