X-Ray Phase-Contrast Tomography

Underlying Physics and Developments for Breast Imaging

Luca Brombal (Autor)

Buch | Hardcover

XIII, 140 Seiten

2020
Springer International Publishing (Verlag)
9783030604325 (ISBN)

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X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals.

Introduction.- Physics of Propagation-based X-ray Tomography.- Propagation-based Breast CT and SYRMA-3D Project.- Detector and Pre-processing.- Experimental Optimization of Propagation-based BCT.- Three-Dimensional Imaging: A Clinically Oriented Focus.- Do We Need Clinical Applications in Synchrotrons?.- Conclusions.

Erscheinungsdatum	18.11.2020
Reihe/Serie	Springer Theses
Zusatzinfo	XIII, 140 p. 68 illus., 53 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	407 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
Schlagworte	Breast CT • Breast Imaging • Clinical Application of Synchrotron • Computed tomography • phase-contrast tomography • Propagation-Based Imaging • Synchrotron radiation • x-ray imaging • X-Ray Phase Contrast
ISBN-13	9783030604325 / 9783030604325
Zustand	Neuware