Extracellular Matrix Remodeling

Buch | Softcover

428 Seiten

2019
MDPI (Verlag)
9783039216284 (ISBN)

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The extracellular matrix (ECM) is where cells live. It is composed of collagen and elastic fibers, glycosaminoglycans and proteoglycans, and several glycoproteins. In most tissues, fibril-forming collagen type I is the major constituent of ECM.The function of the ECM goes beyond providing mechanical support to cells and tissues. As cells are embedded into the ECM and interact with its components through their surface receptors, cell–ECM interaction plays a key role in influencing different cell activities, such as cell proliferation and migration. The ECM also sequesters and releases growth factors affecting important cellular pathways. Overall, the ECM strongly influences and affects cell behavior and tissue homeostasis.
ECM is a highly dynamic structural network that continuously undergoes controlled remodeling mediated by matrix-degrading enzymes, the matrix metalloproteinases (MMPs), under normal conditions.
Quantitative and qualitative deregulation of ECM remodeling and, especially, of collagen turnover, is responsible for the alteration of ECM composition and structure, associated with the development and progression of several pathological conditions, such as organ fibrosis (determined by the abnormal accumulation of ECM components) and tumor invasion.
The understanding of the diverse biological roles and properties of the ECM components is pivotal to the development of new therapeutic tools for disease treatment.

Erscheinungsdatum	24.11.2019
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Schlagworte	1,2-Dichloroethane poisoning • 2-Chloroethanol • Acid Phosphatase • activator protein-1 • acute respiratory distress syndrome • Adipose tissue • Advanced Glycation End Products • aging • Anabolic Androgenic Steroids • anticoagulation • Apoptosis • arterial wall • Articular Cartilage • Asthma • autophagy • biased signaling • Biomechanics • Birefringence • birefringent collagen • Breast Cancer • Cancer • cathepsin • Ccni • Cell Migration • cell senescence • chondrocyte RNA-Seq • chondrocytes • chondrogenesis • Chronic Obstructive Pulmonary Disease • Circulating Biomarkers • Cirrhosis • Collagen • Collagenase • collagen turnover • cyclin-dependent kinase 9 • cytokines • Cytoskeleton • Dedifferentiation • Diagnosis • E-cadherin • ECM accumulation • EGFR • Endothelial Dysfunction • Epithelial-to-mesenchymal transition • eruptive pathway • extracellular matrix • extracellular matrix degradation • extracellular matrix (ECM) • extracellular matrix remodeling • fibrocytes • Fibrosis • Focal Adhesion • functional selectivity • gait • G-CSF • gemma • gene expression • germinal epithelium • Glucose • gonad • GPCR • GPCR bias agonism • Greater Trochanter Pain Syndrome • Heparanase • Hepatitis • Hyaluronan • Hypertrophic Cardiomyopathy • IL-6 • inflammation • inflammation associated disease • insulin receptor • insulin resistance • lamina propria • Liver • lung function • matrix metalloproteases • matrix metalloproteinase-1 • matrix metalloproteinase 15 expression • Matrix Metalloproteinases • matrix metalloproteinases-9 • medaka • Megakaryocyte • Metabolomics • Metalloproteinase • metalloproteinases • microRNA • MMP-crosstalk • MMPs • nuclear factor-κB • nuclear progestin receptor phosphorylation • Oncostatin M • osteopontin • Osteoporosis • Ovulation • p38 MAPK signal pathway • physioxia • prognosis • protease-activated receptors • Proteomics • protogynous diandric fish • Repair • Resistance training • RNA-Seq • scaffold • Skeletal muscle • Surgery • synoviocyte matrix • Tendinopathy • Tendon • tenomodulin • Thrombin • thrombopoiesis • toll-like receptor • Ultrastructure • von Willebrand factor • Wound
ISBN-13	9783039216284 / 9783039216284
Zustand	Neuware