G-quadruplex and Microorganisms

Buch | Softcover

208 Seiten

2019
MDPI (Verlag)
978-3-03921-243-9 (ISBN)

Keine Verlagsinformationen verfügbar

Artikel merken

G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.

Erscheinungsdatum	16.09.2019
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Alphaherpesvirinae • alphaherpesviruses • Aptamers • Bacteria • Bioinformatics • Conformational dynamics • co-transcriptional folding • co-translational refolding • Deinococcus • DNA • EBNA1 • Epstein-Barr virus (EBV) • eukaryotic hosts • fluorescence • Folding • G4 • G4Hunter • Genome • Genome Evolution • Genome Stability • G-QUADRUPLEX • G-quadruplexes • G-quadruplex formation • G-quadruplex ligand • Herpesviridae • Herpesvirus • human papillomaviruses • immediate early promoters • Metastable structure • microbes • NDPK • NMR • Nucleic acids • nucleic acids conformation • nucleoside diphosphate kinase • PhenDC3 • protein–DNA interaction • protein-mRNA interactions • Protozoa • pseudorabies virus • pyridostatin • RecQ helicase • regulatory element • S. cerevisiae • Structure • Structure-activity Relationship • translation suppression • turn-on ligands • Virus
ISBN-10	3-03921-243-5 / 3039212435
ISBN-13	978-3-03921-243-9 / 9783039212439
Zustand	Neuware