New Advances on Zika Virus Research

Luis Martinez-Sobrido, Fernando Almazan Toral (Herausgeber)

Buch | Softcover

552 Seiten

2019
MDPI (Verlag)
978-3-03897-764-3 (ISBN)

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Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Erscheinungsdatum	05.03.2022
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
Schlagworte	Aedes aegypti • African-lineage • Antiviral • antiviral compounds • anti-viral immunity • Antiviral responses • antivirals • Apoptosis • arbovirus • Asian lineage • Asian-lineage • assay standardization • astrocytomas • Bacterial artificial chromosome • Bayesian analyses • blood-retinal barrier • boolean logic-processing nucleic acid probes • Cell Surface Receptors • chimeric viruses • Clinical Trials • congenital Zika syndrome • cross-reactions • cryptic promoter silencing • cytopathic effects • Dengue virus • dengue viruses • detoxification and immune system responses • Diagnosis • dsRNA • eIF4A • ELISA • emerging arbovirus • EQA • external quality assessment • Eye • fetal infection • flavivirus • flaviviruses • FSS13025 • Full-length cDNA infectious clones • full-length molecular clone • gene expression • genetic variability • heme-oxygenase 1 • Hepatocytes • host-directed antivirals • host genetic variation • human brain glial cells • iga • IgG avidity tests • immune response • indirect immunofluorescence • Infection • infectious cDNA • infectious clone • infectious RNA • innate response • Insecticide Resistance • isothermal nucleic acid amplification • laboratory preparedness • Microcephaly • microglia cells • MicroRNAs • microsphere immunoassay • Molecular Diagnostics • monoclonal antibodies • Mosquito • mosquito-borne flavivirus • mosquito surveillance • MR766 • multiplex nucleic acid detection • Mutagenesis • Natural History • neural cells • neural progenitor cells • Neuroinflammation • neurons • Neuropathogenesis • NHP • Non-human primates • NS1 protein • NS2A protein • NS5 • nucleic acid computation • nucleic acid strand exchange • Ocular • optimised • outbreak control • placenta cells • plaque reduction neutralization test • plasmid toxicity • point-of-care diagnostics • Polymerase chain reaction • Pregnancy • prM-E proteins • Prostate • QCMD • Replication • replicon • reporter virus • research models and tools • Reverse Genetics • Rhesus macaques • RNA-Seq • secondary infections • Serology • Sexual transmission • silvestrol • siRNA • subgenomic replicon • testes • testicular cells • Testis • Tet-inducible • therapeutics • therapy • TLR7/8 • type I IFN antagonist • vaccines • validated • viral counteraction • Viral evolution • viral fitness • viral genetic variation • viral pathogenesis • viral pathogenicity • viral permissiveness • viral persistence • Viral Replication • viral survival • virus attachment • virus like particles • Zika • zika virus • Zika virus (ZIKV) • Ziks virus • ZIKV • ZIKV-associated neurologic disorders • ZIKV–host interactions
ISBN-10	3-03897-764-0 / 3038977640
ISBN-13	978-3-03897-764-3 / 9783038977643
Zustand	Neuware