Human Metabolism (eBook)

A Regulatory Perspective

Rhys Evans, Keith N. Frayn (Autoren)

eBook Download: EPUB

2019 | 4. Auflage
392 Seiten
Wiley (Verlag)
978-1-119-33146-9 (ISBN)

Infos

The updated bestselling guide to human metabolism and metabolic regulation

The revised and comprehensively updated new edition of Human Metabolism (formerly Metabolic Regulation - A Human Perspective) offers a current and integrated review of metabolism and metabolic regulation. The authors explain difficult concepts in clear and concise terms in order to provide an accessible and essential guide to the topic. This comprehensive text covers a wide range of topics such as energy balance, body weight regulation, exercise, and how the body copes with extreme situations, and illustrates how metabolic regulation allows the human body to adapt to many different conditions.

This fourth edition has been revised with a new full colour text design and helpful illustrations that illuminate the regulatory mechanisms by which all cells control the metabolic processes necessary for life. The text includes chapter summaries and additional explanatory text that help to clarify the information presented. In addition, the newly revised edition includes more content on metabolic pathways and metabolic diseases. This important resource:

• Is a valuable tool for scientists, practitioners and students across a broad range of health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing
• Includes a full colour text filled with illustrations and additional diagrams to aid understanding
• Offers a companion website with additional learning and teaching resources.

Written for students of medicine, biochemistry, nutrition, dietetics, sports science and nursing, Human Metabolism has been revised and updated to provide a comprehensive review of metabolism and metabolic regulation.

Keith N. Frayn, Emeritus Professor of Human Metabolism, University of Oxford, UK.

Rhys D. Evans, Reader in Metabolic Biochemistry, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

Inhalt

Preface vi

Abbreviations vii

About the companion website xi

1 The underlying principles of human metabolism 1

2 Cellular aspects of metabolic regulation 48

3 Coordination of metabolism in the whole body 76

4 Digestion and intestinal absorption 93

5 Metabolic specialisation of organs and tissues 118

6 Communication systems 173

7 Integration of carbohydrate, fat and protein metabolism in normal daily life 204

8 Metabolic challenges: Coping with some extreme physiological situations 245

9 Metabolic challenges: Coping with some pathological situations 277

10 Lipoprotein metabolism and atherosclerosis 302

11 Energy balance and body weight regulation 325

12 Diabetes mellitus 346

Index 365

Rezensionen

Praise for the 4th edition

"Frayn and Evans have done a marvellous job of updating this textbook to reflect recent developments in metabolic research ... I now have the relatively simple task of updating my reading list for this coming year's lectures to recommend this terrific new edition." (Physiology News Autumn 2019, Issue 116)

"This textbook has been a masterpiece since the first edition ... by giving a superb explanation of human metabolism to range a wide readers and students. "Human Metabolism" has remained a favorite reference for many teachers of students of a variety of medical programs be it medicine, nursing or biochemistry ... With each edition the book has improved by providing up to date information in a key and basic field of medicine where knowledge has been moving very fast in the last 25 years." (Clinical Nutrition)

"Based on its highly regarded predecessor - Metabolic Regulation: A Human Perspective - this book has been given a noticeable overhaul in both content and title. Unlike the many other texts available that are dominated by the intricacies of biochemistry, this book seeks to offer readers from clinical and sports science backgrounds practical insights into human metabolism ... The authors' relaxed writing styles make reading about complex themes interesting and, dare I say it, fun ... The readability also extends to the layout, which is uncluttered and easy to navigate. Abundant colourful diagrams interspersed throughout succeed in consolidating the knowledge conveyed narratively in the text ... Human Metabolism is undoubtedly a highly readable resource that will have broad appeal for those with an interest in physiology and nutrition. Overall, I would certainly recommend it as a useful addition to any trainee's library." (The Bulletin of the Royal College of Pathologists)

Praise for the previous edition

"I had the great pleasure of reading your impressive text. While I realize that your intended market is certainly not people such as myself (I read it to better understand my own health and body), it is surprisingly well suited for that purpose: being both dense in useful information and surprisingly accessible to non-specialist readers. I appreciated several things about your book -- that you kept the text relatively short for an academic text; that you made it largely self-contained (I especially appreciate your care in providing internal cross references in the book); that you put much of the content into tables, boxes, and diagrams ... I learned a great deal from the book, and it has substantially increased the quality of my interactions with my own physician" (Doug Tygar, Professor of Computer Science & Information, UC Berkeley, USA)

"It is hard to find a textbook that gives a better basis for the understanding of Human metabolism and nutrition, that is so well designed and actually quite fun to read as this one. This book is my first choice for a textbook for my medical students and for nursing school too. It is well suited for any kind of studies of metabolism at a higher level because of its ease at explaining the basics and the frameworks needed for the understanding of metabolism. It is the first book I give to my doctorial students when they need to freshen up their knowledge and the basics in metabolism when starting research in clinical nutrition and metabolism...if anyone is looking for the most interesting and fun book to read as an in depth introduction to human metabolism and nutrition, this is it!" (Clinical Nutrition)

Textauszug

Abbreviations

Some abbreviations used only within a figure, table or box, and defined there, are not included here. Some abbreviations are given in the text not because the terms are used frequently, but because the substance in question is often better known by its abbreviation. In such cases, if the abbreviation only occurs in one limited section, it will not be listed here.

ABC (G5, G8, etc.)

ATP-binding cassette-containing protein-G5, G8 etc.

ACAT	acyl-Coenzyme A: cholesterol acyltransferase

ACC	acetyl-CoA carboxylase

ACCORD

Action to Control Cardiovascular Risk in Diabetes

ACE	angiotensin-converting enzyme

ACS	acyl-CoA synthase

ACSL	long-chain acyl-CoA synthase

ACTH	adrenocorticotrophic hormone (corticotrophin)

ADH	antidiuretic hormone

ADP	adenosine 5′-diphosphate

AEE	activity energy expenditure

AGE	advanced glycation end-product

AgRP	Agouti-related protein

AIDS	Acquired ImmunoDeficiency Syndrome

ALT	alanine aminotransferase

AMP	adenosine 5′-monophosphate

AMPK	AMP-activated protein kinase

ANP	atrial natriuretic peptide

APOA, B, C, E, etc.

apolipoprotein A,B,C,E, etc.

ARB	angiotensin receptor blocker

AST	aspartate aminotransferase

ATGL	adipose triacylglycerol (or triglyceride) lipase

ATP	adenosine 5′-trisphosphate

BAT	brown adipose tissue

BCAA	branched chain amino acid

BCAT	branched chain amino acid aminotransferase

BCKD(C)

branched chain 2-oxoacid (α-ketoacid) dehydrogenase (complex)

BMCP1

brain mitochondria carrier protein 1

BMI	body mass index

BMR	basal metabolic rate

BNP	brain natriuretic peptide

cAMP	cyclic adenosine 3′, 5′-monophosphate (cyclic AMP)

CARS	compensatory anti-inflammatory response syndrome

CAT-1, 2

carnitine-acyl transferase-1, 2

CCK	cholecystokinin

CETP	cholesteryl ester transfer protein

cGMP	cyclic guanosine 3′, 5′-monophosphate (cyclic GMP)

CHD	coronary heart disease

ChRE	carbohydrate response element

ChREBP

carbohydrate response element binding protein

CIM	critical illness myopathy

CIP	critical illness polyneuropathy

CNP	C-type natriuretic peptide

CNS	central nervous system

CoA	coenzyme A

CoASH

coenzyme A reduced form

CoQ10

ubiquinone

CPT-1, 2

carnitine-palmitoyl transferase-1, 2

CSII	continuous subcutaneous insulin infusion

DHA	docosahexaenoic acid (22 : 6 n-3)

D-2HG

D-2-hydroxyglutarate

DIT	diet-induced thermogenesis

DPP	Diabetes Prevention Program

EDRF	endothelial-derived relaxing factor

EE	energy expenditure

eIF	eukaryotic initiation factor

eNOS	endothelial NO synthase

ER	endoplasmic reticulum

ERK	extracellular signal-regulated kinase

FABP(pm)

fatty acid binding protein (plasma membrane isoform)

FAD	flavin adenine dinucleotide (oxidised form)

FADH2

flavin adenine dinucleotide (reduced form)

FAT	fatty acid translocase

FATP	fatty acid transport protein

FFM	fat-free mass

FGF	fibroblast growth factor

FH	familial hypercholesterolaemia

FIL	feedback inhibitor of lactation

FoxO	Forkhead box ‘Other’

FQ	food quotient

FSH	follicle-stimulating hormone

FXR	farnesoid X-receptor

G	Gibbs ‘free’ energy

G6-P	glucose 6-phosphate

GDP	guanosine 5′-diphosphate

GH	growth hormone

GHSR	growth hormone secretagogue receptor

GIP	gastric inhibitory polypeptide, also known as glucose-dependent insulinotrophic polypeptide

GK	glucokinase

GLP (1 and 2)

glucagon-like peptide-1 and -2

GLUT	glucose transporter

GOAT	ghrelin-O-acyltransferase

GPAT	glycerol phosphate-acyl transferase

GPCR	G protein-coupled receptor

GPIHBP1

glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

GR	glucocorticoid receptor

GSK	glycogen synthase kinase

GTP	guanosine 5′-trisphosphate

HDAC	histone deacetylation/deacetylase

HDL	high density lipoprotein

HIF-1

hypoxia-inducible factor-1

HIV	Human Immunodeficiency Virus

HK	hexokinase

HMG-CoA

3-hydroxy-3-methylglutaryl-CoA

hPL	human placental lactogen

HSL	hormone-sensitive lipase

5-HT	5-hydroxytryptamine

IDDM	insulin-dependent diabetes mellitus

IGF	insulin-like growth factor

IL	interleukin

IMM	inner mitochondrial membrane

JAK	originally Just Another Kinase; redesignated JAnus Kinase

Ka	dissociation constant for an acid

Km	Michaelis constant

LADA	latent autoimmune diabetes in adults

LCAD	long-chain acyl CoA dehydrogenase

LCAT	lecithin-cholesterol acyltransferase

LDL	low-density lipoprotein

LH	luteinising hormone

LPL	lipoprotein lipase

LXR	liver X-receptor

MAPK	mitogen-activated protein kinase

MET	(unit of work): 1 MET =...

Produkt-Details

• Erscheint lt. Verlag: 19.3.2019
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: Ernährung • Ernährung u. Diätetik • Gesundheits- u. Sozialwesen • Health & Social Care • medical biochemistry • Medical Science • Medizin • Medizinische Biochemie • Metabolism & Biochemistry of Nutrition • Nutrition & Dietetics General • Stoffwechsel • Stoffwechsel u. Biochemie der Ernährung
• ISBN-10: 1-119-33146-3 / 1119331463
• ISBN-13: 978-1-119-33146-9 / 9781119331469