Introduction to Pharmaceutical Analytical Chemistry (eBook)

Bente Gammelgaard, Trine G. Halvorsen, Stig Pedersen-Bjergaard (Autoren)

eBook Download: EPUB

2019 | 2. Auflage
544 Seiten
Wiley (Verlag)
978-1-119-36275-3 (ISBN)

Infos

The definitive textbook on the chemical analysis of pharmaceutical drugs ­- fully revised and updated 

Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.

This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.

• Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics
• Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject
• Examines various analytical techniques commonly used in pharmaceutical laboratories
• Provides practice problems, up-to-date practical examples and detailed illustrations
• Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines 

Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical chemists transitioning into the field of pharmaceutical analytical chemistry.

STIG PEDERSEN-BJERGAARD is Professor at the Department of Pharmacy, University of Oslo and Professor at the Department of Pharmacy, University of Copenhagen.

BENTE GAMMELGAARD is Professor at the Department of Pharmacy, University of Copenhagen.

TRINE GRØNHAUG HALVORSEN is Associate Professor at the Department of Pharmacy, University of Oslo.

Textauszug

Symbols and Units

 

The units in the book do not strictly follow the SI units. The units are adjusted to the dimensions in analytical work.

 

Symbol

Unit

A

Absorbance

—

A(1%, 1 cm)

Specific absorbance

—

AS

Symmetry factor

—

a

Activity

—

α

Relative retention (separation factor)

—

Specific optical rotation

(°) degrees

c

Concentration

g/L, mol/L

d

Dextrorotary (optical rotation)

° (degrees)

D

Distribution ratio (also named distribution coefficient or partition coefficient)

—

E

Potential

V

E

Electrical field (CE)

V/cm

E0

Standard electrode potential (standard reduction potential)

V

ε

Molar absorption coefficient

cm−1 · mol−1 · L

εo

Relative elution strength

—

η

Viscosity

cPoise

F

Flow rate (chromatography)

mL/min

F

Fluorescence

—

h

Peak height

mm

H

Height equivalent to theoretical plate

I

Intensity

—

IA

Acid value

mg

II

Iodine value

mg

IOH

Hydroxyl value

mg

IS

Saponification value

mg

Ka

Acid ionization constant (= acid dissociation constant, acidity constant)

M

Kb

Base ionization constant (= basicity constant)

M

KD

Partition ratio (= distribution constant)

Kw

Autoprotolysis equilibrium constant of water (= ion product of water)

M2

k

Retention factor

—

λ

Wavelength

nm

L

Length

m (mm)

l

Levorotary (optical rotation)

° (degrees)

μapp

Apparent mobility

cm2 · min−1 · V−1

μe

Electrophoretic mobility

cm2 · min−1 · V−1

μeo

Electroosmotic mobility

cm2 · min−1 · V−1

M

Molarity

mol /L−1

M

Molar mass

g/mol

M

Molecular mass

u = Da

Mr

Relative molar mass

—

N

Number of theoretical plates

—

ν

Frequency

Hz (s−1)

pI

Isoelectric point

—

P

Distribution ratio between 1‐octanol and aqueous solution, pH 7.4

—

P′

Polarity index

—

φ

Quantum yield (fluorescence)

—

r

Radius

m (mm)

Rf

Retention factor (TLC)

—

RS

Resolution (chromatography)

—

ρ

Density

g/cm3

σ

Standard deviation

—

s

Standard deviation

T

Temperature

K, C

T

Transmittance

—

tR

Retention time

min

tM

Hold‐up time

min

t′R

Adjusted retention time

min

u

Linear velocity (flow rate)

cm/s

v

Velocity

m/s

V

Volume

L, 1 mL = 1 cm3

VM

Hold‐up volume (void volume) (LC); total permeation volume (SEC)

mL

VO

Exclusion volume

mL

VR

Retention volume

mL

W

Peak width

min

Wh

Peak width at half height

min

Mean

—

z

Charge

—

Constants

Avogadro's number

N

6.0221 × 1023 mol−1

Faraday's constant

F

9.649 × 104 · C(oulomb) · mol−1 = 96.485 kJ · mol−1

Gas constant

R

8.314 J · K−1 · mol−1

Speed of light in vacuum

c

2.998 × 108 m/s

Planck's...

Produkt-Details

• Erscheint lt. Verlag: 11.2.2019
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Pharmazie ► PTA / PKA
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• Schlagworte: Analytical Chemistry • Analytische Chemie • Biowissenschaften • Chemie • Chemistry • Forensic Science • Forensik • Life Sciences • Pharmaceutical & Medicinal Chemistry • Pharmazeutische Chemie • Pharmazeutische u. Medizinische Chemie
• ISBN-10: 1-119-36275-X / 111936275X
• ISBN-13: 978-1-119-36275-3 / 9781119362753