Mechanisms of Drug Resistance in Cancer Therapy

Mario Mandalà, Emanuela Romano (Herausgeber)

Buch | Hardcover

VIII, 297 Seiten

2019 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-030-10506-8 (ISBN)

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A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.

1. Molecular and Pharmacological Mechanisms of Drug Resistance: An Evolving Paradigm.- 2. Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival.- 3. Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies.- 4. Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer.- 5. Mechanisms of Drug Resistance in Melanoma.- 6.Mechanisms of Resistance to Immune Checkpoint Antibodies.- 7. Immunotolerance as a Mechanism of Resistance to Targeted Therapies in Melanoma.- 8. Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer.- 9. Targeting DNA repair.- 10.Resistance to Hormonal Therapy in Prostate Cancer.- 11. Mechanism of Resistance in Gastrointestinal Stromal Tumors.- 12. Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia.- 13. Mechanisms of Resistance to Targeted Therapies in Chronic Myeloid Leukemia.- 14. Mechanisms of Resistance in Multiple Myeloma.- 15. Cancer Evolution as the New Frontier of Precision.

Erscheinungsdatum	25.01.2019
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	VIII, 297 p. 32 illus., 31 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	625 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	antibacterial drug resistance • Chemotherapy • Drug mechanisms • drug resistance • immunotherapy • targeted therapy
ISBN-10	3-030-10506-7 / 3030105067
ISBN-13	978-3-030-10506-8 / 9783030105068
Zustand	Neuware