Antitumor Drug Radiation Interactions

Bridget T. Hill, Angela S. Bellamy (Herausgeber)

Buch | Hardcover

294 Seiten

2017
CRC Press (Verlag)
978-1-315-89061-6 (ISBN)

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This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations. It includes discussions on the relative merits of experimental data derived from animal versus human tumors. This book also presents a section on the potential for new model systems or alternative test procedures for evaluating therapeutic benefits and cytotoxicities. Results of randomized clinical studies are reviewed with emphasis on recent studies involving protocols specifically designed to test the benefits from optimal integration of chemotherapy with radiotherapy. This book is intended for laboratory researchers in the field and clinicians interested in using the combined modality approach. It is also a useful resource for radiologists, oncologists, and all those interested in cancer research.

Bridget T. Hill, Ph.D., is Head of the Cellular Chemotherapy Laboratory at the Imperial Cancer Research Fund Laboratories in London, England and is an Honorary Senior Lecturer at the Institute of Urology, University College and Middlesex School of Medicine of University College London. Angela S. Bellamy, M. A.(Cantab.), Ph.D., is now the Product Development Manager for Gower Medical Publishing, London, England.

Fundamental Concepts Associated with Combining Cytotoxic Drugs and X-Irradiation. Radiation Damage Interaction with Actinomycin D and Adriamycin. Interactions between Bleomycin and X-Irradiation. Interactions between Cyclophosphamide and Radiation. Useful Interactions between 5-Fluorouracil and Radiation in Man: 5-Fluorouracil as a Radio-Sensitizer. Interactions between Microtubule Inhibitors and Ionizing Radiation. Interactions between Mitomycin C and Radiation. Interactions between Nitrosoureas and X-Irradiation. Interactions between Cisplatin and Radiation in Experimental Rodent Tumors and Normal Tissues. Interactions between Platinum Coordination Complexes and Radiation. Experimental Drug-Radiation Interactions in Critical Normal Tissues. In Vitro Drug-Radiation Interactions Using Fractionated X-Irradiation Regimens. Overview of Experimental Investigations of Interactions between Antitumor Drugs and X-Irradiation. Clinical Role of Combined Chemotherapy and Radiotherapy. Overview of Recent Developments and Perspectives.

Erscheinungsdatum	16.01.2018
Verlagsort	London
Sprache	englisch
Maße	178 x 254 mm
Gewicht	700 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
ISBN-10	1-315-89061-5 / 1315890615
ISBN-13	978-1-315-89061-6 / 9781315890616
Zustand	Neuware