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Biomedical Applications of Functionalized Nanomaterials

Concepts, Development and Clinical Translation

Bruno Sarmento, Jose das Neves (Herausgeber)

Buch | Softcover

778 Seiten

2018
Elsevier - Health Sciences Division (Verlag)
978-0-323-50878-0 (ISBN)

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Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine.

This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.

BBruno Sarmento is Principal Investigator and Group Leader at Institute for Research and Innovation in Health (i3S), University of Porto (UP), and Invited Associate Professor at Instituto Universitário de Ciências da Saúde (IUCS), Portugal. His research is focused on the development of mucosal tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He has also established functionalized nanomedicines for mucosal drug delivery of drug with poor mucosal bioavailability. He published more than 400 papers in international journals, most in top journals (20000 Scopus citations; H-index 73). He edited 5 books, participated in more than 50 invited/selected talks in national and international meetings and was awarded several distinctions. He has supervised/co-supervised 15 Post-Docs, 50 PhD students and 40 MSc students. He is editor of European Journal of Pharmaceutical Sciences, and member of the Editorial Advisory Board of several international journals, including the Journal of Controlled Release, Expert Opinion on Drug Delivery and Pharmaceutics. Bruno Sarmento was the first Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society (CRS) and is now Director-at-Large of CRS and member of CRS College of Fellows. José das Neves is a Post-Doctoral Researcher at INEB, the Instituto de Engenharia Biomédica, Porto, Portugal. His research interests focuses on vaginal drug delivery, nanotechnology-based drug carriers and biomaterials. He has previously written 7 book chapters and is the co-editor of three books.

Introduction: From the "magic bullet" to advanced nanomaterials: An historical perspective

Part I. Ligand selection and functionalization of nanomaterials1. Phage display technology for screening antibody fragments2. Bioengineered approaches for site-orientation of peptide-based ligands of nanomaterials3. Engineered protein variants for bioconjugation4. Engineering of nanozymes for biomedical applications5. Strategies for the functionalization of mesoporous nanomaterials for biomedical use6. Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer selection7. Biological methodologies for assessment of functionality of nanomaterials

Part II. Specific applications of functionalized nanomaterials in therapy and diagnostics8. Functionalized graphene-based materials for bioimaging applications9. Multifunctional magnetic nanoparticles for theranostic applications10. Stimuli-sensitive grafting polymers for targeted anticancer drug delivery 11. Functional moieties for intracellular traffic of nanomaterials12. Biofunctionalized mesoporous silica nanomaterials for nuclei targeting13. Lipid-derived nanoparticles for targeted delivery of siRNA14. Aptamer-siRNA nanoparticles for targeted anti-HIV therapeutics15. Peptide and protein self-assembled nanofibers for vaccine development and immunotherapy16. Functional biomaterials for vascular tissue engineering17. Functionalized hydrogels for culture and delivery of cells

Part III. Manufacturing, regulatory challenges and clinical testing of functionalized nanomaterial-based products18. Manufacturing and safety guidelines for the manufactured functional nanomaterials19. Challenges for planning clinical trials of functionalized nanomaterials20. Clinical testing of ACCURINS® therapeutics: challenges and lessons learned

Erscheinungsdatum	31.03.2018
Reihe/Serie	Micro & Nano Technologies
Verlagsort	Philadelphia
Sprache	englisch
Maße	191 x 235 mm
Gewicht	450 g
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Technik ► Maschinenbau
	Technik ► Medizintechnik
ISBN-10	0-323-50878-2 / 0323508782
ISBN-13	978-0-323-50878-0 / 9780323508780
Zustand	Neuware