Design,Synthesis& Pharmacological Screening of Some Novel Heterocycles

Anna Pratima Nikalje, Mangesh Ghodke (Autoren)

Buch | Softcover

408 Seiten

2017
Scholar's Press (Verlag)
978-3-330-65127-2 (ISBN)

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Synthesis of nitrogen and sulphur heterocycles is of current interest because of their broad spectrum biological activities.The heterocycles such as 1,5-benzothiazepine, indole, azetidinone have gained attention of medicinal chemists due to their use as drugs and medicaments in a large number of diseases. The thesis work reports design and synthesis of these mentioned pharmacologically active heterocycles and coupled heterocycles bearing appropriate pharmacophores needed for anti convulsant, CNS depressant and antifungal actvities. The aromatic rings , heterocyclic substituents and one / two heterocyclic moities are coupled and developed via the necessary pharmacophoric groups, required for the respective activity. The combination of two heterocyclic moities is done with the hope of obtaining more potent and efficient derivatives giving synergistic, enhanced pharmacological activity.The green chemistry tools such as Microwave, Ultrsound synthesizer, solvent-free reactions are used so as to avoid pollution of surroundings. Eco-friendly, neat clean synthetic strategies and protocols are planned in such a way to avoid chemical wastage and maintain pollution-free surroundings

Dr. Anna Pratima Nikalje, Prof.& Head,Department of PharmaceuticalChemistry, Y.B. Chavan College of Pharmacy,Dr. Rafiq ZakariaCampus, Aurangabad, MS, India she has 27 Years Teaching & Research Experience and is Ph.D.Guide.She has published 97 high impact research papers Dr. Mangesh Ghodke M.Pharm,Ph.D.& teaching Medicinal Chemistry since 14 Yrs.

Erscheinungsdatum	03.05.2017
Sprache	englisch
Maße	150 x 220 mm
Gewicht	624 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	antibacterial • Anticonvulsant • Antifungal • CNS depressant • Dockingstudies • Nitrogen -Sulphur Heterocycles • Pharmazie
ISBN-10	3-330-65127-X / 333065127X
ISBN-13	978-3-330-65127-2 / 9783330651272
Zustand	Neuware