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Practical Hemostasis and Thrombosis (eBook)

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2016 | 3. Auflage
John Wiley & Sons (Verlag)
9781118344750 (ISBN)

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Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders.
  • Provides essential practical management for all those working in the field of hemostasis and thrombosis 
  • Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies
  • Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders
  • Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading
  • Highlights controversial issues and provides advice for everyday questions encountered in the clinic


Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA 

Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UK

David Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada


Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic

Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UK David Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada

List of Contributors ix

1 Basic Principles Underlying Coagulation 1
Dougald M. Monroe

2 Laboratory Tests of Hemostasis 12
Steve Kitchen and Michael Makris

3 Molecular Diagnostic Approaches to Hemostasis 27
Paula James and David Lillicrap

4 Tests of Platelet Function 42
Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison

5 Evaluation of the Bleeding Patient 63
Alice Ma and Marshall Mazepa

6 Hemophilia A and B 79
Rhona M. Maclean and Michael Makris

7 Von Willebrand disease 94
Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero

8 The Rarer Inherited Coagulation Disorders 113
Paula H.B. Bolton-Maggs, Jonathan Wilde and Gillian N. Pike

9 Acquired Inhibitors of Coagulation 124
Riitta Lassila and Elina Armstrong

10 Quantitative Platelet Disorders 134
Riten Kumar and Walter H.A. Kahr

11 Qualitative Platelet Disorders 160
Eti A. Femia Gian Marco Podda and Marco Cattaneo

12 Disseminated Intravascular Coagulation 172
Raj S. Kasthuri and Nigel S. Key

13 Thrombotic Microangiopathies 183
Marie Scully and David Kavanagh

14 Venous Thromboembolism 195
Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon

15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210
Brandi Reeves and Stephan Moll

16 Arterial Thrombosis 229
R. Campbell Tait and Catherine N. Bagot

17 Anticoagulation: Heparins and Vitamin K Antagonists 240
Gualtiero Palareti and Benilde Cosmi

18 The Direct Oral Anticoagulants 253
David A. Garcia, Mark A. Crowther and Walter Ageno

19 Antiphospholipid Syndrome 269
Henry G. Watson and Mark Crowther

20 Cardiovascular Medicine 282
Sreekanth Vemulapalli and Richard C. Becker

21 Cardiothoracic Surgery 299
Denise O'Shaughnessy and Ravi Gill

22 Neurology 314
Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang

23 Hepatology 329
Lara N. Roberts, Raj K. Patel and Roopen Arya

24 Nephrology 340
Vimal K. Derebail and Thomas L. Ortel

25 Oncology 355
Anna Falanga and Marina Marchetti

26 Obstetrics, Contraception, and Estrogen Replacement 379
Amy Webster and Sue Pavord

27 Pediatrics 393
Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte

28 Intensive and Critical Care 414
Beverley J. Hunt

29 Transfusion 433
Adrian Copplestone

Appendix 1 Reference Ranges 444
Steve Kitchen and Michael Makris

Index 452

"I would heartily recommend this attractively presented book to every coagulation laboratory and every haematologist." (Royal College of Pathologists, 1 April 2011)

List of Contributors


  1. Walter Ageno, MD
  2. University of Insubria
  3. Varese
  4. Italy
  1. Elina Armstrong, MD
  2. Coagulation Disorders Unit, Department of Hematology, Comprehensive Cancer Center
  3. Helsinki University Hospital
  4. Helsinki
  5. Finland
  1. Roopen Arya, MA PhD FRCP FRCPath
  2. Thrombosis and Haemostasis
  3. Department of Haematological Medicine
  4. King's College Hosptial
  5. London
  6. UK
  1. Natalie Aucutt-Walter, MD
  2. Division of Vascular Neurology
  3. Department of Neurology
  4. Penn State Milton S. Hershey Medical Center
  5. Hershey, PA
  1. Catherine N. Bagot, MBBS MD FRCPath
  2. Department of Haematology
  3. Royal Infirmary
  4. Glasgow
  5. UK
  1. Mary Bauman, RN MN NP
  2. Stollery Children’s Hospital
  3. University of Alberta Edmonton
  4. Canada
  1. Richard C. Becker, MD
  2. Division of Cardiovascular Health and Disease
  3. University of Cincinnati College of Medicine
  4. Cincinnati
  5. Ohio
  6. USA
  1. Paula HB Bolton-Maggs, DM FRCP FRCPath
  2. Serious Hazards of Transfusion Office
  3. Manchester Blood Centre, Plymouth Grove
  4. Manchester
  5. UK
  1. Aisha Bruce, MD
  2. University of Alberta
  3. Medical Director Pediatric Hematology
  4. Stollery Children’s Hospital
  5. Edmonton
  6. Canada
  1. G. Castaman, MD
  2. Center for Bleeding Disorders and Coagulation
  3. Department of oncology
  4. Careggi University Hospital
  5. Florence
  6. Italy
  1. Marco Cattaneo, MD
  2. Medicina III, Ospedale San Paolo
  3. ASST Santi Paolo e Carlo
  4. Dipartimento di Scienze della Salute
  5. Università degli Studi di Milano
  6. Milano, Italy
  1. Adrian Copplestone, MB BS
  2. Plymouth University Peninsula School of Medicine
  3. UK
  1. B.Cosmi, MD PhD
  2. Dept Angiology and Blood Coagulation
  3. Department of Experimental, Diagnostic and Specialty Medicine
  4. S.Orsola-Malpighi University Hospital
  5. Bologna, Italy
  1. Mark Crowther, BSc (Med Sci) MBChB MSc MRCP FRCPath
  2. Department of Haematology
  3. Worcestershire Royal Hospital
  4. Worcester
  5. England, UK
  1. Mark A. Crowther, MD
  2. McMaster University
  3. Hamilton
  4. Canada
  1. Vimal K. Derebail, MD MPH
  2. UNC Kidney Center
  3. Division of Nephrology and Hypertension Department of Medicine
  4. University of North Carolina
  5. North Carolina, USA
  1. Anna Falanga, MD
  2. Department Immunohematology and Transfusion Medicine
  3. Hospital Papa Giovanni XXIII
  4. Bergamo
  5. Italy
  1. Eti Alessandra Femia, PhD
  2. Medicina 3, Ospedale San Paolo Dipartimento di Scienze della Salute
  3. Università degli Studi di Milano
  4. Milan
  5. Italy
  1. David A. Garcia, MD
  2. Medicine/Hematology
  3. University of Washington Medical Center
  4. Seattle
  5. USA
  1. Ravi Gill, BM
  2. Southampton University Hospitals Trust Tremona Road
  3. Southampton
  4. UK
  1. Dr. Paul Harrison, BSc PhD FRCPath
  2. Healing Foundation
  3. Institute of Inflammation and Ageing (IIA)
  4. University of Birmingham Laboratories
  5. New Queen Elizabeth Hospital
  6. Birmingham
  7. UK
  1. David Y. Huang, MD PhD
  2. UNC Health Care Comprehensive Stroke Center
  3. Division of Stroke and Vascular Neurology
  4. Department of Neurology
  5. University of North Carolina
  6. North Carolina
  7. USA
  1. Beverley J. Hunt, MB ChB FRCP FRCPath MD
  2. Thrombosis & Haemostasis, King’s College
  3. Departments of Haematology & Pathology Guy’s & St Thomas’ NHS Foundation Trust & Viapath
  4. London, UK
  1. Dr. Paula James, DM FRCP FRCPath
  2. Department of Medicine
  3. Queen’s University
  4. Kingston
  5. Canada
  1. Valerie L. Jewells, DO FACR
  2. Department of Radiology
  3. University of North Carolina at Chapel Hill
  4. Chapel Hill
  5. North Carolina, USA
  1. Walter H.A. Kahr, MD PhD FRCPC
  2. Departments of Pediatrics and Biochemistry University of Toronto
  3. Division of Hematology/Oncology and Program in Cell Biology
  4. The Hospital for Sick Children
  5. Toronto
  6. Canada
  1. Raj S. Kasthuri, MB BS
  2. Division of Hematology and Oncology
  3. University of North Carolina
  4. Chapel Hill
  5. North Carolina, USA
  1. David Kavanagh, MB ChB PhD
  2. Institute of Genetic Medicine
  3. Newcastle University
  4. Newcastle upon Tyne
  5. UK
  1. Clive Kearon, MB MRCPI FRCPC PhD
  2. Department of Medicine
  3. Division of Hematology & Thromboembolism
  4. McMaster University
  5. Hamilton, Ontario
  6. Canada
  1. Nigel S. Key, MB ChB FRCP
  2. Division of Hematology and Oncology
  3. University of North Carolina
  4. Chapel Hill, North Carolina
  5. USA
  1. Steve Kitchen, PhD
  2. Sheffield Haemophilia and Thrombosis Centre
  3. Royal Hallamshire Hospital
  4. Sheffield
  5. UK
  1. Riten Kumar, MD MSc
  2. The Ohio State University
  3. The Joan Fellowship in Pediatric Hemostasis-Thrombosis
  4. Division of Hematology/Oncology/BMT
  5. Nationwide Children’s Hospital
  6. Columbus, USA
  1. Sarah Takach Lapner, MD MSc FRCPC
  2. Department of Medicine Division of Hematology
  3. University of Alberta
  4. Edmonton, Alberta
  5. Canada
  1. Riitta Lassila, MD PhD
  2. University of Helsinki
  3. Haemophilia Center
  4. Department of Hematology
  5. Comprehensive Cancer Center
  6. Helsinki University Hospital
  7. Helsinki
  8. Finland
  1. Dr. David Lillicrap, MD FRCPC
  2. Department of Pathology and Molecular Medicine
  3. Richardson Laboratory
  4. Queen’s University
  5. Kingston
  6. Canada
  1. Lori-Ann Linkins, MD MSc(Clin Epi) FRCPC
  2. Department of Medicine
  3. Division of Hematology & Thromboembolism
  4. McMaster University
  5. Hamilton, Ontario
  6. Canada
  1. Marie Lordkipanidzé, BPharm PhD
  2. Université de Montréal & Research center
  3. Montreal Heart Institute
  4. Canada
  1. Gillian C. Lowe, MRCP FRCPath PhD
  2. University Hospital Birmingham NHS Foundation Trust and College of Medical and Dental Sciences
  3. University of Birmingham
  4. UK
  1. Alice Ma, MD
  2. University of North Carolina
  3. Chapel Hill, North Carolina
  4. USA
  1. Rhona M. Maclean, MB ChB
  2. Sheffield Haemophilia and Thrombosis Centre
  3. Royal Hallamshire Hospital
  4. Sheffield
  5. UK
  1. Mike Makris, MD
  2. Sheffield Haemophilia and Thrombosis Centre
  3. Royal Hallamshire Hospital
  4. Sheffield
  5. UK
  1. Marina Marchetti, PhD
  2. Department Immunohematology and Transfusion Medicine
  3. Hospital Papa Giovanni XXIII
  4. Bergamo
  5. Italy
  1. M. Patricia Massicotte, MD MSc
  2. Director KIDCLOT Program
  3. University of Alberta
  4. Stollery Children’s Hospital
  5. Edmonton
  6. Canada
  1. Marshall Mazepa, MD
  2. Department of Pathology and Laboratory Medicine
  3. University of North Carolina
  4. Chapel Hill, North Carolina
  5. USA
  1. Stephan Moll, MD
  2. University of North Carolina School of Medicine
  3. Department of Medicine, Division of Hematology-Oncology
  4. Chapel Hill, North Carolina
  5. USA
  1. Dougald M. Monroe, PhD
  2. Division of Hematology/Oncology School of Medicine
  3. University of North Carolina
  4. North Carolina
  5. USA
  1. Denise O'Shaughnessy, DPhil
  2. Southampton University Hospitals Trust
  3. Tremona Road
  4. Southampton
  5. UK
  1. Thomas L. Ortel, MD PhD
  2. Division of Hematology Department of Medicine
  3. Duke University
  4. North Carolina
  5. USA
  1. Gualtiero Palareti, MD
  2. Cardiovascular Diseases
  3. University of Bologna
  4. Italy
  1. Raj K. Patel, MD FRCP FRCPath
  2. Department of Haematological Medicine
  3. King's College...

Erscheint lt. Verlag 29.11.2016
Sprache englisch
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Schlagworte anticoagulation using vitamin K antagonists and direct oral anticoagulants • Antiphospholipid Syndrome • arterial thrombosis • Bleeding • coagulation • coagulation inhibitors • David Lillicrap • DVT • Hämatologie • Hämatologie • Hematology • Hemophilia • Hemostasis • Heparin • inherited coagulation disorders • Medical Science • Medizin • Michael Makris • myeloproliferative neoplasms • Nigel S. Key • platelet disorders • Platelet function • Practical Hemostasis and Thrombosis • Thrombose u. Hämostase • Thrombose u. Hämostase • thrombosis • Thrombosis & Hemostasis • thrombotic microangiopathies • Transfusion Medicine • Venous Thromboembolism • Von Willebrand disease • VTE
ISBN-13 9781118344750 / 9781118344750
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