Stem Cells in Toxicology and Medicine (eBook)

Saura C. Sahu (Herausgeber)

eBook Download: EPUB

2016
John Wiley & Sons (Verlag)
978-1-119-13543-2 (ISBN)

Infos

A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine

• Presented by internationally recognized investigators in this exciting field of scientific research
• Provides an insight into the current trends and future directions of research in this rapidly developing new field
• A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government 

Autor

Dr. Saura C. Sahu Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of "Hepatotoxicity" (Wiley, 2007), "Toxicogenomics" (Wiley, 2008), "Nanotoxicity" (Wiley, 2009), and "Handbook of Systems Toxicology" (Wiley, 2011).

Inhalt

List of contributors

Preface

Acknowledgements

PART I

1. Introduction
Sara C. Sahu

2. Application of Stem cells and iPS cells in Toxicology
Maria Virginia Caballero, Ramon Espinoza Lewis and Manila Candiracci

3. Stem cells: A potential source for high throughput screening in toxicology
Harish K Handral, Gopu Sriram and Tong Cao

4. Human pluripotent stem cells for toxicological screening
Du Lili and Chen Dunjin

5. Effects of culture conditions on maturation of stem cell-derived cardiomyocytes
Deborah K. Hansen, Amy L. Inselman and Xi Yang

6. Human stem cell-derived cardiomyocyte in vitro models for cardiotoxicity screening
Tracy Walker, Kate Harris, Evie Maifoshie, Khuram Chaudhary

7. Disease-Specific Stem Cell Models for Toxicological Screenings and Drug Development
Matthias Jung, Juliane-Susanne Jung, Jovita Schiller and Insa S. Schroeder

8. Three-dimensional culture systems and humanized liver models using hepatic stem cells for enhanced toxicity assessment
Ran-Ran Zhang, Yun-Wen Zheng, Hideki Taniguch)

9. Utilization of in vitro neurotoxicity models in pre-clinical toxicity assessment
Karin Staflin, Dinah Misner, and Donna Dambach

10. A human stem cell model for creating placental syncytiotrophoblast, the major cellular barrier that limits fetal exposure to xenobiotics
R. Michael Roberts, Shinichiro Yabe, Ying Yang, and Toshihiko Ezashi

11. Effects of Endocrine Disruptors on Mesenchymal Stem Cells
Marjorie Bateman, Amy Strong, John McLachlan, Matthew Burow, Bruce Bunnell

12. Epigenetic Landscape in Embryonic Stem Cells
Xiaonan Sun, Nicholas Spellmon, Joshua Holcomb, Wen Xue, Chunying Li and Zhe Yang

PART II

13. The Effect of Human Pluripotent Stem Cell Platforms on Preclinical Drug Development
Kevin G. Chen

14. Generation and application of 3D culture systems in human drug discovery and medicine
Rashidi H and Hay DC

15. Characterization and therapeutic uses of adult mesenchymal stem cells
Julian Kiang

16. Stem Cell Therapeutics for Cardiovascular Diseases
Yuning Hou, Xiaoqing Guan, Shukkur M. Farooq, Xiaonan Sun, Peijun Wang, Zhe Yang, and Chunying Li

17. Stem cell-based therapies for vascular regeneration in peripheral artery diseases
David Smadia and Jean-Sebastien Silvestre

18. Gene modified stem/progenitor cell therapy for ischemic stroke
Yaning Li, Guo-Yuan Yang, and Yongting Wang

19. Role of stem cells in the gastrointestinal tract and in the development of cancer
Pengyu Huang, Bin Li, Yun-Wen Zheng)

20. Cancer stem cells: Concept, significance and management
Haseeb Zubair, Shafquat Azim, Sanjeev Srivastava, Arun Bhardwaj, Saravanakumar Marimuthu, Mary Patton, Seema Singh, Ajay Singh

21. Stem cell signaling in the heterogenous development of medulloblastoma
Joanna Triscott and Sandra Dunn

22. Induced pluripotent stem cell-derived ocular blood-retinal barrier for disease modeling and drug discovery
Jun Jeon, Nathan Hotaling, Kapil Bharti

23. Important considerations in the therapeutic application of stem cells in bone healing and regeneration
Hoda Elkhenany, Shawn Bourdo, Alexandru Biris, David Anderson and Madhu Dhar

24. Stem cells from human dental tissue for regenerative medicine
Junjun Liu and Shangfeng Liu

25. Stem cells in the skin
Hongwei Wang, Zhonglan Su, Shiyu Song, Ting Su , Mengyuan Niu, Yaqi Sun, Hui Xu

Index

Textauszug

List of Contributors

David Anderson, Tissue Regeneration Laboratory, Department of Large Animal Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA

Shafquat Azim, Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

Marjorie Bateman, Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, USA

Arun Bhardwaj, Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

Kapil Bharti, Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD, USA

Alexandru Biris, Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AK, USA

Shawn Bourdo, Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AK, USA

Bruce A. Bunnell, Center for Stem Cell Research and Regenerative Medicine; and Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA

Matthew E. Burow, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA

Maria Virginia Caballero, Biobide‐BBD BioPhenix S.L. Mikeletegi Pasealekua, Donostia, Gipuzkoa, Spain

Manila Candiracci, Department of Biomolecular Sciences, University of Urbino “Carlo Bo,” Urbino, Italy

Kevin G. Chen, NIH Stem Cell Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA and Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA

Tong Cao, Oral Sciences Disciplines, Faculty of Dentistry, & Tissue Engineering Program, Life Sciences Institute, National University of Singapore, and NUS Graduate School for Integrative Science and Engineering, Singapore

Khuram Chaudhary, Safety Pharmacology, Mechanistic Safety and Deposition, GlaxoSmithKline, King of Prussia, PA, USA

Donna Dambach, Safety Assessment, Genentech, South San Francisco, CA, USA

Madhu Dhar, Tissue Regeneration Laboratory, Department of Large Animal Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA

Dunjin Chen, The Third Affiliated Hospital of Guangzhou Medical University, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou, P.R. China

Lili Du, The Third Affiliated Hospital of Guangzhou Medical University, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou, P.R. China

Sandra E. Dunn, Phoenix Molecular Designs, Vancouver, BC, Canada

Hoda Elkhenany, Tissue Regeneration Laboratory, Department of Large Animal Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA; and Department of Surgery, Faculty of Veterinary Medicine, Alexandria University, Egypt

Ramon A. Espinoza‐Lewis, Synthetic Genomics Inc., San Diego, CA, USA

Toshihiko Ezashi, Division of Animal Sciences and Bond Life Sciences Center, University of Missouri, Columbia, MO, USA

Shukkur M. Farooq, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Xiaoqing Guan, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Harish K Handral, Oral Sciences Disciplines, Faculty of Dentistry, National University of Singapore, Singapore

Deborah K. Hansen, Division of Systems Biology, FDA/National Center for Toxicological Research, Jefferson, AR, USA

Kate Harris, Safety Pharmacology, Mechanistic Safety and Deposition, GlaxoSmithKline David Jack Centre for Research and Development, Ware, Herts, UK

D.C. Hay, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK

Joshua Holcomb, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Nathan Hotaling, Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD, USA

Yuning Hou, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Pengyu Huang, School of Life Science and Technology, ShanghaiTech University, Shanghai, P.R. China

Amy L. Inselman, Division of Systems Biology, FDA/National Center for Toxicological Research, Jefferson, AR, USA

Jun Jeon, Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD, USA

Juliane‐Susanne Jung, Department of Anatomy and Cell Biology, Martin Luther University Halle‐Wittenberg, Halle/Saale, Germany

Matthias Jung, Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Martin Luther University Halle‐Wittenberg, Halle/Saale, Germany

Juliann G. Kiang, Radiation Combined Injury Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Department of Pharmacology and Molecular Therapeutics; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Bin Li, Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA

Chunying Li, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Yaning Li, Neuroscience and Neuroengineering Research Center, Med‐X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China

Junjun Liu, Department of Ophthalmology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, P.R. China; and Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, P.R. China

Shangfeng Liu, Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, P.R. China

Evie Maifoshie, Screening Profiling and Mechanistic Biology, NCE Molecular Discovery, GlaxoSmithKline Medicines Research Centre, Stevenage, Herts, UK

Saravanakumar Marimuthu, Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

John McLachlan, Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA

Dinah Misner, Safety Assessment, Genentech, South San Francisco, CA, USA

Mengyuan Niu, Medical School of Nanjing University, Nanjing, P.R. China

Mary C. Patton, Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

H. Rashidi, MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK

R. Michael Roberts, Division of Animal Sciences and Bond Life Sciences Center, University of Missouri, Columbia, MO, USA

Saura C. Sahu, Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA

Jovita Schiller, Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Martin Luther University Halle‐Wittenberg, Halle/Saale, Germany

Insa S. Schroeder, Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany

Jean‐Sébastien Silvestre, INSERM UMRS 970, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

Ajay P. Singh, Department of Oncologic Sciences, Mitchell Cancer Institute; and Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, USA

Seema Singh, Department of Oncologic Sciences, Mitchell Cancer Institute; and Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, USA

David M Smadja, INSERM UMRS 1140, Université Paris Descartes, Sorbonne Paris Cité; and AP‐HP, Hôpital Européen Georges Pompidou, Service d’hématologie Biologique, Paris, France

Nicholas Spellmon, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Shiyu Song, Medical School of Nanjing University, Nanjing, P.R. China

Gopu Sriram, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore

Sanjeev K Srivastava, Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

Karin Staflin, Safety Assessment, Genentech, South San Francisco, CA, USA

Amy L. Strong, Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, USA

Ting Su, Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China

Zhonglan Su, Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China

Xiaonan Sun, Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA

Yaqi Sun, Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R....

Produkt-Details

• Erscheint lt. Verlag: 13.10.2016
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik
• Schlagworte: Alzheimer's • Biowissenschaften • Cell & Molecular Biology • Cell Biology • Chemie • Chemistry • Life Sciences • Medical Science • Medizin • neurodegenerative diseases • Parkinson's Disease • Stammzelle • Stem Cells • Toxicology • Toxikologie • Zellbiologie • Zell- u. Molekularbiologie
• ISBN-10: 1-119-13543-5 / 1119135435
• ISBN-13: 978-1-119-13543-2 / 9781119135432