Neurotransmitters and Drugs
Chapman and Hall (Verlag)
978-0-412-36100-5 (ISBN)
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An understanding of the manner in which therapeutically used drugs modify the nervous system requires knowledge of the functions, distribution and control of neurotransmitters. This textbook provides an introduction to the main neurotransmitter substances in the body, their association with clinical states and the interaction of therapeutically used drugs within these systems. Each chapter is devoted to a specific neurotransmitter substance, and examines their synthesis, storage, release, receptor interaction and inactivating mechanisms, together with important drugs known to interact selectively with these various mechanisms. The treatment of relevant disorders, such as Parkinson's disease and schizophrenia, as well as side effects are discussed. This third edition has been rewritten to reflect recent advances in the field and to incorporate up-to-date references. In particular new material on the structure and function of receptors and on amino acids has been incorporated.
Nevertheless, the book retains its compact style and, in covering all pharmacological aspects of neurotransmission in both the peripheral and central nervous systems, should continue to provide students of medicine, pharmacology, pharmacy and postgraduate psychiatry with a useful reference source.
Part 1 Neurotransmission - sites at which drugs modify neurotransmission: the neurone; axonal transport; neuronal cell membranes; precursors; synthesis; storage; organelles and enzymes; release; receptors; inactivation; neurotransmitters and neuromodulators; neurotransmitters in the nervous system; neurotransmitters and drugs. Part 2 Acetylcholine: synthesis; storage; release; cholinergic receptors; inactivation of acetylcholine; therapeutic uses and consequences of drugs acting at cholynergic synapsis; Part 3 Noradrenaline: synthesis; storage; release; adrenoceptors; inactivation of noradrenaline; therapeutic applications and consequences of drugs acting at noradrenergic synapsis. Part 4 Dopamine: synthesis; storage; release; dopamine systems; inactivation of dopamine; therapeutic applications and consequences of drug acting at dopamimergic synapsis. Part 5 5-Hydroxytryptamine: synthesis; storage; release; 5-HT receptors; inactivation of 5-HT; therapeutic applications and consequences of drugs acting at 5-HT synapsis. Part 6 Histamine: synthesis; storage; release; histamine receptors; inactivation of histamine; therapeutic applications and consequences of drug action on histamine systems; Part 7 Inhibitory amino acids - GABA, glycine and taurine: aminobutyric acid; glycine; taurine. Part 8 Escitatory amino acids - l-glutamic acid and l-aspartic acid: synthesis; storage; release; excitant amino acid receptors in the CNS; inactivation of released excitatory amino acids. Part 9 Peptides and neuronal function: peptides as neurotransmitters and hormones; synthesis, storage, transport, release and inactivation on neuropeptides; co-existence and co-transmission of peptides with classical neurotransmitters; opioid transmitters; substance P (the tachykinins); cholecystokinin (CCK); vasoactive intestinal polypeptide; neurotensin; somatostatin (ST); bombesin.
| Erscheint lt. Verlag | 13.6.1991 |
|---|---|
| Zusatzinfo | index |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 420 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie | |
| ISBN-10 | 0-412-36100-0 / 0412361000 |
| ISBN-13 | 978-0-412-36100-5 / 9780412361005 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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