Mosaicism in Human Skin

Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia

Rudolf Happle (Autor)

Buch | Softcover

XIII, 229 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2014
Springer Berlin (Verlag)
978-3-662-50205-1 (ISBN)

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This book presents an overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. It will help dermatologists understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.

Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.

PATTERNS AND MECHANISMS: Mosaicism as a Biological Concept:.- History.- Mosaicism in Plants, Animals, Humans.- Mosaicism Versus Chimerism.- The Mechanisms of Mosaicism .- Genomic Mosaicism of Autosomes.- Epigenetic Mosaicism of autosomes.- Genomic Mosaicism of X Chromosomes.- Epigenetic Mosaicism of X Chromosomes.- The patterns of Mosaicism .- Lines of Blaschko.- Checkerboard Pattern.- Phylloid Pattern.- Patchy Pattern Without Midline Separation.- Lateralization.- Other Patterns, so far Unclassifiable.- MOSAIC SKIN DISORDERS: Nevi.- Melanocytic Nevi.- Other Forms of Pigmentary Mosaicism.- Epidermal Nevi.- Vascular Nevi.- Connective Tissue Nevi.- Nevoid Skin Disorders.- Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders.- Autosomal Non-Nevi.- Neoplastic Skin Lesions.- Benign Tumors.- Malignant Tumors.- CONCLUSION.

Erscheinungsdatum	03.08.2016
Zusatzinfo	XIII, 229 p. 232 illus., 208 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
Schlagworte	Dermatology • Genetics • Human genetics • Lethal mutations • Lines of Blaschko • medical genetics • Medicine • Neurology • Neurology and clinical neurophysiology • Nevi • Ophthalmology • Paediatric medicine • Pediatrics • skin disorders
ISBN-10	3-662-50205-4 / 3662502054
ISBN-13	978-3-662-50205-1 / 9783662502051
Zustand	Neuware