NMR in Pharmaceutical Science (eBook)
John Wiley & Sons (Verlag)
978-1-118-66023-2 (ISBN)
NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists.
This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies.
Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.
NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips!Visit: www.wileyonlinelibrary.com/ref/eMagRes
Jeremy R. Everett, Ph.D., Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich, UK John C. Lindon, Ph.D., Imperial College London, UK Ian D. Wilson, Ph.D., Imperial College London, UK Robin Harris, Ph.D., Department of Chemistry, University of Durham, UK
1 Drug Discovery and Development: The Role of NMR
2 Modern NMR Pulse Sequences in Pharmaceutical R & D
3 Experimental NMR Methods for Pharmaceutical Research and Development
4 19F NMR spectroscopy: applications in pharmaceutical studies
5 Quantitative NMR Spectroscopy in Pharmaceutical R & D
6 High-throughput NMR in Pharmaceutical R & D
7 Multivariate Data Analysis methods for Pharmaceutical NMR
8 The Role of NMR in Target Identification & Validation for Pharmaceutical R & D
9 High Resolution MAS NMR of Tissues and Cells
10 NMR Studies of Inborn Errors of Metabolism.
11 NMR-Based Structure Confirmation of Hits & Leads in Pharmaceutical R & D
12 Fragment-based drug design using NMR methods
13 Hit Discovery from Natural Products in Pharmaceutical R & D
14 NMR-Based Structure Determination of Drug Leads and Candidates
15 Mixture Analysis in Pharmaceutical R & D using Hyphenated NMR Techniques
16 Conformation and Stereochemical Analysis of Drug Molecules
17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds
18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety
19 Pre-clinical Drug Metabolism using NMR
20 Pre-clinical Drug Efficacy and Safety using NMR Spectroscopy
21 Characterization of Pharmaceutical Compounds by Solid-State NMR
22 Structure-based Drug Design using NMR
23 Pharmaceutical Technology Studied by MRI
24 NMR-Based Metabolic Phenotyping for Disease Diagnosis & Stratification
25 NMR-Based Pharmacometabonomics: A New Approach to Personalised Medicine
26 Clinical MRI Studies of Drug Efficacy & Safety
27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&D
28 Analysis of counterfeit medicines and adulterated dietary supplements by NMR
29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy
30 NMR Spectroscopy in the European & US Pharmacopoeias
31 NMR in Pharmaceutical Manufacturing
Contributors
| Thomas M. Bocan | US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA The Geneva Foundation, 917 Pacific Ave, Suite 600, Tacoma, WA 98402, USA Chapter 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety |
| Sarah K. Branch | Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK Chapter 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy Chapter 30 NMR Spectroscopy in the European and US Pharmacopeias |
| Stephen J. Byard | Covance Laboratories, Alnwick, UK Chapter 23 Pharmaceutical Technology Studied by MRI |
| Leo L. Cheng | Massachusetts General Hospital, Harvard Medical School, Pathology, MGH 149, 13th Street Charlestown, Boston, MA 02129, USA Chapter 9 High-resolution MAS NMR of Tissues and Cells |
| Muireann Coen | Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK Chapter 20 Preclinical Drug Efficacy and Safety Using NMR Spectroscopy |
| Olivia Corcoran | Medicines Research Group, School of Health, Sport and Bioscience, University of East London, London E15 4LZ, UK Chapter 13 Hit Discovery from Natural Products in Pharmaceutical R&D |
| Helen Corns | Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK Chapter 30 NMR Spectroscopy in the European and US Pharmacopeias |
| Paulo Dani | Former employee from Merck Sharp & Dohme (MSD), Oss, The Netherlands Chapter 31 NMR in Pharmaceutical Manufacturing |
| Anthony C. Dona | MRC-NIHR National Phenome Centre, Department of Surgery & Cancer, Imperial College London, South Kensington Campus, London SW7 2AZ, UK Chapter 3 Experimental NMR Methods for Pharmaceutical Research and Development |
| Jeremy R. Everett | Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UK Chapter 1 Drug Discovery and Development: The Role of NMR Chapter 25 NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine |
| Paul D. Hockings | Antaros Medical, BioVenture Hub, 43183 Mölndal, Sweden Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety |
| John C. Hollerton | GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK Chapter 6 High-throughput NMR in Pharmaceutical R&D |
| Ulrike Holzgrabe | Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany Chapter 5 Quantitative NMR Spectroscopy in Pharmaceutical R&D |
| Mark Jeeves | School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK Chapter 22 Structure-based Drug Design Using NMR |
| Beatriz Jiménez | Clinical Phenotyping Centre, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK Chapter 24 NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification |
| Lauren Keith | National Institute of Allergy and Infectious Disease, 8200 Research Plaza, Frederick, MD 21702, USA Chapter 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety |
| Edwin Kellenbach | Aspen Pharmacare, PO Box 20, 5340BH Oss, Oss, The Netherlands Chapter 31 NMR in Pharmaceutical Manufacturing |
| Sarantos Kostidis | Center for Proteomics and Metabolomics, Leiden University Medical Center, P.O. Box 9600, 2300RC Leiden, The Netherlands Chapter 10 NMR Studies of Inborn Errors of Metabolism |
| John C. Lindon | Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK Chapter 4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies Chapter 15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR Techniques |
| Myriam Malet-Martino | Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France Chapter 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR |
| Robert Martino | Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 9, France Chapter 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR |
| James S. McKenzie | Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK Chapter 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research |
| Emmanuel Mikros | Faculty of Pharmacy, University of Athens Panepistimiopolis, 15771 Zografou, Greece Chapter 10 NMR Studies of Inborn Errors of Metabolism |
| Jeremy K. Nicholson | Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK Chapter 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research |
| Michael Overduin | School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK Chapter 22 Structure-based Drug Design Using NMR |
| John A. Parkinson | WestCHEM, Department of Pure and Applied Chemistry, NMR Spectroscopy Facility, University of Strathclyde, Glasgow G1 1XL, UK Chapter 2 Modern NMR Pulse Sequences in Pharmaceutical R&D |
| Torren M. Peakman | torren@nmrpeak.co.uk Chapter 14 NMR-based Structure Determination of Drug Leads and Candidates |
| Antonio Pineda-Lucena | Structural Biochemistry Laboratory, Advanced Therapies Program, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012-Valencia, Spain Chapter 12 Fragment-based Drug Design Using NMR Methods |
| Leonor Puchades-Carrasco | Structural Biochemistry Laboratory, Advanced Therapies Program, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera 3, 46012-Valencia, Spain Chapter 12 Fragment-based Drug Design Using NMR Methods |
| Lee Quill | School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK Chapter 22 Structure-based Drug Design Using NMR |
| David G. Reid | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK Chapter 23 Pharmaceutical Technology Studied by MRI Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety |
| Ricardo Riguera | Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain Chapter 17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds |
| Andrea Ruggiero | Medicines and Healthcare Products Regulatory Agency (MHRA), 151 Buckingham Palace Road, Victoria, London SW1W 9SZ, UK Chapter 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy |
| Nadeem Saeed | BioClinica, 72 Hammersmith Road, London W14 8UD, UK Chapter 26 Clinical MRI Studies of Drug Efficacy and Safety |
| Krishna Saxena | Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, D-60438, Germany German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Chapter 8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&D |
| Harald Schwalbe | Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance,... |
| Erscheint lt. Verlag | 24.8.2015 |
|---|---|
| Reihe/Serie | eMagRes Books |
| EMR Books | EMR Books |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
| Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Kernspintomographie (MRT) | |
| Naturwissenschaften ► Chemie ► Analytische Chemie | |
| Technik | |
| Schlagworte | Biochemie • biochemistry • Biowissenschaften • Chemie • Chemistry • Clinical Assessment • drug manufacturing • drug testing • Life Sciences • Magnetic Resonance • Medicine • NMR Spectroscopy / MRI / Imaging • NMR-Spektroskopie / MRT / Bildgebende Verfahren • Nuclear Magnetic Resonance • Pharmaceutical & Medicinal Chemistry • Pharmaceutical science • Pharmazeutische u. Medizinische Chemie • Toxicology |
| ISBN-10 | 1-118-66023-4 / 1118660234 |
| ISBN-13 | 978-1-118-66023-2 / 9781118660232 |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
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