Quasispecies: From Theory to Experimental Systems

Esteban Domingo, Peter Schuster (Herausgeber)

Buch | Hardcover

XIV, 357 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-23897-5 (ISBN)

Artikel merken

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Esteban Domingo is a professor at the Spanish Research Council at Centro de Biología Molecular Severo Ochoa (Madrid) and President of the Spanish Society of Virology. He is a member of EMBO and Real Academía de Ciencias Exactas, Físicas y Naturales. Peter Schuster, em. professor of University of Vienna is a member of Leopoldina, Nationale Akademie der Wissenschaften, National Academy of Sciences USA, European Academy of Sciences and Arts and several other institutions. He worked together with Manfred Eigen and developed together with him the concepts of "quasispecies" and "hypercycles".

What is a quasispecies?- Historical origins and current scope.- The nucleation of semantic information in prebiotic matter.- Evolution of RNA-based networks.- Quasispecies on fitness landscapes.- Mathematical models of quasispecies theory and exact results for the dynamics.- Theoretical Models of Generalized Quasispecies.- Theories of lethal mutagenesis: from error catastrophe to lethal defection.- Estimating fitness of viral quasispecies from next-generation sequencing data.- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models.- Cooperative Interaction within RNA Virus Mutant Spectra.- Arenavirus Quasispecies And Their Biological Implications.- Models of viral population dynamics.- Fidelity variants and RNA quasispecies.- Antiviral strategies based on lethal mutagenesis and error threshold.

Erscheint lt. Verlag	29.3.2016
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XIV, 357 p. 67 illus., 53 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Antiviral strategies • Antiviral treatments • Biomedical and Life Sciences • Drug-resistant mutants • Human genetics • immunology • Lethal mutagenesis • RNA interactions • Viral disease control • Viral disease events • Viral population dynamics • Virology • Virus spread
ISBN-10	3-319-23897-3 / 3319238973
ISBN-13	978-3-319-23897-5 / 9783319238975
Zustand	Neuware