In-Situ Gelling Polymers (eBook)

For Biomedical Applications

Xian Jun Loh (Herausgeber)

eBook Download: PDF

2014 | 2015
VIII, 226 Seiten
Springer Singapore (Verlag)
978-981-287-152-7 (ISBN)

Infos

This book presents the research involving in situ gelling polymers and can be used as a guidebook for academics, industrialists and postgraduates interested in this area. This work summaries the academic contributions from the top authorities in the field and explore the fundamental principles of in situ gelling polymeric networks, along with examples of their major applications. This book aims to provide an up-to-date resource of in situ gelling polymer research.

Inhalt

Preface 6
Contents 7
Introduction 9
1 Outlook and Perspectives 11
References 11
Introduction to In Situ Forming Hydrogels for Biomedical Applications 13
Abstract 13
1 Introduction 14
2 Chemical Hydrogels 14
3 Physical Hydrogels 15
4 Combining Chemical and Physical Crosslinking 17
5 Hydrogel Rheology 17
6 Biomedical Applications 30
7 Conclusions and Prospectives 35
References 37
Biodegradable Thermogelling Poly(Organophosphazenes) and Their Potential Biomedical Applications 44
Abstract 44
1 Introduction 44
2 Design of Biodegradable Thermogelling Poly(Organophosphazenes) 46
2.1 Synthetic Procedures 47
2.2 Thermosensitivity and Thermogelling Behaviour 51
2.3 Biodegradability and Hydrolysis Mechanism 55
3 Applications of Biodegradable Thermogelling Poly(Organophosphazenes) 57
3.1 Delivery of Antitumor Drugs 57
3.2 Human Growth Hormone Delivery 60
3.3 Long-Term Magnetic Resonance Contrast Platform 61
3.4 Gene Delivery 62
3.5 Tissue Engineering 62
4 Dual Crosslinkable Biodegradable Poly(Organophosphazenes) Thermogels 63
5 Summary 66
References 66
Designing Hydrogels by ATRP 75
Abstract 75
1 Introduction 76
2 ATRP Fundamentals 77
2.1 StructureReactivity 78
2.2 New Developments for ppm Cu 81
3 Networks and Crosslinking in ATRP 82
4 ATRP in Water and Formation of Water Soluble Polymers 85
4.1 Homogeneous Aqueous ATRP 85
4.2 ATRP in a Heterogeneous Oil–in–Water System 87
4.3 ATRP in an Inverse Water–in–Oil System 89
5 Hydrogels Prepared by ATRP 90
6 Nanogels by ATRP 92
7 In Situ Formed Hydrogels 94
8 One-Component Supersoft Gels 97
9 Conclusions 99
References 99
Supramolecular Soft Biomaterials for Biomedical Applications 112
Abstract 112
1 Introduction 112
2 Preparation of Supramolecular Hydrogels 113
2.1 Hydrogen Bonding 113
2.2 Ionic and Associative Interactions 116
2.3 Host-Guest Complexation 117
2.4 Metal-Ligand Complexation 119
2.5 Low Molecular Weight Hydrogels 121
2.6 Other Methods 125
3 Conclusion 127
References 127
Peptidic Hydrogels 131
Abstract 131
1 Primary Structures 133
2 Secondary Structures 137
3 Tertiary Structures 140
4 Quaternary Structures 141
5 Hydrogel Properties 145
References 149
Polymeric Supramolecular Hydrogels as Materials for Medicine 155
Abstract 155
1 Introduction 155
2 Hydrogels Crosslinked by Hydrogen Bonding 158
3 Hydrogels Crosslinked by Metal Complexation 165
4 Hydrogels Crosslinked by Ionic Interactions 171
5 Conclusion and Outlook 181
References 181
Hydrogels for Stem Cell Fate Control and Delivery in Regenerative Medicine 190
Abstract 190
1 Introduction 191
2 Stem Cells 192
2.1 Adult Stem Cells 192
2.2 Embryonic Stem Cells 193
3 Hydrogels 193
3.1 Natural Hydrogels 193
3.1.1 Chemical and Physical Modifications of Natural Polymers 193
3.2 Synthetic Hydrogels 195
3.2.1 Synthetic Gels Prepared by Ring-Opening Polymerization 195
3.2.2 Synthetic Gels Prepared by Radical Polymerization 195
3.2.3 Synthetic Gels Prepared by the Formation of Poly(Urethane)S 196
3.3 Composite Hydrogels and Hybrids 197
4 Hydrogel Microenvironments for Construction of Stem Cell Niche 200
4.1 Hydrogels as ECM-Mimetic 200
4.1.1 Matrix Architecture 200
4.1.2 Matrix Mechanics and Degradation 201
4.2 Growth Factors and Biomolecules 202
4.3 Support Cells 203
5 Microfabricated Hydrogels 204
6 Complexity of Tissue Environment 205
7 Advanced Hydrogel Systems for Stem Cell Delivery 206
7.1 Multi-phased Hydrogels 206
7.2 Multi-functional Hydrogels 206
8 Conclusions and Perspectives 207
References 208
From Bench to Bedside—An Example of an In Situ Hydrogel in In Vivo Applications 218
Abstract 218
1 Introduction 218
2 Non-clinical Safety and Efficacy Evaluation 220
2.1 Safety Studies 220
2.2 Tissue Distribution Studies 221
3 Development of Oncogel™ as a Potential Cancer Therapeutic Drug 221
3.1 Rat Model Studies 221
3.1.1 Spinal Cord 221
3.1.2 Glioma 222
3.2 Pig Model Studies 225
3.2.1 Pancreatic Cancer 225
3.3 Human-Clinical Trials 226
3.3.1 Esophageal Cancer 227
References 228

Produkt-Details

• Erscheint lt. Verlag: 1.10.2014
• Reihe/Serie: Series in BioEngineering
• Reihe/Serie: Series in BioEngineering
• Zusatzinfo: VIII, 226 p. 86 illus., 44 illus. in color.
• Verlagsort: Singapore
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik ► Bauwesen
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: Biodegradable Gels • Drug Release Gels • Encapsulating of Actives • In-situ Gelling Polymers • Peptide in-situ Gels • Protein Release Gels • Rheology of Hydrogels • Temperature Sensitive Polymers
• ISBN-10: 981-287-152-7 / 9812871527
• ISBN-13: 978-981-287-152-7 / 9789812871527