Inflammatory Process (eBook)

Volume 1

Lester Grant, Robert T. McCluskey, Benjamin W. Zweifach (Herausgeber)

eBook Download: PDF

2014 | 2. Auflage
670 Seiten
Elsevier Science (Verlag)
978-1-4832-2079-6 (ISBN)

Infos

The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from cell surface phenomena and connective tissue to the role of the formed elements of the blood in inflammatory states, particularly in the light of the rapidly burgeoning literature on platelet physiology. The life history and functional capacities of leukocytes are also examined, along with chemotaxis, phagocytosis, and the mechanisms responsible for tissue damage in inflammation. Comprised of 10 chapters, this volume begins with an overview of the experimental approach to the study of inflammation, followed by a discussion on the biochemistry of the mammalian plasma membrane. The reader is then introduced to cell injury; chemotaxis; phagocytosis; and lysosomal mechanisms in the inflammatory process. Subsequent chapters deal with the inflammatory process at the cellular level, paying particular attention to neutrophil leukocytes; the metabolism and physiology of mononuclear phagocytes; the role of platelets in inflammatory reactions; and structural and biochemical characteristics of mast cells. This book will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

Inhalt

Front Cover 1
The Inflammatory Process 4
Copyright Page 5
Table of Contents 6
LIST OF CONTRIBUTORS 10
PREFACE 12
PREFACE TO FIRST EDITION 14
CONTENTS OF OTHER VOLUMES 18
Part I: INFLAMMATORY PROCESS AT THE MOLECULAR LEVEL 24
Chapter 1. THE EXPERIMENTAL APPROACH TO THE STUDY OF INFLAMMATION 26
I. Introduction 27
II. The Gross Pathology of Inflammation 32
III. The Light Microscope and the Study of Inflammation 35
IV. Bacteriology and Immunology 40
V. Chemotaxis 44
VI. Phagocytosis 45
VII. The Physiological Approach to Problems of Inflammation 46
VIII. Chemical Mediators of Inflammation 60
IX. The Electron Microscope and Changes in Uitrastructure 64
X. Conclusions 66
XI. Summary 67
References 68
Chapter 2. BIOCHEMISTRY OF THE MAMMALIAN PLASMA MEMBRANE 74
I. Introduction 75
II. Morphological Background 76
III. The Chemical and Enzymatic Composition of Plasma Membranes 80
IV. Isolation of Plasma Membrane Proteins 106
V. Biosynthesis of the Plasma Membrane 110
VI. Molecular Organization of the Plasma Membrane 113
References 129
Chapter 3. CELL INJURY 138
I. Introduction 138
II. Progression of Changes in Lethal Injury 147
III. Chronic Cell Injury 159
Acknowledgments 212
References 212
Chapter 4. LYSOSOMAL MECHANISMS IN THE INFLAMMATORY PROCESS 282
I. Introduction 282
II. Formation, Classification, and Fate of Lysosomes 285
III. Structure and Contents of Lysosomes 289
IV. Functions of Lysosomes 299
V. Morphology 299
References 304
Chapter 5. CHEMOTAXIS 310
I. Introduction 310
II. Chemotaxis in Bacteria 319
III. Chemotaxis in Plants 327
IV. Chemotaxis in Lower Animal Forms 333
V. Tissue Culture Studies: Chemotactic Factors in Tumors 338
VI. Chemotaxis in White Blood Cells 339
VII. Possible Modifying Mechanisms in Chemotaxis 368
VIII. Conclusion 371
IX. Summary 374
Acknowledgments 375
References 375
Addendum 385
References 385
Chapter 6. PHAGOCYTOSIS 386
I. Introduction 386
II. General Aspects of Phagocytosis 388
III. Metabolism during Phagocytosis 396
IV. Clinical Abnormalities of Cellular Host Defense 415
Addendum 424
References 425
Part II: INFLAMMATORY PROCESS AT THE CELL LEVEL 432
Chapter 7. NEUTROPHIL LEUKOCYTES 434
I. Introduction 434
II. Terminology and Morphology 435
III. Formation, Distribution, and Fate of Neutrophils 440
IV. The Nature of Neutrophil Granules 443
V. Metabolism of Neutrophils 445
VI. Physiology of Neutrophils 446
VII. Neutrophil Functions 459
VIII. Abnormal Neutrophils 462
References 466
Chapter 8. THE METABOLISM AND PHYSIOLOGY OF THE MONONUCLEAR PHAGOCYTES 472
I. Introduction 473
II. Life History 474
III. Morphology 482
IV. Maturation 490
V. Endocytosis 498
VI. Macrophages and Host Defense 509
VII. Macrophage and the Immune Response 522
References 527
Addendum 533
Chapter 9. PLATELETS 534
I. Introduction 534
II. Reactions in Hemostasis: Effects of Thrombin, Collagen, Subendothelial Microfibrils, ADP, and Epinephrine 536
III. Reaction of Platelets with Foreign Materials 542
IV. Inhibitors of Platelet Aggregation and Release: Similarities between the Reactions of Platelets and Other Cells 555
V. Platelets in Other Inflammatory Reactions 556
References 562
Chapter 10. STRUCTURAL AND BIOCHEMICAL CHARACTERISTICS OF MAST CELLS 568
I. Introduction 568
II. Origin and Distribution of Mast Cells 569
III. Normal Tissue Mast Cells Neoplastic Mast Cells
IV. Mast Cell Cytology 573
V. Biochemistry of the Mast Cells 591
VI. Functional View of the Tissue Mast Cell 601
VII. Mast Cells in Pathological Disorders 605
VIII. Concluding Remarks 613
References 613
AUTHOR INDEX 624
SUBJECT INDEX 660

Produkt-Details

• Erscheint lt. Verlag: 12.5.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Technik ► Bauwesen
• ISBN-10: 1-4832-2079-6 / 1483220796
• ISBN-13: 978-1-4832-2079-6 / 9781483220796