Antigens (eBook)

Volume III

Michael Sela (Herausgeber)

eBook Download: PDF

2014 | 1. Auflage
640 Seiten
Elsevier Science (Verlag)
978-1-4832-6956-6 (ISBN)

Infos

The Antigens, Volume III is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining sites. Allergens and the genetics of allergy are also explored. Comprised of seven chapters, this volume begins with a review of microbial polysaccharides as antigens, followed by a discussion on antigenic determinants and their specific reaction with antibody-combining sites. The reader is then introduced to the reaction of antigens with their specific receptors on lymphocytes. The next four chapters are concerned with several categories of more complex antigens which, in most cases, have yet to be characterized adequately at a molecular level: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The book concludes with an analysis of virus infections and the immune responses they elicit. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Inhalt

Front Cover 1
The Antigens 4
Copyright Page 5
Table of Contents 8
List of Contributors 12
Preface 14
Contents of Other Volumes 16
CHAPTER 
18 
I. Introduction 18
II. Chemistry of Microbial Polysaccharide Antigens 20
III. Immunochemistry of Microbial Polysaccharide Antigens 66
IV. Immunobiology of Microbial Polysaccharide Antigens 100
V. Summary and Conclusions 125
Acknowledgments 127
References 127
CHAPTER 
144 
I. Introduction 144
II. The Structural Specificity of 
146 
III. Antigenic Determinants 150
IV. The Antibody Combining Site 170
V. Immunogenic Determinants 179
VI. Concluding Remarks 196
Acknowledgment 200
References 200
CHAPTER 
206 
I. Introduction 207
II. Historical 208
III. Two Classes of Lymphocytes 210
IV. The Lymphocyte Plasma Membrane 214
V. Relevant Properties of Immunoglobulins 218
VI. Immunoglobulins on the Lymphocyte Plasma Membrane 223
VII. The Binding of Antigen to Lymphocytes 234
VIII. Specificity and Immunocompetence of ABC 249
IX. Receptors on Lymphocytes for Antigens 259
X. Antigens, The Antigen-Receptor Complex, and Mitogens 268
XI. Inside the B Cell 274
Acknowledgments 277
References 277
CHAPTER 
288 
I. Introduction 288
II. Historical Development (1872-about 1960 291
III. Nomenclature 297
IV. Modern Allergen Research 299
V. Nature of Allergenic Sensitization and Stimulation 337
VI. Genetics of Allergy 346
VII. Practical Considerations 362
VIII. Concluding Remarks 364
Acknowledgments 367
References 367
CHAPTER 
378 
I. Introduction 379
II. History 379
III. Genetics 385
IV. Serologie Detection of H Antigens 388
V. Cell Surface Expression of H Antigens 402
VI. Cross-Reactivity of H Antigens 415
VII. Extraction, Purification, and Biologie Activity 
419 
VIII. Chemical and Molecular Nature of HL-A Antigens 435
IX. Perspectives 448
Acknowledgments 452
References 452
CHAPTER 
466 
I. Introduction 466
II. Classification and Nomenclature 467
III. Biology 468
IV. Phylogenetic Relationships 473
V. Antigenic Analysis of Mycoplasmata 476
VI. Antigenic Analysis of Chlamydiae 481
VII. Growth Inhibition and Mycoplasmacidal Activity of Serum 481
VIII. Antigenic Structure 484
References 493
CHAPTER 
496 
I. Introduction 497
II. Viral Antigens 500
III. Humoral Responses 517
IV. Secretory Antibody Responses 523
V. Thymus Dependence of Viral Antigens 524
VI. B Lymphocyte Memory and "Original Antigenic Sin" 527
VII. Neutralization 529
VIII. Capacity of Macrophages to Support Virus Replication 536
IX. Ontogeny of Macrophage Resistance to Viral Infections 539
X. Surface Changes of Virus-Infected Cells 541
XI. Evidence for Cell-Mediated Immunity to Viral Antigens 549
XII. Persistence of Immunity to Viruses 558
XIII. Tolerance to Viral Antigens 560
XIV. Cooperative Effects of Viral Antigens on Immunogenicity 563
XV. Influence of Virus Infections on Immune Responses 566
XVI. Concluding Remarks 574
References 576
Author Index 592
Subject Index 629

Produkt-Details

• Erscheint lt. Verlag: 10.5.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 1-4832-6956-6 / 1483269566
• ISBN-13: 978-1-4832-6956-6 / 9781483269566