Stereoselective Syntheses of Tetrahydropyrans (eBook)

Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A

Kiyoun Lee (Autor)

eBook Download: PDF

2014 | 2014
XIX, 184 Seiten
Springer International Publishing (Verlag)
978-3-319-04462-0 (ISBN)

Infos

In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.

Inhalt

Introduction.- Significance.- General Approaches to the Synthesis of Substituted Tetrahydropyrans.- Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions.- Introduction.- Preliminary Study.- Result and Discussion.- Synthesis of 4-Hydroxy-2,6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2′ Reaction.

Produkt-Details

• Erscheint lt. Verlag: 8.7.2014
• Reihe/Serie: Springer Theses
• Reihe/Serie: Springer Theses
• Zusatzinfo: XIX, 184 p. 256 illus., 12 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: (±)-Diospongin A • (+)-Dactylolide • (±)-Diospongin A • Gem-disubstituent Effect • (+)-Leucascandrolide A • Tandem and Organocatalytic Oxa-conjugate Addition • Tandem Cross-metathesis/thermal SN2′ • Tandem Cross-metathesis/thermal SN2′ • Tetrahydropyran
• ISBN-10: 3-319-04462-1 / 3319044621
• ISBN-13: 978-3-319-04462-0 / 9783319044620