Transition Metal Toxicity (eBook)

G. W. Richter, Kim Solez (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
206 Seiten
Elsevier Science (Verlag)
978-1-4832-1840-3 (ISBN)

Infos

International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of metal ions in biological systems; oxidative stress during the metabolic interactions of metal ions; and the actions of oxygen-derived free radicals in the pathogenesis of metal ion toxicity. The book also describes the roles played by chromium and other metals in carcinogenesis; the morphologic pathology of metal toxicosis; and metal ion overload due to inborn metabolic defects, as well as to excessive environmental exposure. Research findings at the molecular, cellular, and organ levels are reviewed. Physiologists, biochemists, pathologists, and biophysicists will find the book invaluable.

Inhalt

Front Cover 1
Transition Metal Toxicity 4
Copyright Page 5
Table of Contents 6
Contributors 8
Preface 10
Chapter 1. Iron Toxicosis 12
I. Introduction: History and Prevalence of Iron Toxicosis 13
II. Chemistry of Iron Toxicity 14
III. Pathophysiology of Iron Overload 37
IV. Treatment of Iron Overload 48
References 52
Chapter 2. Host Defenses against Copper Toxicity 58
I. Essentiality of Copper in Normal Metabolism 58
II. Balance between Essential Copper Levels and Toxicosis 59
III. Regulation of Copper Balance: Control of Homeostasis in Animals 62
IV. Copper Homeostasis in Nonanimal Cells 80
V. Conclusions 86
References 86
Chapter 3. Chromium Toxicity and Carcinogenesis 96
I. Introduction 96
II. Uptake-Reduction Model of Chromium(VI) in the Cell 100
III. Chromium(VI)-Induced DNA Damage 111
IV. Conclusion 116
References 116
Chapter 4. The Chemistry of Dioxygen Species (O2, O2–, HOO., and HOOH) and Their Activiation by Transition Metals 120
I. Introduction 120
II. Redox Chemistry of O2, O2– and HOOH 122
III. Reactivity of O2– and HOO· 123
IV. Iron-Induced Activation of HOOH 127
V. Iron-Induced Activation of Dioxygen 138
References 141
Chapter 5. Transition Metal Ions and Oxygen Radicals 144
I. Introduction 144
II. The Chemistry of Oxygen Species 146
III. The Biochemistry and Biology of Oxygen Species 150
IV. Mechanism of the Toxicity of Oxygen Radicals 152
V. The Dual Effect of Transition Metal Ions 161
VI. Defenses against Oxygen Species Derived Damage 168
References 172
Chapter 6. The Cytopathology of Metal Overload 176
I. Introduction 176
II. Iron 177
III. Copper 189
References 197
Index 200

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Technik ► Maschinenbau
• ISBN-10: 1-4832-1840-6 / 1483218406
• ISBN-13: 978-1-4832-1840-3 / 9781483218403