Control of Growth Processes by Chemical Agents (eBook)

M. Rocha E Silva, A. D. Welch (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
100 Seiten
Elsevier Science (Verlag)
978-1-4832-7916-9 (ISBN)

Infos

The Control of Growth Processes by Chemical Agents covers the proceedings of the 1966 Third International Pharmacological Meeting on Control of Growth Processes by Chemical Agents, held in Sao Paolo, Brazil. This book is composed of seven chapters, and begins with a survey of the comparative biology of dihydrofolate reductases as a basis for chemotherapy. The succeeding chapters deal with the mechanism of pyrimidine metabolism as a chemotherapeutic target and the biochemical and biological research works with arabinoforanosyl cytosine, known as cytarabine. These chapters specifically describe the cytotoxicity and antitumor activity of cytarabine. The remaining chapters discuss the advances in viral chemotherapy and the regulatory mechanisms of enzyme synthesis and their alteration in malignancy. This book will be of value to biologists, biochemists, and oncologists.

Inhalt

Untitled 1
The Control of Growth Processes by Chemical Agents 
4 
Copyright Page 
5 
Table of Contents 
6 
LIST OF AUTHORS 8
Chapter 1. INTRODUCTORY REMARKS 
10 
Chapter 2. COMPARATIVE ENZYMOLOGY OF DIHYDROFOLATE REDUCTASES AS A BASIS FOR CHEMOTHERAPY 
12 
REFERENCES 26
Chapter 3. PYRIMIDINE METABOLISM AS A TARGET FOR CHEMOTHERAPY 
28 
REFERENCES 40
Chapter 4. BIOCHEMICAL AND BIOLOGICAL STUDIES WITH ARABINOFURANOSYL CYTOSINE (CYTARABINE) 
42 
ABSTRACT 42
INTRODUCTION 43
CYTOTOXICITY STUDIES 44
ANTITUMOR STUDIES IN VIVO 49
CLINICAL INVESTIGATIONS 51
ANTIVIRAL STUDIES 53
TOXICOLOGY STUDIES 55
METABOLISM AND DISTRIBUTION STUDIES 56
MISCELLANEOUS INVESTIGATIONS 60
ACKNOWLEDGMENTS 61
REFERENCES 61
Chapter 5. RECENT ADVANCES IN VIRAL CHEMOTHERAPY 
64 
REFERENCES 73
Chapter 6. REGULATORY MECHANISMS AND THEIR ALTERATION IN MALIGNANCY 
76 
STUDIES ON THE CONTROL OF GENETIC EXPRESSION IN MAMMALIAN LIVER 
77 
STUDIES ON THE REGULATION OF ENZYME 
79 
REFERENCES 89
Chapter 7. INTEGRATING DISCUSSION AND FUTURE DIRECTIONS 
92 
ACKNOWLEDGMENT 96
INDEX 98

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik ► Bauwesen
• ISBN-10: 1-4832-7916-2 / 1483279162
• ISBN-13: 978-1-4832-7916-9 / 9781483279169