Biophysical approaches to translational control of gene expression

Buch | Softcover

320 Seiten

2014
Springer-Verlag New York Inc.
978-1-4899-8709-9 (ISBN)

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This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician. With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.

X-ray analysis of prokaryotic and eukaryotic ribosomes.- A passage through the ribosome by Cryo-EM.- Molecular dynamics simulations of the ribosome.- Structural analyses of the ribosome by chemical modification methods.- Methods for studying the interactions of translation factors with the ribosome.- Riboproteomic approaches to understanding IRES elements.- Rapid kinetic analysis of protein synthesis.- Investigating RNAs Involved in Translational Control by NMR and SAXS.- Analyses of RNA-ligand interactions by fluorescence anisotropy.- Approaches for the Identification and Characterization of RNA-Protein Interactions.- A multidisciplinary approach to RNA Localization.- Virtual Screening for RNA-interacting Small Molecules.- The ‘fifth’ RNA nucleotide: a role for ribosomal RNA pseudouridylation in control of gene expression at the translational level.- Translational Control of Synaptic Plasticity and Memory.

Reihe/Serie	Biophysics for the Life Sciences ; 1
Zusatzinfo	XII, 320 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Naturwissenschaften ► Physik / Astronomie ► Atom- / Kern- / Molekularphysik
	Naturwissenschaften ► Physik / Astronomie ► Festkörperphysik
ISBN-10	1-4899-8709-6 / 1489987096
ISBN-13	978-1-4899-8709-9 / 9781489987099
Zustand	Neuware