Biomolecular Feedback Systems (eBook)

Domitilla Del Vecchio, Richard Murray (Autoren)

eBook Download: PDF | EPUB

2014
Princeton University Press (Verlag)
978-1-4008-5050-1 (ISBN)

Infos

Domitilla Del Vecchio is associate professor of mechanical engineering at the Massachusetts Institute of Technology. Richard M. Murray is professor of control and dynamical systems and bioengineering at the California Institute of Technology. His books include Feedback Systems: An Introduction for Scientists and Engineers (Princeton).

---

This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu

Produkt-Details

• Erscheint lt. Verlag: 26.10.2014
• Zusatzinfo: 13 halftones. 113 line illus. 3 tables
• Verlagsort: Princeton
• Sprache: englisch
• Themenwelt: Mathematik / Informatik ► Mathematik ► Angewandte Mathematik
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik ► Medizintechnik
• Schlagworte: activatorвepressor clock • Addition • Allosteric regulation • Approximation • Autoregulation • Bacteria • bacterial chemotaxis • basic modeling formalisms • basic probability • Bifurcation Theory • biochemistry • biological circuits • Biological Mechanisms • biological noise • biological oscillations • Biological Systems • biomolecular feedback systems • biomolecular reactions • Biomolecular systems • Calculation • cellular resources • chemical kinetics • chemical Langevin equation • Chemical master equation • chemical reaction • Chemotaxis • chromosome • circuit behavior • Circuit Design • CLE • CME • Coding region • Computation • conservation law • Control Theory • core processes • Dephosphorylation • Derivative • design tradeoffs • deterministic models • Diagram (category theory) • differential equation • Differential Equations • Dissociation constant • Dynamical system • Dynamical Systems • Dynamical systems theory • E. coli • Eigenvalues and Eigenvectors • energy level • Engineering • engineering solutions • Enzyme • Equation • Equilibria • Equilibrium Point • Equilibrium Points • Escherichia coli • Feedback Control Theory • feedback principles • Feed forward (control) • Flagellum • FokkerАlanck equation • FPE • Frequency Response • Functionality (chemistry) • Gene circuits • gene expression • Glucose • Hill equation (biochemistry) • Hopf Bifurcation • host organism • IFFL • incoherent feedforward loop • independent circuits • inducer • Initial Condition • Input and output (medicine) • interconnecting components • Isolated system • Lac repressor • Langevin Equation • Ligand (biochemistry) • Likelihood Function • Limit cycle • limit cycles • linear differential equation • Linearization • loading effects • Lyapunov stability • Master Equation • mean behavior • Metabolism • methylation • Michaelis–Menten kinetics • Microorganism • Microstate (statistical mechanics) • modeling formalism • modular interconnection of circuits • Molecule • negative autoregulation • negative feedback • noise amplification • nonlinear system • Notation • Nullcline • nutrient • ordinary differential equation • organism • Parameter • parameter uncertainty • Phosphatase • phosphorylation • Plasmid • Post-translational modification • Prediction • Probability • Promoter (genetics) • Protease • Protein • protein A • Protein production • Quantity • Rate equation • Reaction Rate • reaction-rate equation • Regulation of gene expression • repressilator • Repressor • retroactivity attenuation • Ribosome • RNA polymerase • Robustness • Sensitivity Analysis • Sensor • signal transduction • signal transduction circuits • simple dynamical models • singular perturbation • State Space • State-space Representation • state variable • Statistical Mechanics • Step Response • stochastic behavior • Stochastic Modeling • stochastic models • Stochastic process • Stochastic Processes • Summation • Synthetic biology • synthetic circuits • systems biology • Time Scales • toggle switch • Transcription factor • Transfer Function • Uncertainty • Variable (mathematics)
• ISBN-10: 1-4008-5050-9 / 1400850509
• ISBN-13: 978-1-4008-5050-1 / 9781400850501