Hepatoprotective activity of Kamilari

Sibi P. Ittiyavirah (Autor)

Buch | Softcover

20 Seiten

2014 | 14001 A. 1. Auflage
GRIN Verlag
978-3-656-59943-2 (ISBN)

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Master's Thesis from the year 2012 in the subject Pharmacology, grade: A, Mahatma Gandhi University (University College of Pharmacy), course: M.Pharm, language: English, abstract: Polyherbal formulations available with a wide range of indications like hepatoprotective , appetite and growth promoters, gastrointestinal and hepatic regulator, as treatment for hepatic dysfunction, for hepatic regeneration as well as liver stimulant and tonic. Despite the widespread use, there is a lack of scientific evidence on their efficacy and safety. This study was designed to evaluate the effect of Polyherbal formulation Kamialri on oxidative stress and associated damages in carbon tetrachloride induced toxicity in Chang liver cells. The study is mainly focused on the evaluation of its antioxidant potential, invitro steatosis and intracellular localisation of reduced glutathione by Monochlorobimane(MCB) staining. Carbon tetrachloride induced toxicity in chang liver cells was well manifested by significant decrease in cell viability, enhanced lipid peroxidation leading to tissue damage,decreased SOD, glutathione, glutathione peroxidase and glutathione S- transferase and increased deposition of fatty acid . MTT study revealed that Kamilari has got cytoprotective activity. It has got the excellent free radical scavenging properties which was proven by various antioxidant activities (LP, SOD, GSH, GPX, and GST). Inhibitory effect of Kamilari on fatty acid deposition was proven by invitro steatosis studies which were conducted on palmitic acid treated chang cell line.Based on the above studies it is concluded that Kamilari has cytoprotective and antioxidant activity, and found to be effective in steatosis.

RESUME
Dr. SIBI P IPermanent address
Assistant professor in Pharmacy,Perumbamkudiyil house,
Department of Pharmacology, Payyappady P. O
Mahatma Gandhi University,Puthuppally,
Cheruvandoorcampus, Kottayam, Kerala.
Ettumanoor P. O
Kottayam, Kerala.
Phone: 0481-2354701 (Resi), mob: +91-9446883809
e-mail: sibitho@gmail.com
Link address: of birth: 18/03/1971 Religion: Christian Caste: Jacobite Syrian
Educational qualifications PhD in Pharmacy from Delhi University in the year February 2009. M.Pharm Specialization in Pharmacology with First Class from KLE s College of Pharmacy, Belgaum, Karnatak University, Dharwad, Karnataka in February 1996. B.Pharm from Mangalore University, Mangalore Karnataka in May 1993.
Experiences Total of 17 years and 5 months of teaching experience after M.Pharm (Pharmacology)in M.G University, Kottayam.
Publications
Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats
SS Agrawal, SP Ittiyavirah
Immunopharmacology and immunotoxicology 32 (1), 92-982
2010
Insilico docking studies and evaluation of volatile oil of Zingiber officinale Rosc. and Aripiprazole for Antidepressant activity
MP Sibi P Ittiyavirah
International Journal of Genetics and Molecular Biology, pp. 88-982013
Prospective Study of Infertility in Humans due to Life Style Changes
Sibi P Ittiyavirah,Chithra AR, Christy MS, Divya R
Indian Journal of Pharmacy Practice 6 (3), 40-422013
Evaluation of spermicidal and antiandrogenic activities of aqueous extract of Tinospora cordifolia (Willd.) stem
SP Ittiavirah, PKH Rahman
African Journal of Pharmacy and Pharmacology 7 (34), 2392-23962013
In silico docking analysis of constituents of Zingiber officinale as antidepressant
SP Ittiyavirah, M Paul
Journal of Pharmacognosy and 5 (6), 101-1052013
Studies of Cytotoxic Potential of Cucumis melo. Linn Fruit Aqueous Extract in Prostate Cancer Cell lines PC-3 Using MTT and Neutral Red Assay
SP Ittiyavirah, A George, AM Santhosh, ST Kurian, P Pappachan, G Jacob
Iranian Journal of Pharmacology & Therapeutics (IJPT) 12 (1), 24-292013
Tinosporacordifolia: A Potential Plant with Immunomodulatory Activity
SP Ittiyavirah, T Rahees
Iranian Journal of Pharmacology & Therapeutics (IJPT) 12 (1), 30-382013
Anti stress activity of Mikania micrantha kunth roots in Wistar rats
SPIS K.P
Neuro Science Behav Health, 24-272013
Nootropic Studies of Ethanolic Extract of Mimosa pudica Linn. in Albino Wistar Rats
SP Ittiyavirah, DP George
in: American Journal of Phytomedicine and Clinical Therapeutics 1, 3, 266--2752013
Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats
SP Ittiyavirah, AS Sunder
Journal of Reproductive Immunology 94 (1), 522012
ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF PLUMBAGO CAPENSIS AND PLUMBAGO INDICA
SP Ittiyavirah, KV Jobin, MS Jissa, M Jomy, TJ Josmi, B Littin
Advances In Pharmacology And Toxicology 13 (1)2012
Antiinflamatoty and analgesic effects of Plumbago capensis and Plumbago indigo
Sibi.P.Ittiyavirah, Jobin.K.V, Jisse.M.S, Johny.M
Adv. Pharmacol. Toxicol., 47-522012
Comparative evaluation of aqueous extract of some selected medicinal plants for anthelmintic activity
KTSMM SP Ittiyavirah, Jumimol TM
Int. J. Pharmacol. Bio. Sci, 25-302012
Hormonal Effects of H2 Receptor Blockers on Implantation in Albino Wistar Rats
SS Agrawal, SP Ittiyavirah
International Journal of Research in Pharmaceutical and Biomedical Science, 102011
Effect of intra-uterine injection of H-2 receptor blockers on implantation in albino Wistar rats
SS Agrawal, SP Ittiyavirah
African Journal of Pharmacy and Pharmacology 4 (10), 735-7442010

1. M.Pharm projects guided-08 in the year 2011-12.Present

Sprache	englisch
Maße	148 x 210 mm
Gewicht	44 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	hepatoprotective • kamilari
ISBN-10	3-656-59943-2 / 3656599432
ISBN-13	978-3-656-59943-2 / 9783656599432
Zustand	Neuware