Epilepsy (eBook)

John W. Miller, Howard P. Goodkin (Herausgeber)

eBook Download: EPUB

2014
John Wiley & Sons (Verlag)
978-1-118-45697-2 (ISBN)

Infos

Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help clinicians develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience.

John W. Miller, MD, PhD, University of Washington, Seattle, WA, USA

Howard P. Goodkin, MD, PhD, University of Virginia, Charlottesville, VA, USA

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Epilepsy is common but complex Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help you develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience. They provide practical guidance to: The causes and classification of epilepsy Working up seizures Antiepileptic medications Pediatric epilepsy Adult epilepsy Emergency epilepsy Comorbidity and mortality of epilepsy Clinical in approach, practical in execution, Epilepsy is packed with tricks, tips, and focused advice to help you better manage your patients seizures.

Inhalt

Contributor List ix

Series Foreword xiii

Preface xv

Part I: Epilepsy Basics

1 Recognizing Seizures and Epilepsy: Insights fromPathophysiology 3
Carl E. Stafstrom

2 Classifying Epileptic Seizures and the Epilepsies 10
Valeria M. Muro and Mary B. Connolly

3 What Causes Epilepsy? 15
Anna Rosati and Renzo Guerrini

4 Epidemiology of Seizures and Epilepsy 28
Aidan Neligan and Josemir W. Sander

Part II: Working up Seizures and Epilepsy

5 Diagnosing and Localizing Seizures at the Bedside and inClinic 35
Joseph I. Sirven

6 Psychogenic Nonepileptic Episodes 42
Vaishali S. Phatak

7 What Can the EEG Tell Us? 45
Mark Quigg

8 What Can Neuroimaging Tell Us? 54
Edward J. Novotny

9 Workup of New-Onset Seizures 61
Jennifer Langer

10 Evaluation of the Patient with Medically Refractory Epilepsy67
Gregory L. Holmes

Part III: Using Antiepileptic Medications

11 Choosing, Initiating, Adjusting, and Changing AntiepilepticMedications 77
John W. Miller

12 Antiepileptic Drug Adverse Effects: What to Watch Out For84
Jacquelyn L. Bainbridge and Caleb Y. Oh

13 Antiepileptic Drug Interactions 91
Philip N. Patsalos

14 Recognizing Intractability to Antiepileptic Medication102
Bassel W. Abou-Khalil

15 Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy107
Nicholas P. Poolos

16 Rescue Medications for Home Treatment of Acute Seizures112
Peter Wolf and Rûta MameniSkienë

17 When and How to Stop Antiepileptic Drugs 118
John D. Hixson

18 Using Parenteral Antiepileptic Medications 122
Jane G. Boggs

19 Pharmacopeia 126
Gail D. Anderson

Part IV: Special Topics in Pediatric Epilepsy

20 Seizures in the Neonate 141
Adam L. Hartman and Frances J. Northington

21 Benign and Malignant Childhood Epilepsies 147
Katherine C. Nickels and Elaine C. Wirrell

22 Epilepsy: When to Perform a Genetic Analysis 159
Heather E. Olson and Annapurna Poduri

23 Metabolic Disorders Not to Miss 167
Phillip L. Pearl and Yuezhou Joe Yu

Part V: Special Topics in Adult Epilepsy

24 Juvenile Myoclonic Epilepsy and Other Primary GeneralizedEpilepsies 177
Shahin Hakimian

25 Epilepsy in Women of Childbearing Age 184
Autumn Klein

26 Epilepsy After Sixty 189
Edward Faught

Part VI: What can be done when medication doesn'twork?

27 When Should Epilepsy Neurosurgery Be Considered, and What CanIt Accomplish? 199
Paul A. Garcia

28 When Should Vagus Nerve Stimulation Be Considered, and WhatCan It Accomplish? 205
Pearce J. Korb and Sandra L. Helmers

29 Ketogenic Diet and Alternative Therapies 210
Dana Ekstein and Steven C. Schachter

Part VII: How are acute seizures and status epilepticusevaluated and treated in the emergency department and thehospital?

30 acute Symptomatic Seizures in Children and Adults: Evaluationand Treatment 217
J. Stephen Huff and Jessica L. Carpenter

31 Evaluating and Treating Status Epilepticus 222
Jeffrey Bolton and Howard P. Goodkin

32 Recognizing, Assessing, and Treating Seizures and StatusEpilepticus in the ICU 227
Nicolas Gaspard and Lawrence J. Hirsch

Part VIII: The morbidity and mortality of epilepsy

33 mortality in Epilepsy 243
Elizabeth J. Donner

34 Accidents in Epilepsy 248
Allan Krumholz and Ana M. Sanchez

35 Medical Comorbidity in Epilepsy 253
Kimberly L. Pargeon and Sheryl R. Haut

36 Cognitive Effects of Chronic Epilepsy 260
Daniel L. Drane

37 Recognizing and Treating Psychiatric Comorbidity in Epilepsy268
Jay Salpekar

Index 275

Color plate section between pages 80 and 8

Textauszug

Contributor List

Bassel W. Abou-Khalil, MD
Professor of Neurology
Director of the Epilepsy Center
Vanderbilt University School of Medicine
Nashville, TN, USA

 

Gail D. Anderson, PhD
Professor of Pharmacy, Pharmaceutics (adj) and Neurological Surgery (adj)
Department of Pharmacy
UW Regional Epilepsy Center
University of Washington
Seattle, WA, USA

 

Jacquelyn L. Bainbridge, PharmD, FCCP
Professor of Clinical Pharmacy and Neurology
University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences and School of Medicine
Anschutz Medical Campus
Aurora, CO, USA

 

Jane G. Boggs, MD
Associate Professor of Neurology
Wake Forest University School of Medicine
Comprehensive Epilepsy Center
Winston Salem, NC, USA

 

Jeffrey Bolton, MD
Staff Physician
Department of Neurology
Boston Children’s Hospital Division of Epilepsy
Instructor of Neurology
Harvard Medical School
Boston, MA, USA

 

Jessica L. Carpenter, MD
Assistant Professor
Department of Neurophysiology
Children’s National Medical Center
George Washington University
Washington, DC, USA

 

Mary B. Connolly, MB BCh
Division of Pediatric Neurology
Department of Pediatrics
British Columbia’s Children’s Hospital
Vancouver, British Columbia, Canada

 

Elizabeth J. Donner, MD, FRCPC
Associate Professor of Paediatrics
Division of Neurology
Department of Paediatrics
University of Toronto
The Hospital for Sick Children
Toronto, Ontario, Canada

 

Daniel L. Drane, PhD
Assistant Professor of Neurology and Pediatrics
Departments of Neurology and Pediatrics
Emory University School of Medicine
Atlanta, GA, USA
Department of Neurology
University of Washington School of Medicine
Seattle, WA, USA

 

Dana Ekstein, MD
Senior Neurologist
Department of Neurology
Epilepsy Center
Hadassah-Hebrew University Medical Center
Jerusalem, Israel

 

Edward Faught, MD
Professor of Neurology
Emory University
Atlanta, GA, USA

 

Paul A. Garcia, MD
Professor of Clinical Neurology
Director of Clinical Epilepsy Services
Department of Neurology
University of California San Francisco
San Francisco, CA, USA

 

Nicolas Gaspard, MD, PhD
Postdoctoral Research Associate
Division of Epilepsy and EEG
Neurology Department
Yale University School of Medicine
New Haven, CT, USA

 

Howard P. Goodkin, MD, PhD
The Shure Professor of Neurology and Pediatrics
Director, Division of Pediatric Neurology
Department of Neurology
University of Virginia
Charlottesville, VA, USA

 

Renzo Guerrini, MD
Professor and Director Neuroscience Department
Children’s Hospital A. Meyer
University of Florence
Florence, Italy

 

Shahin Hakimian, MD
Assistant Professsor of Neurology
Department of Neurology
UW Regional Epilepsy Center
University of Washington
Seattle, WA, USA

 

Adam L. Hartman, MD
Assistant Professor of Neurology, Pediatrics, and Molecular Microbiology and Immunology
Divisions of Epilepsy and Pediatric Neurology
Co-Director, Neurosciences Intensive Care Nursery
Johns Hopkins Medicine
Baltimore, MD, USA

 

Sheryl R. Haut, MD
Professor of Clinical Neurology
Director, Adult Epilepsy
Epilepsy Management Center, Einstein-Montefiore
Bronx, NY, USA
Department of Neurology, Montefiore Medical Center
Albert Einstein College of Medicine
Bronx, NY, USA

 

Sandra L. Helmers, MD, MPH
Professor of Neurology
Department of Neurology
Emory University School of Medicine
Atlanta, GA, USA

 

Lawrence J. Hirsch, MD
Professor of Neurology
Chief, Division of Epilepsy and EEG
Yale Comprehensive Epilepsy Center
Yale University School of Medicine
New Haven, CT, USA

 

John D. Hixson, MD
Department of Neurology
University of California San Francisco
San Francisco, CA, USA

 

Gregory L. Holmes, MD
Department of Neurological Sciences
University of Vermont
Burlington, VT, USA

 

J. Stephen Huff, MD
Professor of Emergency Medicine and Neurology
Departments of Emergency Medicine and Neurology
University of Virginia
Charlottesville, VA, USA

 

Autumn Klein, MD, PhD (Deceased)
Department of Neurology
UPMC Presbyterian/Magee Women’s Hospital of UPMC
Pittsburgh, PA, USA

 

Pearce J. Korb, MD
Instructor Department of Neurology
Emory University School of Medicine
Atlanta, GA, USA

 

Allan Krumholz, MD
Professor of Neurology
Department of Neurology
Director, Maryland Epilepsy Center
University of Maryland Medical Center
University of Maryland School of Medicine
Baltimore, MD, USA

 

Jennifer Langer, MD
Assistant Professor of Neurology
Department of Neurology
University of Virginia
Charlottesville, VA, USA

 

Rūta Mameniškienė, MD, PhD
Clinic of Neurology and Neurosurgery
Faculty of Medicine
Vilnius University
Vilnius, Lithuania
Epilepsy Centre
Department of Neurology
Vilnius University Hospital Santariškių Klinikos
Vilnius, Lithuania

 

John W. Miller, MD, PhD
Professor of Neurology and Neurological Surgery
Departments of Neurology and Neurological Surgery
University of Washington
Seattle, WA, USA
Director, UW Regional Epilepsy Center
Harborview Medical Center
Seattle, WA, USA

 

Valeria M. Muro, MD
Division of Pediatric Neurology
Department of Pediatrics
British Columbia’s Children’s Hospital
Vancouver, British Columbia, Canada

 

Aidan Neligan, MD
Clinical Research Fellow
Department of Clinical & Experimental Epilepsy
UCL Institute of Neurology
London, UK
Epilepsy Society
Chalfont St Peter, Buckinghamshire, UK

 

Katherine C. Nickels, MD
Assistant Professor of Child Neurology and Epilepsy
Mayo Clinic
Rochester, MN, USA

 

Frances J. Northington, MD
Professor of Pediatrics
Division of Neonatology
Director, Neurosciences Intensive Care Nursery
Neonatal Research Laboratory
Johns Hopkins Medicine
Baltimore, MD, USA

 

Edward J. Novotny, Jr., MD
Professor of Neurology, Pediatrics, Radiology and Neurosurgery
Director of Pediatric Epilepsy Program | Child Neurology
Alvord, Gerlich and Rhodes Family Endowed Chair in Pediatric Epilepsy
University of Washington
Seattle Children’s Hospital
Seattle, WA, USA

 

Caleb Y. Oh, PharmD
Clinical Research Fellow in Neurology
Department of Clinical Pharmacy
University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences
Anschutz Medical Campus
Aurora, CO, USA

 

Heather E. Olson, MD
Fellow in Epilepsy Genetics
Division of Epilepsy
Department of Neurology
Boston Children’s Hospital
Boston, MA, USA
Department of Neurology
Harvard Medical School
Boston, MA, USA

 

Kimberly L. Pargeon, MD
Epilepsy Management Center
Einstein-Montefiore
Bronx, NY, USA
Department of Neurology, Montefiore Medical Center
Albert Einstein College of Medicine
Bronx, NY, USA

 

Philip N. Patsalos, FRCPath, PhD
Professor of Clinical Pharmacology
Department of Clinical and Experimental Epilepsy
UCL-Institute of Neurology
London, UK
Epilepsy Society
Chalfont Centre for Epilepsy
Chalfont St Peter, Buckinghamshire, UK

 

Phillip L. Pearl, MD
Professor of Pediatrics, Neurology, and Music
The George Washington University School of Medicine and Columbian College of Arts and Sciences
Division Chief, Department of Child Neurology, Children’s National Medical Center
Washington, DC, USA

 

Vaishali S. Phatak, PhD
Assistant Professor of Neurology
UW Regional Epilepsy Center
University of Washington
Seattle, WA, USA

 

Annapurna Poduri, MD
Division of Epilepsy
Department of Neurology
Boston Children’s Hospital
Boston, MA, USA
Department of Neurology
Harvard Medical School
Boston, MA, USA

 

Nicholas P. Poolos, MD, PhD
Associate Professor of Neurology
Associate Director
Department of Neurology and UW Regional Epilepsy Center
University of Washington
Seattle, WA, USA

 

Mark Quigg, MD, MSc, FANA
Department of Neurology
University of Virginia
Charlottesville, VA, USA

 

Anna Rosati, MD, PhD
Pediatric Neurology Unit and Laboratories
Neuroscience Department
Children’s Hospital A. Meyer
University of Florence
Florence, Italy

 

Jay...

Produkt-Details

• Erscheint lt. Verlag: 6.1.2014
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Schlagworte: Accurate • Allgemeinpraxis, hausärztliche Praxis • Allgemeinpraxis, hausärztliche Praxis • Choices • Chronic Disease • Clinical • Common • Complex • Complicated • Condition • Epilepsie • Epilepsy • Evaluation • evaluation skills • Experience • General Practice/Family Practice • Intelligent • manifestations • many • Medical Science • Medizin • Neurological • Neurologie • Neurology • Range • requires • Treatment • Treatments • Variable
• ISBN-10: 1-118-45697-1 / 1118456971
• ISBN-13: 978-1-118-45697-2 / 9781118456972