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Hedgehog Signaling

From Origins to Therapies

P. Ingham (Autor)

Buch | Hardcover

400 Seiten

2016
John Wiley & Sons Inc (Verlag)
978-1-118-52483-1 (ISBN)

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Hedgehog Signaling: From Origins to Therapies is an in-depth survey of current understanding of Hedgehog signaling biology. Divided into three parts, the book covers mechanisms of action and evolution of the HH pathway; the biological functions of Hh, (principally in vertebrates); and clinical consequences of Hh dysfunction and the modulation of Hh signaling in regenerative medicine and cancer therapy.

Accessible to a wide readership, from advanced students to clinical practicioners, Hedgehog Signaling provides comprehensive coverage of how Hedeghog proteins are processed and secreted, how they are received and interpreted by cells, and the various ways in which they control the proliferation and differentiation of a diverse range of cell types. Designed as a reference for both researchers and clinicians interested in the pathological consequences of Hh dysfunction, as well as its potential for therapeutic applications, Hedgehog Signaling will also be a useful resource for all those interested in cell signalling in development, health and disease.

1. Introduction – a brief history of Hh

2. The Hh signaling pathway in Drosophila

3. The evolution of the Hh pathway

4. Production distribution and reception of the HH ligand

5. The Primary Cilium in HH signalling

6. Mechanisms of Hh signaling in mouse

7. Mechanisms of Hh signaling in zebrafish

8. Hh signaling in neural tube patterning in vertebrates

9. Hh signaling in limb development

10. Hh signaling in endodermal organs

11. Hh signaling in myogenesis

12. Hh signaling in skin biology

13. Hh signaling in bone biology

14. Hh signaling in blood and vascular biology

15. Physiological roles of HH

16. Hh signaling in regeneration

17. Hh and human congenital disorders

18. Hh in regenerative medicine

19. Hh in tumorigenesis 1

20. Hh in tumorigenesis 2

21. Hh in tumorigenesis 3

22. Hh therapeutics

Authors:

P Ingham (IMCB, Singapore)

M Scott (Stanford)

P Beachy (Stanford)

P Therond (CNRS, Nice)

A McMahon (Harvard/USC)

J Briscoe (Mill Hill)

M. Placzek (U Sheffield)

C. Tabin (Harvard Med School)

C. Tickle (U Bath)

D. Gummucio (U Michigan)

A–G Borycki (U Sheffield)

A Vortkamp (U Duisberg–Essen)

S Eaton (MPI Dresden)

K Anderson (MSK)

J Reiter (UCSF)

R Toftgard (Karolinska)

N Lawson (U Mass)

T Crompton (ICH, London)

P. Beales (ICH, London)

Y Sasai (Riken, Kobe)

T Curran (U Penn)

A Oro (Stanford)

F de Sauvage (Genentech, San Francisco)

Verlagsort	New York
Sprache	englisch
Maße	228 x 284 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-118-52483-7 / 1118524837
ISBN-13	978-1-118-52483-1 / 9781118524831
Zustand	Neuware