Antimalarial Chemotherapy

Mechanisms of Action, Resistance, and New Directions in Drug Discovery

Buch | Hardcover

396 Seiten

2001 | 2001 ed.
Humana Press Inc. (Verlag)
9780896036703 (ISBN)

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Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

I Introduction.- 1 The Need for New Approaches to Antimalarial Chemotherapy.- 2 The History of Antimalarial Drugs.- 3 Transport and Trafficking in Plasmodium-Infected Red Cells.- 4 The Plasmodium Food Vacuole.- 5 Clinical and Public Health Implications of Antimalarial Drug Resistance.- II Established Antimalarial Drugs and Compounds Under Clinical Development.- 6 Chloroquine and Other Quinoline Antimalarials.- 7 8-Aminoquinolines.- 8 Mechanisms of Quinoline Resistance.- 9 Folate Antagonists and Mechanisms of Resistance.- 10 Artemisinin and Its Derivatives.- 11 Atovaquone—Proguanil Combination.- 12 The Antimalarial Drug Portfolio and Research Pipeline.- III New Compounds, New Approaches, and New Targets.- 13 Novel Quinoline Antimalarials.- 14 New Antimalarial Trioxanes and Endoperoxides.- 15 Antibiotics and the Plasmodial Plastid Organelle.- 16 Fresh Paradigms for Curative Antimetabolites.- 17 Iron Chelators.- 18 Protease Inhibitors.- 19 Inhibitors of Phospholipid Metabolism.- 20 Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport.

Erscheint lt. Verlag	1.4.2001
Reihe/Serie	Infectious Disease
Zusatzinfo	XI, 396 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-13	9780896036703 / 9780896036703
Zustand	Neuware