NMDA Antagonists as Potential Analgesic Drugs

Dalip J.S. Sirinathsinghji, Ray G. Hill (Herausgeber)

Buch | Hardcover

VIII, 194 Seiten

2002
Springer Basel (Verlag)
978-3-7643-6011-5 (ISBN)

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There is now considerable preclinical evidence that glutamate acting via
the NMDA receptor is involved in the transmission of nociceptive
information and in the triggering mechanisms for hyperalgesia and
allodynia. This evidence allows rational development of a new class of
analgesic drugs that act as antagonists of the NMDA receptor, supported
by emerging evidence with existing excitatory amino acid antagonists.
L

There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. L

Pharmacology and electrophysiology of excitatory amino acid receptors.- Distribution of NMDA receptors in brain and spinal cord.- Spinal nociceptive processing: NMDA receptors and modulation by neuropeptides.- The NMDA receptor, pain and central sensitization.- Some pharmacological aspects of NMDA-mediated nociceptive transmission in the rat spinal cord as revealed by c-fos immunocytochemistry.- Interaction of NMDA and other neurotransmitter receptor systems in modulation of nociception.- Behavioural studies on the potential of NMDA receptor antagonists as analgesics.- Clinically available glutamate receptor antagonists in neuropathic pain states.- Future prospects for improved analgesic therapy.

Erscheint lt. Verlag	1.1.2002
Reihe/Serie	Progress in Inflammation Research
Zusatzinfo	VIII, 194 p.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	600 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Schlagworte	Analgesics • brain • Chemistry • Development • Drugs • Future • Molecular Biology • Neuropeptides • Pain • pharmacology • Physiology • Research • spinal cord • therapy • Treatment
ISBN-10	3-7643-6011-9 / 3764360119
ISBN-13	978-3-7643-6011-5 / 9783764360115
Zustand	Neuware