Immunotoxicology and Risk Assessment

Dennis K. Flaherty (Autor)

Buch | Softcover

382 Seiten

2013 | Softcover reprint of the original 1st ed. 2002
Springer-Verlag New York Inc.
978-1-4757-8188-5 (ISBN)

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This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US Food and Drug Administration, as well as data applicable to western European Nations.

to Immunotoxicology.- Innate Immunity.- Cells of the Immune System.- Immunogenicity and Antigenicity.- Antigen-Presenting Cells.- Antigen Presentation.- Surface Interactions and Intracellular Signaling.- B-Cell Activation.- Antibodies.- Immunological Memory.- Complement.- Phagocytosis and Intracellular Killing.- Immediate Hypersensitivity Reactions.- Autoimmunity.- Delayed Hypersensitivity Reactions.- Killer Cells.- Killer Cells and Viral Infections.- Transplantation.- The Kines.- Assessment of Biological Significance.- Risk Characterization.- References.

Zusatzinfo	X, 382 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
ISBN-10	1-4757-8188-1 / 1475781881
ISBN-13	978-1-4757-8188-5 / 9781475781885
Zustand	Neuware