Annual Review of Gerontology and Geriatrics, Volume 34, 2014

Genetics

Buch | Hardcover

224 Seiten

2014
Springer Publishing Co Inc (Verlag)
978-0-8261-9965-2 (ISBN)

Artikel merken

Enormous advances in our knowledge of genetic contributions to aging and disease, and in our understanding of the potential for manipulation of the aging process, have taken place during the past 20 years. This is the first volume in decades to consolidate this research in one place. It provides a broad and current overview of the most promising advances in genetic research on aging, current understanding of genetic contributions to the basic processes of aging, and age-related disease. The Review focuses on the aging process from lower organisms to man, and is organized in ascending order of biological complexity starting with stem cells and progressing through worms, flies, mice, and humans. Where relevant, the Review also includes information about yeasts and non-human primates.

The research presented in the Review uses a species-comparative approach that makes finding cross species similarities (gene conservation) and differences (gene differentiation) apparent. This approach reflects the way in which the field is organized, making it highly useful for investigators who want quick access and a concise summary of a particular topic.

Key Features:

Provides state-of-the-art information about promising advances in genetic research on aging
Comprises the first comprehensive volume regarding genetic research about aging in decades
Authored by leading scholars in the field
Disseminates enormous advances in our understanding of the aging process

Richard L. Sprott, PhD, is Executive Director of the Ellison Medical Foundation. Toni Antonucci, PhD, is Associate Dean for Academic Initiatives and Interdisciplinary Studies, Elizabeth M. Douvan Collegiate Professor of Psychology and Senior Research Scientist, Institute for Social Research Life Course Development Program, University of Michigan.

Preface

1. Longevity pathways in mammalian stem cells

Anne Brunet, Salah Mahmoudi, Elena Mancini, Victoria A. Rafalski, and Ashley E. Webb

2. Essential Genes and Lifespan

Sean P. Curran

3. Oxygen and Aging

Jason N. Pitt, Scott F. Leiser, and M. Kaeberlein

4. Aging, Disease and Longevity in Mice

David B. Lombard and Richard A. Miller

5. Primate Models for Human Brain Aging and Neurological Diseases

Caleb Finch and Steve Austad

6. Genes for Exceptional Longevity

Nir Barzilai and Gil Atzmon

7. Etiology of Individual Differences in Human Health and Longevity

Deborah Finkel, Lotte Gerritsen, Chandra A. Reynolds, Anna K. Dahl, and Nancy L. Pedersen

8 Exploiting causal complexity in aging

Gerald E. McClearn, David J. Vandenbergh, J. Tobias Stout, and Roger J. McCarter

9. Networks in the Biology of Aging: Powerful tools for a complex process

Mark A. McCormick and Daniel E. L. Promislow

10. Nature, Nurture & Chance: Their Roles in Interspecific & Intraspecific Modulations of Aging

George M. Martin

Mitarbeit	Herausgeber (Serie): Toni C. Antonucci
Zusatzinfo	10 Illustrations; 10 Illustrations
Verlagsort	New York
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
	Medizin / Pharmazie ► Pflege ► Altenpflege
	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
	Sozialwissenschaften ► Soziologie
ISBN-10	0-8261-9965-8 / 0826199658
ISBN-13	978-0-8261-9965-2 / 9780826199652
Zustand	Neuware