Evidence-Based Pediatric Oncology (eBook)

Ross Pinkerton, A. G. Shankar, Katherine Matthay (Herausgeber)

eBook Download: PDF

2013 | 3. Auflage
John Wiley & Sons (Verlag)
978-1-118-62532-3 (ISBN)

Infos

The new and updated edition of the renowned reference for pediatric oncologists

This groundbreaking text on the management of childhood cancers covers most tumor types occurring in children and young adults and provides reviews of randomized trials with commentaries on the optimum treatments for childhood cancer.

Updated with evidence from the latest published reviews-and even more clinically focused than previous editions- Evidence-Based Pediatric Oncology, Third Edition places an emphasis on application of the trial findings. With increased coverage of the area of supportive care for pediatric cancer patients, each chapter opens with an expert commentary on the key clinical issues followed by a summary of trial findings.

Evidence-Based Pediatric Oncology, Third Edition:

• Presents evidence for the best treatment of children and adolescents with cancer

• Includes commentaries from the world's leading experts for every topic discussed

• Is internationally relevant thanks to contributions from the UK, US, Canada and Australia

• Places greater emphasis on supportive care and features a new extended section on antibiotic and antifungal treatments

Based on information gathered from randomized trials performed after the release of the Second Edition, readers will find Evidence-Based Pediatric Oncology to be an important resource for all those treating young people with cancer.

Edited by
Ross Pinkerton, MB, BCh, BaO, MD, Executive Director, Division of Oncology, Royal Children's Hospital, Children's Health Queensland, Brisbane, QLD, Australia

Ananth Shankar, MD, FRCPCH, Consultant in Paediatric and Adolescent Oncology, University College
London Hospitals NHS Foundation Trust, London, UK

Katherine K. Matthay, BA, MD, Mildred V. Strouss Professor of Translational Oncology, Director, Pediatric Hematology-Oncology, Department of Pediatrics, UCSF School of Medicine and UCSF Benioff Children's Hospital, San Francisco, CA, USA

Inhalt

Evidence-Based Pediatric Oncology 5
Copyright 6
Contents 7
List of contributors 9
Preface 11
List of abbreviations 12
About the companion website 17
Part 1: Solid tumors 19
Chapter 1 Rhabdomyosarcoma 21
Commentary by Meriel Jenney 21
Philosophy of treatment of rhabdomyosarcoma 21
Treatment: the general approach 21
Lessons from studies of rhabdomyosarcoma 22
Lessons from studies of nonrhabdomyosarcoma soft tissue sarcomas 24
Conclusion 24
References 25
Summary of previous studies 26
References 28
New studies 29
Study 1 29
Study 2 30
Chapter 2 Osteosarcoma 32
Commentary by Maria Michelagnoli 32
References 35
Summary of previous studies 36
References 38
New studies 40
Study 1 40
Study 2 41
Study 3 42
Chapter 3 Ewing sarcoma 43
Commentary by Steven G. DuBois 43
References 44
Summary of previous studies 45
References 46
New studies 47
Study 1 47
Study 2 47
Study 3 48
Study 4 49
Study 5 49
Study 6 50
Study 7 50
Chapter 4 Wilms tumor 52
Commentary by Kathy Pritchard-Jones 52
References 54
Summary of previous studies 56
References 59
New studies 61
Study 1 61
Study 2 62
Study 3 63
Chapter 5 Neuroblastoma 65
Commentary by Katherine K. Matthay 65
References 66
Summary of previous studies 68
References 69
New studies 71
Study 1 71
Study 2 71
Study 3 72
Study 4 73
Study 5 74
Study 6 75
Chapter 6 Hepatoblastoma 76
Commentary by Penelope Brock 76
References 78
Summary of previous studies 79
References 79
New studies 80
Study 1 80
Study 2 81
Chapter 7 Malignant germ cell tumors 83
Commentary by Ross Pinkerton 83
References 84
Summary of previous studies 85
References 85
New studies 86
Chapter 8 Medulloblastoma 87
Commentary by Eric Bouffet 87
Early randomized studies 88
Recent medulloblastoma trials 89
Future directions 90
References 90
Summary of previous studies 92
References 94
New studies 96
Study 1 96
Study 2 96
Study 3 97
Chapter 9 Glioma 99
Commentary by Joann L. Ater 99
Radiation therapy 100
Chemotherapy 100
Conclusions 101
References 101
Summary of previous studies 103
References 104
New studies 105
Chapter 10 Non-Hodgkin lymphoma 106
Commentary by Ross Pinkerton 106
References 110
Summary of previous studies 112
References 114
New studies 115
Study 1 115
Study 2 117
Study 3 118
Study 4 120
Chapter 11 Hodgkin lymphoma 123
Commentary by Cindy L. Schwartz 123
Radiation therapy 123
Combination therapy 124
Chemotherapy only 124
References 126
Summary of previous studies 127
References 130
New studies 131
Study 1 131
Study 2 132
Part 2: Leukemia 135
Section 1: Acute myeloid leukemia 137
Chapter 12 Acute myeloid leukemia commentary 137
Induction 137
Postremission therapy 139
References 141
Chapter 13 Remission induction in acute myeloid leukemia 144
Summary of previous studies 144
References 146
New studies 147
Study 1 147
Study 2 148
Study 3 149
Study 4 150
Chapter 14 Acute myeloid leukemia consolidation 153
New study 153
Study 1 153
Chapter 15 Maintenance treatment in acute myeloid leukemia 155
Summary of previous studies 155
References 157
New studies 158
Chapter 16 Autologous bone marrow transplantation in acute myeloid leukemia 159
Summary of previous studies 159
References 160
New studies 161
Chapter 17 Acute myeloid leukemia: miscellaneous 162
New study 162
Study 1 162
Section 2: Childhood lymphoblastic leukemia 164
Chapter 18 Childhood lymphoblastic leukemia commentary 164
Remission induction 164
Postinduction therapy 166
Continuation therapy 167
Minimal residual disease 167
Relapsed acute lymphoblastic leukemia 168
Long-term effects 168
New agents 168
References 169
Chapter 19 Remission induction in childhood lymphoblastic leukemia 172
Summary of previous studies 172
References 175
New studies 177
Study 1 177
Study 2 178
Study 3 179
Study 4 180
Study 5 182
Study 6 183
Study 7 184
Chapter 20 Central nervous system-directed therapy in childhood lymphoblastic leukemia 186
Summary of previous studies 186
Dose of irradiation 186
The need for irradiation in central nervous system-directed therapy 187
Schedule of irradiation 190
Type of intrathecal therapy and duration of treatment 191
Role of intermediate- and high-dose methotrexate 192
Role of high-dose cytarabine 193
Overview 194
References 195
New studies 197
Chapter 21 Maintenance treatment in childhood lymphoblastic leukemia 198
Summary of previous studies 198
Duration of therapy 198
Pulses of steroids and vincristine 199
Dose and route of methotrexate 200
Drug schedule 200
Type of thiopurine 201
Addition of other drugs during continuing therapy 202
References 202
New studies 204
Pulses of vincristine and steroids 204
Study 1 204
Study 2 205
Drug schedule 207
Study 3 207
Study 4 208
Study 5 208
Type of thiopurine 210
Study 6 210
Study 7 211
Study 8 213
Addition of other drugs during continuing therapy: role of intermediate-/high-dose cytarabine 215
Study 9 215
Chapter 22 Relapsed childhood lymphoblastic leukemia 216
New studies 216
Study 1 216
Study 2 217
Study 3 219
Study 4 220
Chapter 23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia 222
New studies 222
Study 1 222
Study 2 223
Part 3: Supportive care in pediatric oncology 225
Chapter 24 Colony-stimulating factors 227
Commentary by Victoria Grandage 227
References 229
Summary of previous studies 231
Granulocyte colony-stimulating factor 231
References 236
Granulocyte macrophage colony-stimulating factor 237
References 238
Erythropoietin 238
References 240
New studies 241
Study 1 241
Study 2 241
Study 3 242
Study 4 244
Study 5 245
Study 6 246
Chapter 25 Cardioprotection in pediatric oncology 248
Commentary by Gill A. Levitt 248
References 249
Summary of previous studies 251
References 252
New studies 253
Adverse effects of cardioprotectant (dexrazoxane) 253
Study 1 253
Study 2 253
Study 3 254
Efficacy of anthracyclines in pediatric oncology 256
Study 4 256
Study 5 257
Chapter 26 Infections in pediatric and adolescent oncology 261
Commentary by Julia E. Clark 261
Introduction 261
Risk stratification 262
Fungal infection 262
Central venous catheter infections 264
New studies 265
Fungal infections 265
Study 1 265
Study 2 266
Study 3 267
Study 4 268
Study 5 270
Bacterial infections 271
Study 6 271
Study 7 272
Study 8 273
Study 9 274
Study 10 275
Study 11 276
Study 12 277
Study 13 278
Study 14 279
Study 15 280
Study 16 280
Study 17 281
Line infections 281
Study 18 281
Study 19 282
Study 20 283
Index 287

Produkt-Details

• Erscheint lt. Verlag: 19.2.2013
• Reihe/Serie: Evidence-Based Medicine
• Reihe/Serie: Evidence-Based Medicine
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie
• Schlagworte: application • Childhood • clinically • Edition • Editions • Evidence • Evidence-based Health Care • evidencebased pediatric • Evidenzbasierte Forschung im Gesundheitswesen • Evidenzbasierte Medizin • Focused • groundbreaking • Latest • Management • Medical Science • Medizin • New • oncologists • Oncology • Pädiatrische Onkologie • Pädiatrische Onkologie • Pediatric • Places • previous • published • Reference • renowned • reviewsand • Trial
• ISBN-10: 1-118-62532-3 / 1118625323
• ISBN-13: 978-1-118-62532-3 / 9781118625323