Drug Discovery from Nature

Buch | Softcover

XIX, 347 Seiten

2000 | Softcover reprint of the original 1st ed. 2000
Springer Berlin (Verlag)
978-3-540-66947-0 (ISBN)

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Drug discovery strategies for both pharmaceutical and agrochemical applications are at a stage of rapid development. More than 30 % of sales of drugs for human consumption worldwide are of plant origin. This unique book covers the present status and future potential of natural products in drug discovery. It provides the reader with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods. Because the renewed interest in the use of natural sources in drug discovery is an important supplement to combinatorial and parallel synthesis approaches, this book is timely and will have a great scientific impact.

The Impact of Natural Products on Drug Discovery.- Recent Developments in Drug DiscoveryTechnologies.- Technical Aspects.- A Central Natural Product Pool- New Approach in Drug Discovery Strategies.- Automation Strategies in Drug Discovery.- Synergistic Use of Combinatorial and Natural Product Chemistry.- Supercritical Fluid Extraction (SFE) - Novel Strategies in the Processing of Biomaterials.- Natural Products from Microbial Sources.- Secondary Metabolites: From Past to Present.- The Chemical Screening Approach.- Myxobaderia as Producers of Secondary Metabolites.- Trends in Marine Biotechnology.- Biochemistry and Molecular Biology Based Methods.- Structure Modification via Biological Derivatization Methods.- Molecular Biological Aspects of Antibiotic Biosynthesis.- Combinatorial Biosynthesis of Antibiotics.- Aspects in Application.- Impact of Natural Products on Cell Biology: Low-Molecular Mass Effectors of Folding Helper Proteins.- Novel Antibacterial Drugs from Microorganisms.- New Antibiotics with Novel Mode of Action.- Synthetic Combinatorial Libraries: A New Tool for Antimicrobial Agent Discovery.- Strobilurins and Oudemansins.

Erscheint lt. Verlag	14.2.2000
Reihe/Serie	Springer Desktop Editions in Chemistry
Zusatzinfo	XIX, 347 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	484 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	Discovery • Drug • Nature • Naturheilkunde • Naturheilkunde / Naturmedizin • Pharmakologie
ISBN-10	3-540-66947-7 / 3540669477
ISBN-13	978-3-540-66947-0 / 9783540669470
Zustand	Neuware