Immunotherapy in Transplantation (eBook)

Principles and Practice

Bruce Kaplan, Gilbert J. Burkhart, Fadi G. Lakkis (Herausgeber)

eBook Download: EPUB

2012 | 1. Auflage
600 Seiten
John Wiley & Sons (Verlag)
978-1-4443-5560-4 (ISBN)

Infos

This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.

Autor

Bruce Kaplan, MD, Professor of Medicine, Surgery and Pharmacology, Co-Director UIC Transplant Center, University of Illinois at Chicago, USA and Adjunct Professor of Medicine, Applied Genomics Center, University of Alberta, Canada. Gilbert Burkhart, Pharm D, Department of Medicine, University of Southern California (USC), San Francisco, USA. Phil Halloran, MD, PhD, Professor of Medicine, Director of Nephrology and Immunology, University of Alberta, Edmonton, Canada.

Inhalt

List of Contributors.

Preface.

Section 1: Transplantation Immunobiology.

1 The Immune Response to a Transplanted Organ: An Overview
(Fadi G. Lakkis).

2 Antigen Presentation in Transplantation (Martin H.
Oberbarnscheidt and Fadi G. Lakkis).

3 The T Cell Response to Transplantation Antigens (Didier A.
Mandelbrot, Bryna Burrell, Mohamed H. Sayegh and Peter S.
Heeger).

4 The B Cell Response to Transplantation Antigens (Roger
Sciammas, Anita S. Chong, Robert B. Colvin).

5 The Innate Response to a Transplanted Organ (Daniel
R. Goldstein and Laurence A. Turka).

6 Regulation of the Alloimmune Response (Kathryn J Wood and
Terry B Strom).

Section 2: Transplantation Clinical Pharmacology.

7 Pharmacokinetics (Raman Venkataramanan).

8 Therapeutic Drug Monitoring for Immunosuppressive Agents
(Michael C. Milone and Leslie M. J. Shaw).

9 Pharmacometrics: Concepts and Applications to Drug Development
(Mallika Lala and Jogarao V. S. Gobburu).

10 Pharmacogenomics and Organ Transplantation (Gilbert J.
Burckart and Richard M. Watanabe).

11 Study Design/process of development: Clinical studies
(Richard D. Mamelok).

Section 3: Agents.

12 Corticosteroids (Olivia Blume, Sarah E. Yost and Bruce
Kaplan).

13 Azathioprine (Barry J. Browne).

14 Pharmacokinetic and Pharmacodynamic Properties of
Mycophenolate (David Hager, Arjang Djamali, Bruce
Kaplan).

15 Cyclosporine: Molecular Action to Clinical Therapeutics
(Bradford Strijack and Paul A. Keown).

16 Tacrolimus (William E. Fitzsimmons).

17 Inhibitors of Mammalian Target of Rapamycin (Barry D.
Kahan).

18 Inhibitors Targeting JAK3 (Gary Chan, Paul S.
Changelian).

19 Cyclophosphamide (John J. Curtis).

20 Application of antisense technology in medicine (Stanislaw
M. Stepkowski, Beata Mierzejewska, Frank C. Bennett).

21 The role of ganciclovir in transplantation (Lyndsey J.
Bowman and Daniel C. Brennan).

22 Transplantation Immunotherapy with Anti-Thymocyte Globulin
(ATG) (John L. Dzuris, Christian Bloy, Melanie Ruzek, John M.
Williams).

23 The Role of Alemtuzumab in Solid Organ Transplantation
(Avinash Agarwal, David Bruno and Stuart J.
Knechtle).

24 Rituximab, an anti-CD20 monoclonal antibody (Mark D.
Pescovitz).

25 The Anti-Interleukin 2 Receptor Antibodies (Muna Alnimri
and Flavio Vincenti).

26 Infliximab/ Anti-TNF (Marina Vardanyan, Edward C. Parkin,
Horacio L. Rodriguez Rilo).

27 CTLA4-Ig (Sarah E. Yost and Bruce Kaplan).

28 Combination and Adjuvant Therapies to Facilitate the Efficacy
of Costimulatory Blockade (Swetha K. Srinivasan, Helen L.
Triemer, Allan D. Kirk).

29 Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and
Inflammation with Applications in Solid Organ Transplantation
(Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng and
Ashley A. Vo).

Index.

Rezensionen

"Overall, the text is highly structured, well presented
and applicable to transplant clinicians and pharmacologists in
particular. . . . Those wishing to advance their understanding of
transplant immunology, the technologies and techniques used for
drug monitoring, the drug development pipeline and the basis for
use of current agents in transplantation will find their interests
more than satisfied." (American Journal of
Transplantation, 5 September 2013)

"It will serve a clinician well as a focused reference for
immunology and pharmacotherapy relevant to the transplant arena. It
would be a welcome and useful addition to the medical or
pharmaceutical library of a transplant professional or institution,
albeit on the expensive side for a focused textbook."
(The Annals of Pharmacotherapy, 1 March 2013)

"This comprehensive reference source will benefit all
transplant specialists working with pharmacologic and biologic
agents that modulate the immune system." (European
Journal of Immunology, 1 December 2012)

"This is a decent review of transplant immunology that is
helpful for the training practitioner. Given its systematic
approach, it is easier to follow than other books on the
subject." (Doody's, 17 August 2012)

Produkt-Details

• Erscheint lt. Verlag: 23.2.2012
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
• Schlagworte: Brustchirurgie • Medical Science • Medizin • Transplantation • Transplantationen
• ISBN-10: 1-4443-5560-0 / 1444355600
• ISBN-13: 978-1-4443-5560-4 / 9781444355604