Oral Bioavailability (eBook)

Basic Principles, Advanced Concepts, and Applications

Ming Hu (Herausgeber)

Xiaoling Li (Autor)

eBook Download: EPUB

2011 | 1. Auflage
560 Seiten
John Wiley & Sons (Verlag)
978-1-118-06758-1 (ISBN)

Infos

Understand and assess the design, delivery, and efficacy of
orally administered drugs

A practical guide to understanding oral bioavailability, one of
the major hurdles in drug development and delivery, Oral
Bioavailability: Basic Principles, Advanced Concepts, and
Applications is designed to help chemists, biologists, life science
researchers, pharmaceutical scientists, pharmacologists,
clinicians, and graduate and students become familiar with the
fundamentals and practices of the science of oral
bioavailability.

The difference in rate and extent between a drug taken orally
and the actual amount of a drug reaching the circulatory system,
oral bioavailability is an essential parameter for determining the
efficacy and adverse effects of new and developing medications, as
well as finding an optimal dosing regimen.

This book provides a much-needed one-stop resource to help
readers better understand and appreciate the many facets and
complex problems of oral bioavailability, including the basic
barriers to oral bioavailability, the methods used to determine
relevant parameters, and the challenges of drug delivery.

In addition, this comprehensive book discusses biological and
physicochemical methods for improving bioavailability, integrates
physicochemistry with physiology and molecular biology, and
includes several state-of-the-art technologies and
approaches--Caco-2 cell culture model, MDCK, and other related
cell culture models--which are used to study the science of
oral bioavailability.

Autor

Ming Hu, PhD, is Professor of Pharmaceutics at the College of Pharmacy, University of Houston. Dr. Hu is on the editorial boards of Molecular Pharmaceutics and the Journal of Alternative and Complementary Medicine. Xiaoling Li, PhD, is Professor of Pharmaceutics and Associate Dean of Graduate Education and Research at the Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific. He is a Fellow of the American Association of Pharmaceutical Scientists.

Rezensionen

"This book comprehensively covers the topics and issues of oral bioavailability and applications in drug development. The book helps readers master the basic terminology of the field, understand the basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend the challenge associated with oral drug delivery." (Fort Mill Times, 18 October 2011)

Produkt-Details

• Erscheint lt. Verlag: 4.8.2011
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley series in drug discovery and development
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Bioverfügbarkeit • Bioverfügbarkeit • Chemie • Chemische Biologie • Chemistry • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-06758-4 / 1118067584
• ISBN-13: 978-1-118-06758-1 / 9781118067581