Kinase Inhibitor Drugs (eBook)

Rongshi Li, Jeffrey A. Stafford (Herausgeber)

eBook Download: PDF

2009
John Wiley & Sons (Verlag)
978-0-470-52495-4 (ISBN)

Infos

A comprehensive resource on case studies of marketed kinase drugs and promising drug trials Since the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development. In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. Kinase Inhibitor Drugs includes: Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discovery Current thinking on kinase structure, biochemistry, and signal transduction pathways Information on state-of-the-art technologies and tools such as structure-based and fragment-based drug discovery A lineup of clinical-phase growth factor receptor inhibitors Inhibitors of cell cycle kinases The discovery of allosteric inhibitors of MEK kinase Information on pharmacogenomics and its application to kinase inhibitor clinical development

Autor

Rongshi Li, PhD, is an Associate Professor in the Drug Discovery Department at H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. Jeffrey A. Stafford, PhD, has led drug discovery research at GlaxoSmithKline, Syrrx, and Takeda. He is a co-inventor of the tyrosine kinase inhibitor, pazopanib (Armala).

Inhalt

PREFACE.

CONTRIBUTORS.

PART I GROWTH FACTOR INHIBITORS: VEGFR2, ERBB2, AND OTHER
KINASE.

1 Discovery and Development of Sunitinib (SU11248): A
Multitarget Tyrosine Kinase Inhibitor of Tumor Growth, Survival,
and Angiogenesis (Connie L. Sun, James G. Christensen, and
Gerald McMahon).

2 Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase
Inhibitor (Karen Lackey and G. Stuart Cockerill).

3 Discovery of Pazopanib: A Pan Vascular Endothelial Growth
Factor Kinase Inhibitor (Philip A. Harris and Jeffrey A.
Stafford).

4 Road to ABT-869: A Multitargeted Receptor Tyrosine Kinase
Inhibitor (Michael Michaelides and Daniel H. Albert).

5 Discovery of Motesanib (Andrew S. Tasker and Vinod F.
Patel).

6 Discovery of Brivanib Alaninate: A Dual Vascular Endothelial
Growth Factor and Fibroblast Growth Factor Receptor Inhibitor
(Rajeev S. Bhide and Joseph Fargnoli).

7 S tructure-Based Design and Characterization of Axitinib
(Robert S. Kania).

PART II GROWTH FACTOR INHIBITORS: MEK INHIBITORS.

8 Road to PD0325901 and Beyond: The MEK Inhibitor
Quest (Judith S. Sebolt-Leopold and Alexander J.
Bridges).

9 Discovery of Allosteric MEK Inhibitors (Eli Wallace
and James F. Blake).

PART III CELL CYCLE KINASE INHIBITORS: AURORA KINASE AND PLK
INHIBITORS.

10 Discovery of MK-0457 (VX-680) (Julian M. C.
Golec).

11 Discovery of PHA-739358 (Daniele Fancelli and Jürgen
Moll).

12 Discovery of AZD1152: A Selective Inhibitor of Aurora-B
Kinase with Potent Antitumor Activity (Kevin M. Foote and Andrew
A. Mortlock).

13 Case Study of Aurora-A Inhibitor MLN8054 (Christopher F.
Claiborne and Mark G. Manfredi).

14 Discovery of GSK461364: A Polo-like Kinase 1 Inhibitor for
the Treatment of Cancer (Kevin W. Kuntz and Kyle A.
Emmitte).

PART IV RELATED SPECIAL TOPICS.

15 Pharmacogenomics of Dasatinib (Sprycel) (Fei Huang and
Edwin A. Clark).

16 Practical Use of Computational Chemistry in Kinase Drug
Discovery (James M. Veal).

17 Approaches to Kinase Homology Modeling: Successes and
Considerations for the Structural Kinome (Victoria A. Feher and
J. David Lawson).

18 Fragment-Based Drug Discovery of Kinase Inhibitors (Daniel
A. Erlanson).

19 Protein Kinase Structural Biology: Methods and Strategies for
Targeted Drug Discovery (Clifford D. Mol, Kengo Okada, and David
J. Hosfield).

INDEX.

Rezensionen

"In conclusion, I strongly recommend this book to anyone who is
interested and new to the field of kinase inhibitors. Indeed, I
believe this book should not merely sit on the shelves of kinase
experts, but should be used frequently for reference."
(ChemMedChem, 2010)

"Delivers what the title promises: a comprehensive treatment of
drugs that inhibit kinases. ... Will be interesting to any chemist
or biologist desiring a behind-the-scenes look at modern strategies
of drug discovery and their practical applications to some
challenging targets." (Journal of Medicinal Chemistry, April
2010)

Produkt-Details

• Erscheint lt. Verlag: 4.11.2009
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley Series in Drug Discovery and Development
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Activity • bcrabl kinase • Biowissenschaften • CASE • Cell & Molecular Biology • Chemie • Chemistry • Chronic • Clinical • compelling • Comprehensive • Discovery • Drug • Drug Discovery & Development • Field • Gleevec • highly • Inhibitor • Kinase • kinase drugs • leukemia • Life Sciences • Medical Science • Medizin • Molekularbiologie • myelogenous • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Protein • Researchers • resource • Studies • Treatment • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung • Zell- u. Molekularbiologie
• ISBN-10: 0-470-52495-2 / 0470524952
• ISBN-13: 978-0-470-52495-4 / 9780470524954